Finding synaptic couplings from a biophysical model of motor evoked potentials after theta-burst transcranial magnetic stimulation

Wilson, Marcus T.; Goldsworthy, Mitchell R.; Vallence, Ann-Maree; Fornito, Alex; Rogasch, Nigel C.

doi:10.1016/j.brainres.2022.148205

Cited by 1 publication

(1 citation statement)

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“…We cannot exclude the possibility, however, that subthreshold pulses would reveal a stimulus-intensity dose-response in the DLPFC. There is considerable evidence that properties of sigmoidal TMS-EMG input–output curves are sensitive to iTBS effects 50 – 53 . Therefore, future research should evaluate the full range of TEP properties in DLPFC to determine whether a similar sigmoidal function is present and its practical applicability to plasticity-inducing protocols.…”

Section: Discussionmentioning

confidence: 99%

A dose-response characterization of transcranial magnetic stimulation intensity and evoked potential amplitude in the dorsolateral prefrontal cortex

Krile,

Ensafi,

Cole

et al. 2023

Sci Rep

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By combining transcranial magnetic stimulation (TMS) with electroencephalography, human cortical circuits can be directly interrogated. The resulting electrical trace contains TMS-evoked potential (TEP) components, and it is not known whether the amplitudes of these components are stimulus intensity dependent. We examined this in the left dorsolateral prefrontal cortex in nineteen healthy adult participants and extracted TEP amplitudes for the N40, P60, N120, and P200 components at 110%, 120%, and 130% of resting motor threshold (RMT). To probe plasticity of putative stimulus intensity dose-response relationships, this was repeated after participants received intermittent theta burst stimulation (iTBS; 600 pulses, 80% RMT). The amplitude of the N120 and P200 components exhibited a stimulus intensity dose-response relationship, however the N40 and P60 components did not. After iTBS, the N40 and P60 components continued to exhibit a lack of stimulus intensity dose-dependency, and the P200 dose-response was unchanged. In the N120 component, however, we saw evidence of change within the stimulus intensity dose-dependent relationship characterized by a decrease in absolute peak amplitudes at lower stimulus intensities. These data suggest that TEP components have heterogeneous dose-response relationships, with implications for standardizing and harmonizing methods across experiments. Moreover, the selective modification of the N120 dose-response relationship may provide a novel marker for iTBS plasticity in health and disease.

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Section: Discussionmentioning

confidence: 99%