BACKGROUND: Despite a growing need for primary care physicians in the United States, the proportion of medical school graduates pursuing primary care careers has declined over the past decade. OBJECTIVE: To assess the association of medical school research funding with graduates matching in family medicine residencies and practicing primary care. KEY RESULTS: Among research-intensive medical schools, the 16 private medical schools produced significantly fewer practicing primary care physicians (median 24.1 % vs. 33.4 %, p<0.001) and fewer recent graduates matching in family medicine residencies (median 2.4 % vs. 6.2 %, p<0.001) than the other 30 private schools. In contrast, the nine research-intensive public medical schools produced comparable proportions of graduates pursuing primary care careers (median 36.1 % vs. 36.3 %, p =0.87) and matching in family medicine residencies (median 7.4 % vs. 10.0 %, p=0.37) relative to the other 66 public medical schools. CONCLUSIONS: To meet the health care needs of the US population, research-intensive private medical schools should play a more active role in promoting primary care careers for their students and graduates.