Fimbristylis aestivalis Vahl: a potential source of cyclooxygenase-2 (COX-2) inhibitors

Talukder, Saduddin; Ahmed, Khondoker Shahin; Hossain, Hemayet; Hasan, Tarek; Liya, Israt Jahan; Amanat, Muhammed; Nahar, Nurun; Shuvo, Md. Sadikur Rahman; Daula, A F M Shahid Ud

doi:10.1007/s10787-022-01057-0

Cited by 6 publications

(3 citation statements)

References 40 publications

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“…Shimadzu LC- 20A system (Tokyo, Japan) was used to analyze the extract’s phenolic content. The instrument setup and solvent system were followed according to Talukder et al, 2022 ; Talukder et al, 2022 ). The following settings were used: injection volume of 20 L, 0.5 mL/min flow rate, 5%–25% solution A for the first 0.01–20 min, 25–40 min, 40–60 min, 60 to 35 min, 30%–5% minutes, and 5% minutes for the next 40–50 min.…”

Section: Methodsmentioning

confidence: 99%

“…Evidence also showed that rutin can effectively alleviate inflammation by decreasing the levels of pro-inflammatory markers such as TNF-α, IL-6, COX-2, IL-1β (Figure 9) (Hasan et al, 2022;Muvhulawa et al, 2022). The aforementioned polyphenols have been found in significant quantities in ZrlME.…”

Section: Bioactivity and Toxicity Risk Studiesmentioning

confidence: 98%

“…The most abundant polyphenols, (-) epicatechin, was reported to have a very stable interaction with COX-2 (Mazumder et al, 2022). Talukder et al (2022) also revealed the enduring association of rosmarinic acid (second most abundant polyphenols in ZrlME) with the active region of COX-2, signifying noteworthy inhibitory effect of ZrlME against COX-2 (Talukder et al, 2022). Possible mode of action for polyphenols identified in ZrlME in reducing inflammation.…”

Section: Bioactivity and Toxicity Risk Studiesmentioning

confidence: 99%

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Polyphenols and extracts from Zingiber roseum (Roxb.) Roscoe leaf mitigate pain, inflammation and pyrexia by inhibiting cyclooxygenase-2: an in vivo and in silico studies

Ahmed,

Rahman

et al. 2024

Front. Pharmacol.

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Zingiber roseum (Roxb.) Roscoe, a perennial herb from the Zingiberaceae family, has a long history of traditional use in the treatment of several ailments including pain, inflammation, fever, cough, arthritis, skin diseases, and liver infections. This study sought to confirm the efficacy of Zingiber roseum (Roxb.) Roscoe leaves methanol extract (ZrlME) as reported in traditional usage by evaluating its analgesic, anti-inflammatory, and antipyretic capabilities. In addition, in silico molecular docking of the metabolites identified in ZrlME was studied to verify the experimental outcomes. ZrlME demonstrated strong dose-dependent analgesic efficacy against all analgesic tests. ZrlME (400 mg/kg) showed higher anti-inflammatory activity than the standard in the carrageenan-induced paw edema test model. A significant reduction of rectal temperature (3.97°F↓) was also recorded at the same dose of ZrLME after 24 h of treatment. Seven polyphenolic metabolites were identified and quantified by HPLC-DAD analysis, including 3, 4- dihydroxy benzoic acid, (-) epicatechin, rutin hydrate, p-coumaric acid, trans-ferulic acid, rosmarinic acid, and myricetin. Strong binding affinities (ranges from −5.8 to −8.5 Kcal/mol) between the aforesaid polyphenols and cyclooxygenase-2 were discovered. Moreover, molecular dynamics simulations (MDS) demonstrated that these polyphenols exhibit significant COX-2 inhibitory activity due to their high stability in the COX-2 active site. In computational prediction, the polyphenols were also found to be nontoxic, and a variety of biological activities, such as antioxidant, analgesic, anti-inflammatory, antipyretic, and hepatoprotective, were observed. The results of this study revealed that ZrlME possesses notable analgesic, anti-inflammatory, and antipyretic properties.

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Section: Methodsmentioning

confidence: 99%

Section: Bioactivity and Toxicity Risk Studiesmentioning

confidence: 98%

Section: Bioactivity and Toxicity Risk Studiesmentioning

confidence: 99%

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