Filogenia de vírus da raiva isolados de morcegos frugívoros do gênero Artibeus e  relacionados a morcegos hematófagos com base nos genes codificadores da nucleoproteína N e glicoproteína G

Fahl, Willian de Oliveira

doi:10.11606/d.10.2009.tde-18022010-092648

Cited by 3 publications

(4 citation statements)

References 26 publications

(34 reference statements)

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“…The presence of variant 3, revealed by viral typification of the isolates in all species of Artibeus, is in agreement with other studies, indicating a strong relationship of this variant with bats from this genus 21,22 . However, although it is the same variant, phylogenetic differences between viruses isolated from Artibeus and Desmodus rotundus have already been demonstrated 22 , showing the great capacity of the virus to adapt to different hosts.…”

Section: Discussionsupporting

confidence: 92%

See 1 more Smart Citation

Circulation of the rabies virus in non-hematophagous bats in the city of Rio de Janeiro, Brazil, during 2001-2010

Cabral¹,

Morais²,

Dias³

et al. 2012

Rev. Soc. Bras. Med. Trop.

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Introduction: Rabies is one of the most known lethal zoonosis, responsible for 55,000 human deaths per year. It is transmitted to humans mainly by the bite of domestic or wild animals infected with the virus. This paper shows the circulation of this virus in non-hematophagous bats in the City of Rio de Janeiro, Brazil. Methods: A survey was performed on the number of bats that had been sent for diagnosis by the Seção de Virologia of the Instituto Municipal de Medicina Veterinária Jorge Vaitsman and were positive for rabies. The positive animals were identified, and the isolated viruses were sent for antigenic typification with indirect immunofluorescence. The results were compared with the antigenic panel of the Centers for Disease Control and Prevention. Results: During 2001-2010, the laboratory received 555 non-hematophagous bats for rabies diagnosis, with 198 (35.7%) from Rio de Janeiro City. A total of 11 (5.5%) animals were positive for this disease. Antigenic typification revealed the predominance of variant 3 in 9 (81.8%) of the isolated viruses; 1 virus was classified as variant 4 and 1 variant was identified that segregated with the viruses in insectivorous bats. Conclusions: The data obtained in this study showed the presence of the rabies virus in synanthropic populations of non-hematophagous bats in the City of Rio de Janeiro. The circulation of this agent in these animals represents a serious risk to human and animal health and requires attention and control measures by the authorities.

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Section: Discussionsupporting

confidence: 92%

“…However, although it is the same variant, phylogenetic differences between viruses isolated from Artibeus and Desmodus rotundus have already been demonstrated 22 , showing the great capacity of the virus to adapt to different hosts.…”

Section: Discussionmentioning

confidence: 99%

Circulation of the rabies virus in non-hematophagous bats in the city of Rio de Janeiro, Brazil, during 2001-2010

Cabral¹,

Morais²,

Dias³

et al. 2012

Rev. Soc. Bras. Med. Trop.

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“…Bats from the Molossus genus are among those most frequently found infected with RABV, probably due to the ecological and behavioral characteristics of the genus, increasing their susceptibility to become infected by specific variants from other bats, as observed in other studies (31,33,34).…”

Section: Discussionmentioning

confidence: 58%

Phylogenetic analysis of rabies surveillance samples from north and northeast Brazil

Cunha,

Silva,

Silva

et al. 2023

Front. Vet. Sci.

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Viruses of the Lyssavirus genus are classified into several genotypes (GT1 to GT7), of which only GT1 (classic rabies virus—RABV) has a cosmopolitan distribution and circulates in Brazil. GT1 is subdivided into several antigenic variants (AgV) maintained in independent cycles with a narrow host range and distinct geographic distributions, namely, AgV1 and AgV2 found in dogs, AgV3 in the vampire bats Desmodus rotundus, and AgV4 and AgV6 in bats non-hematophagous Tadarida brasiliensis and Lasiurus cinereus, a common variant of marmoset (Callithrix jacchus), and crab-eating fox (Cerdocyon thous). In this study, we performed phylogenetic analysis to identify at the antigenic variant level; six RABV genomes derived from the Rabies Surveillance in the north and northeast regions of Brazil. The analysis resulted in the formation of 11 monophyletic clusters, each corresponding to a particular variant, with high bootstrap support values. The samples were positioned inside the AgV3, AgV6, and Callithrix variant clades. This is the first report of the AgV6 variant found in northern Brazil, which provides valuable information for rabies surveillance in the country. The possibility of viral spillover has been much debated, as it deals with the risk of shifting transmission from a primary to a secondary host. However, more genomic surveillance studies should be performed, with a greater number and diversity of samples to better understand the transmission dynamics of each variant to detect changes in its geographic distribution and spillover events.

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“…). Porém resultados falsonegativos podem acontecer quando o teste for realizado diretamente em amostras clínicas sem o isolamento viral anterior em função de eventuais títulos virais baixos(FAHL, 2009). Para este estudo no qual foram utilizados diversos tecidos e órgãos para a detecção do vírus da raiva, podem ter ocorrido resultados falso-negativos na técnica de RT-PCR a qual diagnosticou positivas somente 40 amostras das 180 analisadas, resultando em uma sensibilidade de 56,25%.…”

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Detecção do vírus da raiva em órgãos de morcegos do gênero Artibeus (Leach, 1821) por meio de RT-PCR, Hemi-Nested RT-PCR e Real Time RT-PCR

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Filogenia de vírus da raiva isolados de morcegos frugívoros do gênero Artibeus e relacionados a morcegos hematófagos com base nos genes codificadores da nucleoproteína N e glicoproteína G

Cited by 3 publications

References 26 publications

Circulation of the rabies virus in non-hematophagous bats in the city of Rio de Janeiro, Brazil, during 2001-2010

Circulation of the rabies virus in non-hematophagous bats in the city of Rio de Janeiro, Brazil, during 2001-2010

Phylogenetic analysis of rabies surveillance samples from north and northeast Brazil

Detecção do vírus da raiva em órgãos de morcegos do gênero Artibeus (Leach, 1821) por meio de RT-PCR, Hemi-Nested RT-PCR e Real Time RT-PCR

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