Finding the sweet spot: glycosylation mediated regulation of intestinal inflammation

Brazil, Jennifer; Parkos, Charles A.

doi:10.1038/s41385-021-00466-8

Cited by 34 publications

(31 citation statements)

References 194 publications

(182 reference statements)

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“…The expression of some biomolecules like inflammatory biomarkers in the injured colon is increased during IBD development compared with their basic expression level in normal physiological conditions ( Figures 1C,F ). The overexpression of glycoprotein CD98, CD44, and folate receptor is among the most important pathophysiological changes in the injured colon ( Naserifar et al, 2020 ; Brazil and Parkos, 2022 ; Rahiman et al, 2022 ). On the other hand, it is noteworthy that expression of some biomolecules on the surface of capillary endothelial cells raises in the inflamed colon.…”

Section: Pathophysiological Changes In the Gastrointestinal Tract Of ...mentioning

confidence: 99%

“…Another example of changes in the expression of biomolecules is the overexpression of CD44 in the inflamed colon ( Lee et al, 2021 ; Lima et al, 2021 ; Brazil and Parkos, 2022 ; Kotla et al, 2022 ). CD44 is a principal cell surface receptor for hyaluronic acid, a main component present in the extracellular matrix.…”

Section: Targeting Pathophysiological Changes Using Biomaterials-base...mentioning

confidence: 99%

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Targeting pathophysiological changes using biomaterials-based drug delivery systems: A key to managing inflammatory bowel disease

et al. 2022

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Inflammatory bowel disease (IBD) is a gastrointestinal disorder, affecting about several million people worldwide. Current treatments fail to adequately control some clinical symptoms in IBD patients, which can adversely impact the patient’s quality of life. Hence, the development of new treatments for IBD is needed. Due to their unique properties such as biocompatibility and sustained release of a drug, biomaterials-based drug delivery systems can be regarded as promising candidates for IBD treatment. It is noteworthy that considering the pathophysiological changes occurred in the gastrointestinal tract of IBD patients, especially changes in pH, surface charge, the concentration of reactive oxygen species, and the expression of some biomolecules at the inflamed colon, can help in the rational design of biomaterials-based drug delivery systems for efficient management of IBD. Here, we discuss about targeting these pathophysiological changes using biomaterials-based drug delivery systems, which can provide important clues to establish a strategic roadmap for future studies.

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Section: Pathophysiological Changes In the Gastrointestinal Tract Of ...mentioning

confidence: 99%

Section: Targeting Pathophysiological Changes Using Biomaterials-base...mentioning

confidence: 99%

Targeting pathophysiological changes using biomaterials-based drug delivery systems: A key to managing inflammatory bowel disease

et al. 2022

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“…In light of the "signal" detected and reported in the Gundry Abstracts [7,8], perhaps primed by prior dietary gluten and lectin sensitization [170][171][172][173], and provoked by subsequent polynucleotide (nucleic acid) inoculation [39], it will be very important to look at the time course of various biomarker elevations, e.g. IL-16, Fas, and HGF levels, during the SSP [174][175][176].…”

Section: Urgent Need For Additional Case-control Studies Of Temporal ...mentioning

confidence: 99%

“…Fucosyl transfers to endogenous biological nucleophiles has gained recognition as playing an important role in immune recognition during the human immune response [153,154,171]. Post-translational modification (PTMs) of proteins is thought to take place at or near the Golgi apparatus of the endoplasmic reticulum [172,173]. L-AA is thought to mitigate oxidative endoplasmic reticulum (ER) stress [156,[230][231][232]257] .…”

Section: Proposed Means For Delivery Of L-fucose To the Golgi Apparat...mentioning

confidence: 99%

Are the mRNA vaccines inducing the Sanarelli-Shwartzman phenomenon?

Davidson¹,

Winey²

2022

GSC Adv. Res. Rev.

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Adverse events of myocarditis, pericarditis, and thrombosis, temporally associated with mRNA vaccination(s) and/or mRNA vaccine boosters, have been reported during post-marketing safety surveillance in the U.S. CDC VAERS database and 2021 CDC guidance to physicians. An interim report unexpectedly revealed inflammatory biomarker elevations in vaccine recipients. During review of considerable published research on the Sanarelli-Shwartzman phenomenon (SSP) and the use of nucleic acids as vaccine adjuvants, a novel, hypothesis is proposed. Even today, after being studied for over a century, the pathophysiology of the SSP is not fully understood. Motivated by a paper from 1950, titled “General Adaptation Syndrome” by Hans Selye, and recent published research by Korean investigators, a novel, non-conventional hypothesis was generated. Gluten and lectin sensitivity are cited as examples of sensitizing events of the SSP, for which we propose ensemble hydrophobic chiroptical catalysis may have therapeutic benefit. Under the ensemble HCC hypothesis, we propose that inflammatory stress and scurvy promote loss of chirality control, anomeric fidelity, phenotypic stability, and immune function, both humoral and cell-mediated, with the dialyzable transfer factor, L-ascorbic acid, and spin water playing central roles. It is proposed that therapeutic synergy of L-ascorbic acid, bioflavonoids, and corticosteroids in countering the SARS-CoV-2 pathogen arises from memory of chirality which originated during their biosynthesis. It is proposed that ensemble HCC is powered by radiant and or zero-point energy (quantum vacuum fluctuations) which may support a paradigm shift to supramolecular biology. The distinction between supramolecular biology and supramolecular xenobiology is highlighted.

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“…We read with enthusiasm the recent review by Brazil and Parkos 'Finding the sweet spot: glycosylation mediated regulation of intestinal inflammation' in Mucosal Immunology 1 . The authors have elegantly summarised the literature in relation to how chronic inflammation induces changes in intestinal and immune cell glycosylation.…”

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confidence: 99%

Some additional considerations on: “Finding the sweet spot: glycosylation mediated regulation of intestinal inflammation”

2022

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Finding the sweet spot: glycosylation mediated regulation of intestinal inflammation

Cited by 34 publications

References 194 publications

Targeting pathophysiological changes using biomaterials-based drug delivery systems: A key to managing inflammatory bowel disease

Targeting pathophysiological changes using biomaterials-based drug delivery systems: A key to managing inflammatory bowel disease

Are the mRNA vaccines inducing the Sanarelli-Shwartzman phenomenon?

Some additional considerations on: “Finding the sweet spot: glycosylation mediated regulation of intestinal inflammation”

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