Fimbriae and adhesive properties in salmonellae

Abstract

Berry, L. Joe (Bryn Mawr College, Bryn Mawr, Pa.), Dorothy S. Smythe, and Louise S. Colwell. Inhibition of inducible liver enzymes by endotoxin and actinomycin D. J. Bacteriol. 92:107-115. 1966.-Bacterial endotoxin at the ld(50) level lowers liver tryptophan pyrrolase in mice, it prevents for 16 to 20 hr the induction of the enzyme by a concurrent injection of cortisone, it lowers significantly but does not prevent substrate induction, and it reduces the enzymatic activity promptly and significantly when administered during the course of hormonal induction. The ld(50) amount of actinomycin D has a similar effect on tryptophan pyrrolase, except that its inhibition of induction by cortisone persists for a longer period of time. Endotoxin in the intact mouse induces tyrosine-alpha-ketoglutarate transaminase almost as well as cortisone, but not in the adrenalectomized animal, a fact that suggests induction of this enzyme is due to release of endogenous adrenal hormones. Actinomycin D, on the other hand, has an effect on this transaminase similar to that on tryptophan pyrrolase. The site of action of endotoxin and actinomycin D would appear to be similar for one of the two enzymes studied and different for the other, a relationship that requires a specificity difficult to imagine for a material as complex as endotoxin.

Correlation of phage type, biotype and source in strains ofSalmonella typhimurium

“…1975), over 600 of which had been examined for fimbriae and Kristensen biotype (Duguid, Anderson & Campbell, 1966), 20 of phage type 44 and 42 of phage types 196-209. About two-thirds of the cultures were collected at random on the basis that onfly one isolation was taken from each distinct epidemic incident, but there were also groups of cultures collected from different patients or animals in the same outbreaks.…”

“…Most of the cultures had been received at the Enteric Reference Laboratory for phage-typing, but the series also included collections supplied by colleagues (Duguid et al 1966). The 2092 cultures had been isolated between 1920 and 1975 in 57 countries (Table 1) and their sources were man, mostly patients with gastroenteritis, 40 other animal species, foodstuffs and sewage (Table 2).…”

Purification and Characterization of Type 1 Fimbriae of Salmonella typhi

“…In members of the genus Salmonella, production of type 1 fimbriae is a common feature (4) and, in host-adapted Salmonella serovars, these structures apparently represent the only adhesin present (4,10). In S. typhi, in particular, which is still a very impotant human pathogen (7), type 1 fimbriae are produced by the majority of strains of clinical origin (4, Muscas et al, unpublished) and have not yet been studied in detail.…”

The Fimbrial and Non-Fimbrial Haemagglutinins of Escherichia Coli

“…Their haemagglutinating activity was associated with the possession of filamentous appendages, named " fimbriae ", which were best developed in stationary-phase cultures grown serially in static liquid media. It was wholly inhibited in the presence of 0.5 % (w/v) D-mannose or methyl-alpha-D-mannoside (Duguid and Gillies, 1957) and the fimbriae with this mannose-sensitive (MS) activity were later classified as " type 1 " by Duguid, Anderson and Campbell (1966), Duguid (1968) and Ottow (1975).…”