Film Materials With Tiamulin Fumarate on the Basis of Polyurethaneureas, Which Containing in the Structure Fragments of a Copolymer of N-Vinylpyrrolidone With Vinyl Alcohol

Rudenchyk, T. V.; Roznova, R.A.; Galatenko, N.A.; Kiselova, T.O.

doi:10.18524/2304-0947.2016.3(59).79591

Odesa National University Herald. Chemistry

2016

DOI: 10.18524/2304-0947.2016.3(59).79591

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Film Materials With Tiamulin Fumarate on the Basis of Polyurethaneureas, Which Containing in the Structure Fragments of a Copolymer of N-Vinylpyrrolidone With Vinyl Alcohol

T. V. Rudenchyk

R.A. Roznova

N.A. Galatenko

et al.

Abstract: Синтезовано ряд гідрофільних плівкових матеріалів з тіамулін фумаратом на основі поліуретансечовин (ПУС), які містять у своїй структурі фрагменти кополімеру N-вінілпіролідону з вініловим спиртом за різного співвідношення компонентів. Методом ІЧ-спектроскопії досліджено структуру отриманих полімерних матеріалів та встановлено, що іммобілізація тіамулін фумарату відбувається за рахунок фізичних зв'язків. Введеня до складу ПУС тіамулін фумарату приводить до підвищення фізико-механічних властивостей, які знаходять… Show more

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Composite materials based on polyurethane with fragments of poly(vinyl butyral-vinyl acetate-vinyl alcohol) copolymer in their structure filled with silver- and copper-containing silica

Vislohuzova¹,

Galatenko²,

Rozhnova³

et al. 2022

Him. Fiz. Tehnol. Poverhni

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A series of polymeric composites based on polyurethanes with copolymer fragments of poly(vinyl butyral-vinyl acetate-vinyl alcohol) and 1,6-hexamethylenediamine filled with modified precipitated silica were synthesized. The content of silver in the nanocomposites was 0.1–0.2 and of copper – 0.14 and 0.2 mmol per 1 g of SiO2 (02AgCu; AgCu and 01Ag samples). The content of silver-containing silica filler in the polymer composites was 0.1, 0.5 and 1.0 wt. %. By means of the IR spectroscopy, it has been found that a physical immobilization of modified silica in the polymeric matrix takes place due to the presence of intermolecular hydrogen bonds. The influence of fillers on the structure and properties of polymer materials, in particular, on thermophysical properties and physico-mechanical parameters (tensile strength and relative elongation at rupture), were investigated. The results of physico-mechanical tests indicate that the strength characteristics of polyurethane depend on the content and concentration of fillers. It has been found that the polymeric sample filled with 02AgCu nanocomposite (0.2 mmol of Ag and Cu per 1 g of SiO2) has the highest strength of the rupture. It has been shown that the introduction of modified silica leads to a reduction of relative elongation at rupture of polymeric nanocomposite. The highest values showed the sample filled with AgCu (0.1 and 0.12 mmol Ag and Cu, respectively, per 1 g of SiO2). The introduction of silver-containing silica nanocomposites into a polyurethane, containing polyvinylbutiral copolymer fragments, leads to an increase in tensile strength and reduction of relative elongation at rupture. Polymeric composite with 0.5 wt. % of filler had the highest values of physico-mechanical parameters. It has been shown that the thermosphysical characteristics depend on the concentration and composition of the fillers and have a nonlinear character. The synthesized nanocomposites can be effectively used as biomedical materials.

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Composite materials based on polyurethane with fragments of poly(vinyl butyral-vinyl acetate-vinyl alcohol) copolymer in their structure filled with silver- and copper-containing silica

Vislohuzova¹,

Galatenko²,

Rozhnova³

et al. 2022

Him. Fiz. Tehnol. Poverhni

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Development and Research of Composite Materials With Dacarbazine Based on Polyurethane-Urea With Fragments of Polyvinyl Alcohol-Polyethylene Glycol Graft Copolymer in the Structure

VISLOHUZOVA,

ROZHNOVA,

KISELOVA

et al. 2024

Polim. z.

