Findings of OCT‐angiography compared to fluorescein and indocyanine green angiography in central serous chorioretinopathy

Min, Jingyu; Lv, Yanan; Yu, Shizhu; Gong, Yuanyuan

doi:10.1002/lsm.22952

Cited by 14 publications

(14 citation statements)

References 20 publications

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“…One assumption is that choroidal congestion characterizing CSCR may be accompanied with sluggish choriocapillaris flow caused by mechanical back pressure changes by the dilated large choroidal vessels, thus falling below OCTA detectable threshold [26]. Another explanation is the shielding effect of the overlying detached retina and subretinal fluid leading to impairment of signal transmission, and creating false flow impairment [13,27]. Moreover, it is possible that side walls of both the detached retina and underlying pigment epithelium detachment (PED) may provide additional sources of choriocapillaris signal attenuation.…”

Section: Discussionmentioning

confidence: 99%

“…CSCR characterization has been further validated through multiple imaging modalities including fluorescein angiography (FA) [13], fundus auto fluorescence (FAF) [14,15], optical coherence tomography (OCT) [16,17], and indocyanine green angiography (ICGA) [18,19]. Recently, optical coherence tomography angiography (OCTA) has been introduced as a non-invasive imaging modality enabling in-vivo angiographic visualization of different retinal and choroidal disorders [20].…”

Section: Open Accessmentioning

confidence: 99%

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Choriocapillaris Island: an optical coherence tomography angiography finding observed in central serous chorioretinopathy

Estawro¹,

Fayed

Gerges³

et al. 2021

Int J Retin Vitr

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Purpose To report the observation of the choriocapillaris island (CCI) on optical coherence tomography angiography (OCTA) in eyes with active central serous chorioretinopathy (CSCR), and to investigate its associated clinical features. Design Retrospective observational study. Methods Patients diagnosed with active CSCR underwent OCTA imaging (Optovue Inc, Fremont, California, USA), and the software built-in en face choriocapillaris slab was examined to demonstrate CCI, defined as an area of detectable choriocapillaris flow surrounded by an area of undetectable or diminished flow. Electronic medical records (EMR) were reviewed for demographics, clinical data, other imaging modalities and any intervention, and these parameters were correlated with CCI findings. Results 25 eyes of 25 patients were recruited. CCI was detected in all examined eyes and was best elucidated on the en face choriocapillaris density maps. 24 eyes had focal retinal pigment epithelium (RPE) alterations overlying CCI. All 14 eyes with simultaneous fundus fluorescein angiography (FA) showed actively leaking point(s) well corresponding to the CCI location. Resolution of sub-retinal fluid in 4 eyes was associated with disappearance of CCI on follow-up OCTA scans. 1 eye showed complicating neovascularization 5 months after the initial presentation at the same location of the CCI. Conclusion We demonstrate the observation of the “choriocapillaris island” an OCTA finding in eyes with active CSCR underneath the area of neurosensory detachment. CCI may constitute an angiographic representation of the focal area of choriocapillaris structural and functional affection, with secondary RPE alteration jeopardizing its barrier function. Larger longitudinal studies are needed to further elucidate this finding.

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Section: Discussionmentioning

confidence: 99%

Section: Open Accessmentioning

confidence: 99%

Choriocapillaris Island: an optical coherence tomography angiography finding observed in central serous chorioretinopathy

Estawro¹,

Fayed

Gerges³

et al. 2021

Int J Retin Vitr

View full text Add to dashboard Cite

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“…Thus, higher-resolution tools like OCTA may help visualize CNV noninvasively. In our previous study, it was essential to combine the cross-sectional OCTA B-scan images to confirm the signs of blood breaking Bruch’s membrane [22]. However, due to artifacts, the restrictions of automatic layering, and the diversity of lesion morphologies, this has its own limitations.…”

Section: Discussionmentioning

confidence: 99%

Multimodal Imaging in Fibrinous Central Serous Chorioretinopathy Compared with Exudative Maculopathy

