Final Report of EORTC 26951 and RTOG 9402 for Anaplastic Oligodendroglial Tumors

Abstract

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Reply to B. Zhao et al

“…Additionally, these updated data provide deeper insights into our understanding of the prognostic and predictive importance of molecular biomarkers. We believe that the meta-analysis reported by Zhao et al 1 does not enhance the reliability of our results because of the methodological concern noted above. Future analysis combining patient-level data from randomized studies with prolonged follow-up to further confirm the benefit of PCV is warranted.…”

“…Zhao et al 1 pointed out that because of the relatively favorable prognosis of these patients and the protracted clinical follow-up on our trials, some patients would have developed comorbidities and other noncancer disease conditions as they aged during the course of follow-up. However, the definitions of progression-free survival (PFS) and overall survival (OS) in both of our trials include all-cause mortality as the event of interest.…”

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We thank Zhao et al 1 for their careful reading and thoughtful comments on our article. 2 We appreciate the opportunity to address the methodological concerns raised and to comment on the mini metaanalysis undertaken by Zhao et al 1

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