Finding Influencing factors and probability to develop Diabetes Mellitus among adult hypertensive population in Puducherry (UT), South India: Hospital based retrospective study

Vasudevan, S; Sathiyamoorthi, R; Sumathi, S; Jayanthi, V.

doi:10.9790/0853-131219397

Cited by 2 publications

(1 citation statement)

References 12 publications

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“…Diabetes mellitus (DM) refers to a group of metabolic disorders [ 1 ]. The primary complications that occur as a result of diabetes caused by blood vessel damage include damage to the nerves, eyes, and kidneys, which are clinically referred to as diabetic neuropathy, diabetic retinopathy, and diabetic nephropathy, respectively [ 2 ].…”

Section: Introductionmentioning

confidence: 99%

Association of single nucleotide polymorphisms in CACNA 1A/CACNA 1C/CACNA 1H calcium channel genes with diabetic peripheral neuropathy in Chinese population

Sun

Mao

et al. 2018

Bioscience Reports

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The present study was conducted to explore the correlations between single nucleotide polymorphisms (SNPs) in the calcium channel CACNA 1A, CACNA 1C, and CACNA 1H genes and diabetic peripheral neuropathy (DPN) amongst the Chinese population. In total, 281 patients diagnosed with type 2 diabetes participated in the present study. These patients were divided into the case group, which was subdivided into the DPN (143 cases) and the non-DPN groups (138 cases). Subsequently, 180 healthy individuals that had undergone routine health examinations were also recruited and assigned to the control group. PCR-restriction fragment length polymorphism (PCR-RFLP) was used to detect the genotype and allele frequencies of CACNA 1A, CACNA 1C, and CACNA 1H genes; logistic regression analysis to investigate the association of gene polymorphisms with DNP. Gene-gene interactions were then detected by generalized multifactor dimensionality reduction (GMDR). The results revealed that CACNA 1A rs2248069 and rsl6030, CACNA 1C rs216008 and rs2239050, and CACNA 1H rs3794619, and rs7191246 SNPs were all associated with DPN, while rs2248069, rsl6030, rs2239050, and rs7191246 polymorphisms were attributed to the susceptibility to DPN. It was also observed that the optimal models were three-, four- and five-dimensional models with a prediction accuracy of 61.05% and the greatest consistency of cross-validation was 10/10. In summary, these findings demonstrated that the SNPs in the CACNA 1A, CACNA 1C, and CACNA 1H genes were involved in the pathophysiology of DPN. In addition, polymorphisms in the CACNA 1A, CACNA 1C, and CACNA 1H genes and their interactions also had effects on DPN.

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Section: Introductionmentioning

confidence: 99%

Association of single nucleotide polymorphisms in CACNA 1A/CACNA 1C/CACNA 1H calcium channel genes with diabetic peripheral neuropathy in Chinese population

Sun

Mao

et al. 2018

Bioscience Reports

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Influencing factors of vision-threatening disease among patients with diabetes in the central region of Saudi Arabia: A case–control study

Alsolaimi

Almudaymigh

Essa

et al. 2022

Journal of Family Medicine and Primary Care

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Aims: Diabetic retinopathy is called as vision threatening disease. It affects retina very severely. DR is a common public health problem in Worldwide. Our main objective was to identify significant risk factors for diabetic retinopathy among diabetes mellitus patients. Materials and Methods: The present retrospective Case-Control study was conducted with 404 DM patients’ records were collected from King Abdulaziz Medical City, Riyadh, Saudi Arabia. Statistical analysis used: Data were presented as descriptive statistics, multivariate logistic regression, association between variables was using odds ratio and 95% confidence interval. Results: Among 404 diabetes patients, 192 (47.5%) were Cases and 212 (52.5%) Controls. In multivariate regression analysis showed that male gender also had a higher likelihood in the development of DR, OR: 1. 68 [95% CI: (1.04 – 2.71); p<0.05]. Patients with poor glycaemic control, OR: 4. 86 [95% CI: (2.21-10.66); p<0.001]. Similarly, HbA1C, Low LDL was prominent risk factor in the progression of DR except age, hypocholesterolaemia, nephropathy wasn’t significant. Conclusions: From our study findings, male gender, tobacco habit, poor glycaemic control, and Low HDL were appeared independently associated with the development of vision-threatening disease. By regular check-up, reducing risk factors or retain their stages in the same stage or to prolong the DR incidents among DM patients.

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Finding Influencing factors and probability to develop Diabetes Mellitus among adult hypertensive population in Puducherry (UT), South India: Hospital based retrospective study

Abstract: 39.84 ± 7.65 (range: 20 -65) in mg/dl, 70.63 ± 11.94 (range: 44 -116) in mg/dl, and 6.22 ± 3.82 years (3 -24 years)

Cited by 2 publications

References 12 publications

Association of single nucleotide polymorphisms in CACNA 1A/CACNA 1C/CACNA 1H calcium channel genes with diabetic peripheral neuropathy in Chinese population

Association of single nucleotide polymorphisms in CACNA 1A/CACNA 1C/CACNA 1H calcium channel genes with diabetic peripheral neuropathy in Chinese population

Influencing factors of vision-threatening disease among patients with diabetes in the central region of Saudi Arabia: A case–control study

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