Finasteride administration potentiates the disruption of prepulse inhibition induced by forced swim stress

Pallarès, Marc; Llidó, Anna; Mòdol, Laura; Vallée, Monique; Darbra, Sònia

doi:10.1016/j.bbr.2015.04.023

Cited by 8 publications

(3 citation statements)

References 55 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…allopregnanolone exhibited anxiolytic and antidepressant effects in the preclinical and clinical studies (Pallarès et al, 2015;Pinna and Rasmusson, 2012). Importantly, the allopregnanolone played a significant role in the treatment of depression and anxiety.…”

Section: Accepted Manuscriptmentioning

confidence: 98%

Translocator protein mediates the anxiolytic and antidepressant effects of midazolam

Qiu

et al. 2015

Pharmacology Biochemistry and Behavior

View full text Add to dashboard Cite

Section: Accepted Manuscriptmentioning

confidence: 98%

Translocator protein mediates the anxiolytic and antidepressant effects of midazolam

Qiu

et al. 2015

Pharmacology Biochemistry and Behavior

View full text Add to dashboard Cite

“…Alopecia has likewise been seen as significant symptom of anticancer medications, immunosuppressant and numerous other medication therapies. Mental stun, enthusiastic strain, central disease, mistakes of refraction, endocrine aggravation, neurocirculation unsteadiness and hereditary inclination are additionally the known reason for alopecia [8].…”

Section: Alopecia (Hair Loss)mentioning

confidence: 99%

Exploring the potential of herbal drugs for the treatment of hair loss

Bartere

Malode

Malode³

et al. 2021

GSC Biol. and Pharm. Sci.

View full text Add to dashboard Cite

Hair loss can be recognized as a life-threatening disorder. It is a health condition during which hair is lost from some or all areas of the body, usually from the scalp. However, it has a great harm to a person’s self-respect, mental health, and entirety quality of life. Balding can be caused because of various reasons, like genetic tendencies, environmental triggers, exposure to chemicals, medicines, nutritional deficiency, extreme stress or long illness etc. In present article, we have covered information about loss of hair loss, types of alopecia, causes and various medicinal plants and parts they’re of used in treatment prophylaxis or treatment of hair loss.

show abstract

“…Lowered levels of allopregnanolone may lead to imbalance in excitatory neurotransmission that causes depressive symptoms17. Conversely, allopregnanolone exerts antidepressant-like effects in preclinical and clinical studies1618. However, the relationship between allopregnanolone and depression in T2DM has not yet fully understood.…”

mentioning

confidence: 99%

The antidepressant-like activity of AC-5216, a ligand for 18KDa translocator protein (TSPO), in an animal model of diabetes mellitus

Qiu

He²,

Liu

et al. 2016

Sci Rep

View full text Add to dashboard Cite

Diabetes mellitus is a chronic disease that is associated with depression. Also, depression is common in adults with type 2 diabetes mellitus (T2DM). Translocator protein (18kDa) (TSPO) and allopregnanolone play an important role in the depression treatment. However, few studies have evaluated TSPO and allopregnanolone in the treatment of depression in T2DM. AC-5216, a ligand for TSPO, produces anxiolytic- and antidepressant-like effects in animal models. The present study aimed to explore antidepressant-like effects of AC-5216 on diabetic rats. Following the development of diabetic model induced by high fat diet (HFD) feeding and streptozotocin (STZ), AC-5216 (0.3 and 1 mg/kg, i.g.) elicited the antidepressant-like effects in behavioral tests while these activities were blocked by TSPO antagonist PK11195 (3 mg/kg, i.p.). The levels of allopregnanolone in the prefrontal cortex and hippocampus were increased by AC-5216 (0.3 and 1 mg/kg, i.g.), which was antagonized by PK11195 (3 mg/kg, i.p.). The increased plasma glucose (PG) and decreased insulin (INS) in HFD-STZ rats were reversed by AC-5216 (0.3 and 1 mg/kg, i.g.). This study indicates that the antidepressant-like effects of AC-5216 on HFD-STZ rats, suggesting that TSPO may represent a novel therapeutic target for depression in T2DM.

show abstract

Finasteride administration potentiates the disruption of prepulse inhibition induced by forced swim stress

Cited by 8 publications

References 55 publications

Translocator protein mediates the anxiolytic and antidepressant effects of midazolam

Translocator protein mediates the anxiolytic and antidepressant effects of midazolam

Exploring the potential of herbal drugs for the treatment of hair loss

The antidepressant-like activity of AC-5216, a ligand for 18KDa translocator protein (TSPO), in an animal model of diabetes mellitus

Contact Info

Product

Resources

About