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Based on diisocyanate prepolymer (DPP), the series of polyurethane-urea (PUU) with fragments of polyvinyl alcohol-polyethylene glycol (PVA-PEG) graft copolymer and 4,4’-diaminodiphenylmethane (DADPh) macrochain extender in the structure at different molar ratios of DPP:DADPh:PVA-PEG (1.0:0.7:0.3; 1.0:0.8:0.2; 1.0:0.9:0.1) were synthesized. Composite materials with the drug dacarbazine (DAС) in the amount of 1.0 wt.% based on the obtained PUU were developed. Studies of the structure and properties of PUU and composite materials with DAC based on them were carried out. The immobilization of DAC was found to be due to intermolecular hydrogen bonds by means of IR spectroscopy. According to the results of physical-mechanical tests, the introduction of DAC into the composition of PUU causes a non-significant decrease in the physical-mechanical properties, which is probably associated with a decrease in the packing density of macrochains of the polymer matrix. According to DSC, the studied systems are single-phase with a glass transition temperature (Tg) ranging from -12.50 to -31.99 °C. The introduction of DAC into the composition of PUU causes an increase in Tg and the specific heat capacity at the values of the glass transition temperature, which can be caused by a change in chain mobility due to the introduction of the filler and is correlated with the data of physical-mechanical tests. According to the results of hydrophilicity studies the introduction of PVA-PEG graft-copolymer into the PUU structure and increasing its content leads to an increase in hydrophilicity, which will contribute to a prolonged release of DAC from the polymer matrix. Therefore, the obtained composites with DAC are promising materials that can be used in medical practice as biologically active polymeric materials with a prolonged effect of an anticancer drug.

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Study of Biodegradation, Biocompatibility and Bactericidal Activity of Film Materials with Tiamulin Fumarate Based on Polyurethaneurea

Rudenchyk¹,

Rozhnova²,

Galatenko³

et al. 2020

ChChT

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The influence of the model biological medium 199 on the structure and properties of film materials with tiamulin fumarate based on polyurethaneurea containing in its structure the hydrophilic fragments of the copolymer of N-vinylpyrrolidone with vinyl acetate and vinyl alcohol has been investigated. According to IR spectroscopy, under the influence of the biological medium 199 there are processes of biodegradation of polymer materials which are accompanied by a decrease in the intensity of the absorption band ν С=О of vinylpyrrolidone ring. It is established that the introduction of tiamulin fumarate into polyurethaneurea facilitates their biodegradation, as evidenced by a decrease of the tensile strength (1.28-2.38 times) and a relative elongation at break (1.36-1.82 times) after incubation in the biological medium 199 by physicomechanical tests. The tissue culture method has established the biocompatibility of film materials with tiamulin fumarate. According to the results of microbiological studies, bactericidal properties were observed in relation to the bacteria Staphylococcus aureus and Escherichia coli. It allows using them for production of drainage in abdominal surgery.

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Film Materials With Tiamulin Fumarate on the Basis of Polyurethaneureas, Which Containing in the Structure Fragments of a Copolymer of N-Vinylpyrrolidone With Vinyl Alcohol

Cited by 4 publications

References 0 publications

Composite materials based on polyurethane with fragments of poly(vinyl butyral-vinyl acetate-vinyl alcohol) copolymer in their structure filled with silver- and copper-containing silica

Composite materials based on polyurethane with fragments of poly(vinyl butyral-vinyl acetate-vinyl alcohol) copolymer in their structure filled with silver- and copper-containing silica

Development and Research of Composite Materials With Dacarbazine Based on Polyurethane-Urea With Fragments of Polyvinyl Alcohol-Polyethylene Glycol Graft Copolymer in the Structure

Study of Biodegradation, Biocompatibility and Bactericidal Activity of Film Materials with Tiamulin Fumarate Based on Polyurethaneurea

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