Financial burden of hospital-acquired Clostridium difficile infection

Wilcox, Mark H.; Cunniffe, J.; Trundle, C.; Redpath, C.

doi:10.1016/s0195-6701(96)90122-x

Cited by 226 publications

(139 citation statements)

References 15 publications

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“…Although the majority of patients remain asymptomatic following acquisition of C difficile (5), it is still the most commonly identified cause of nosocomial diarrhea (5,11,12). While specific antibiotic therapy for C difficile has reduced morbidity and mortality among people with CDAD (13)(14)(15), evidence exists that C difficile infection contributes to patient morbidity (7,10) and significantly impacts hospital costs (15)(16)(17).…”

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confidence: 99%

“…Because elderly people and those exposed to large amounts of antibiotics have a higher risk of acquiring CDAD, they are commonly surveyed (15,20,21). Specific wards (eg, medical and surgical) where the rates of CDAD are higher are also more frequently studied (2,6,22,23).…”

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confidence: 99%

“…One British study specifically examined the costs of N-CDAD (15). However, all studies suggest that these costs are substantial, which include the expenses of caring for and treating patients with CDAD, combined with the costs associated with C difficile outbreaks (15)(16)(17).…”

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N‐CDAD in Canada: Results of the Canadian Nosocomial Infection Surveillance Program 1997 N‐CDAD Prevalence Surveillance Project

Hyland

Ofner-Agostini²,

Miller

et al. 2001

Canadian Journal of Infectious Diseases and Medical Microbiolog

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BACKGROUND:A 1996 preproject survey among Canadian Hospital Epidemiology Committee (CHEC) sites revealed variations in the prevention, detection, management and surveillance ofClostridium difficile-associated diarrhea (CDAD). Facilities wanted to establish national rates of nosocomially acquired CDAD (N-CDAD) to understand the impact of control or prevention measures, and the burden of N-CDAD on health care resources. The CHEC, in collaboration with the Laboratory Centre for Disease Control (Health Canada) and under the Canadian Nosocomial Infection Surveillance Program, undertook a prevalence surveillance project among selected hospitals throughout Canada.OBJECTIVE:To establish national prevalence rates of N-CDAD.METHODS:For six weeks in 1997, selected CHEC sites tested all diarrheal stools from inpatients for eitherC difficiletoxin orC difficilebacteria with evidence of toxin production. Questionnaires were completed for patients with positive stool assays who met the case definitions.RESULTS:Nineteen health care facilities in eight provinces participated in the project. The overall prevalence of N-CDAD was 13.0% (95% CI 9.5% to 16.5%). The mean number of N-CDAD cases were 66.3 cases/100,000 patient days (95% CI

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N‐CDAD in Canada: Results of the Canadian Nosocomial Infection Surveillance Program 1997 N‐CDAD Prevalence Surveillance Project

Hyland

Ofner-Agostini²,

Miller

et al. 2001

Canadian Journal of Infectious Diseases and Medical Microbiolog

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“…US estimates fall within a similar range 12 . A UK study estimated that each 5% reduction in in MRSA or C. difficile cases reduced national costs by £4.9 million annually 13 , but other UK estimates are now out of date 14 . A Canadian study provided limited evidence that the cost of readmissions for further treatment following C. difficile infections can be high 15 .…”

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confidence: 99%

Management of patients with suspected infectious diarrhoea in hospitals in England

Buchanan

Wordsworth

O’Connor

et al. 2015

Journal of Hospital Infection

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Word count Summary 249 (limit 250) 5 Tables (200 words each) 1000 All text (including summary, acknowledgements, and references) 3401 Total word count (including all text and tables) 4401 (limit 4000) 2 SUMMARYBackground: Advances in molecular and genomic testing for patients with suspected infectious diarrhoea are on the horizon. It is important to understand how infection control and microbiology departments currently operate with respect to the management of these patients in order to assess the implications of more widespread diagnostic testing. However, there are few data available on current practice in this context.

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“…Diagnosing accurately the microbial cause of each nosocomial infection becomes ever more important when one considers the need to limit the spread of hospital pathogens from patient to patient. It is very difficult to enforce infection prevention and control measures without laboratory support [7]. Outbreaks can continue indefinitely in hospitals and remain totally undetected.…”

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confidence: 99%

Clinical Microbiology Services are Essential for Diagnosis, Treatment and Prevention of MRSA and Other Nosocomial Pathogens in Libyan Healthcare Facilities

El-Bouri¹

2009

Libyan J Med

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Financial burden of hospital-acquired Clostridium difficile infection

Cited by 226 publications

References 15 publications

N‐CDAD in Canada: Results of the Canadian Nosocomial Infection Surveillance Program 1997 N‐CDAD Prevalence Surveillance Project

N‐CDAD in Canada: Results of the Canadian Nosocomial Infection Surveillance Program 1997 N‐CDAD Prevalence Surveillance Project

Management of patients with suspected infectious diarrhoea in hospitals in England

Clinical Microbiology Services are Essential for Diagnosis, Treatment and Prevention of MRSA and Other Nosocomial Pathogens in Libyan Healthcare Facilities

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