Lyu

Gong

2020

Ophthalmologica

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Aims: To analyze ocular fundus characteristics of patients finally diagnosed with fibrinous central serous chorioretinopathy (CSC) using multimodal imaging and compare the characteristics with images of other confusable exudative maculopathies. Methods: We retrospectively reviewed the records from 189 patients with CSC and found records on 16 patients with fibrinous CSC. Some of these 16 patients were misdiagnosed with another exudative maculopathy and were treated inappropriately. Multimodal imaging comprised fundus photography, spectral-domain optical coherence tomography (OCT), fluorescein angiography (FA), indocyanine green angiography (ICGA), and OCT angiography (OCTA), and the results were compared with those of other exudative maculopathy patients from this study. Results: Twenty-one eyes of 16 patients with a mean age of

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“…Other non-invasive imaging systems that have been used or currently under development for evaluation of dermal vasculatures include laser Doppler flowmeter, laser Doppler imaging, dermoscopy, cross-polarized diffuse reflection color imaging system, and optical coherence tomography [39][40][41][42][43][44][45][46][47][48]. The main feature of RCM is that it can directly reveal the dermal structure in a simple and fast way, which makes it be a promising bedside tool for prognostic evaluation.…”

Section: Discussionmentioning

confidence: 99%

Characterization of Laser‐Resistant Port Wine Stain Blood Vessels Using In Vivo Reflectance Confocal Microscopy

Huang

Xiang

et al. 2019

Lasers Surg Med

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Background and Objectives Port wine stain (PWS) is a congenital vascular malformation of the human skin. Laser is the treatment of choice for PWS. Laser‐resistant PWS is one crucial factor accounting for inadequate treatment outcome, which needs to be fully characterized. This study aims to quantitatively characterize the morphology of laser‐resistant PWS blood vessels in the upper papillary dermis using in vivo reflectance confocal microscopy (RCM). Study Design/Materials and Methods A total of 42 PWS subjects receiving laser treatment from August 2016 through July 2018 were enrolled into this study. Thirty‐three subjects had facial PWS; nine had extremity PWS. All subject's PWS received multiplex 585/1,064 nm laser treatment. RCM images were taken before and after treatment. The density, diameter, blood flow, and depth of PWS blood vessels were analyzed. Results We found 44.4% PWS on the extremities (four out of nine subjects) were laser‐resistant, which was significantly higher (P < 0.001) when compared with those PWS on the face (15.2%, 5 out of 33 subjects). The laser‐resistant facial PWS blood vessels had significantly higher blood flow (1.35 ± 0.26 U vs. 0.89 ± 0.22 U, P < 0.001), larger blood vessel diameters (109.60 ± 18.24 µm vs. 84.36 ± 24.04 µm, P = 0.033) and were located deeper in the skin (106.01 ± 13.87 µm vs. 87.82 ± 12.57 µm, P < 0.001) in the skin when compared with laser‐responsive PWS on the face. The average PWS blood vessel density (17.01 ± 4.63/mm2 vs. 16.61 ± 4.44/mm2, P = 0.857) was not correlated to the laser resistance. Conclusions Laser‐resistant PWS blood vessels had significantly higher blood flow, larger diameters, and were located deeper in the skin. RCM can be a valuable tool for a prognostic evaluation on laser‐resistant lesions before treatment, thereby providing guidance for tailored laser treatment protocols, which may improve the therapeutic outcome. The limitations for this study include relative small sample size and acquisitions of different blood vessels before and after 2 months of treatment. Lasers Surg. Med. © 2019 Wiley Periodicals, Inc.

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Findings of OCT‐angiography compared to fluorescein and indocyanine green angiography in central serous chorioretinopathy

Cited by 14 publications

References 20 publications

Choriocapillaris Island: an optical coherence tomography angiography finding observed in central serous chorioretinopathy

Choriocapillaris Island: an optical coherence tomography angiography finding observed in central serous chorioretinopathy

Multimodal Imaging in Fibrinous Central Serous Chorioretinopathy Compared with Exudative Maculopathy

Characterization of Laser‐Resistant Port Wine Stain Blood Vessels Using In Vivo Reflectance Confocal Microscopy

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