2009
DOI: 10.1021/cg901038g
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Fine Dosage of Antisolvent in the Crystallization of l-Histidine: Effect on Polymorphism

Abstract: In this work, the antisolvent membrane crystallization process has been used to influence the polymorphic composition in the crystallization of L-histidine. When finely dosing the amount of ethanol in the crystallizing solution, by generating the proper trans-membrane flux, the composition of the precipitate shifts regularly from the prevalence of the thermodynamic stable polymorph A toward the predominance of the metastable phase B. Form A crystals are always the first to nucleate, thus following an "anti-Os… Show more

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Cited by 33 publications
(28 citation statements)
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“…In addition, the membrane distillation technology was also reported as the antisolvent addition devices (Drioli et al, 2012;Profio et al, 2010), and well-designed interpretation model of antisolvent crystallization was also proposed (Mostafa Nowee et al, 2008;Sangwal, 2010), which explored a potential application of the MDR technology to the MSZW of antisolvent crystallization process.…”
Section: Effect Of Parameters and Further Discussion On Mdr Technologymentioning
confidence: 99%
“…In addition, the membrane distillation technology was also reported as the antisolvent addition devices (Drioli et al, 2012;Profio et al, 2010), and well-designed interpretation model of antisolvent crystallization was also proposed (Mostafa Nowee et al, 2008;Sangwal, 2010), which explored a potential application of the MDR technology to the MSZW of antisolvent crystallization process.…”
Section: Effect Of Parameters and Further Discussion On Mdr Technologymentioning
confidence: 99%
“…The most common approach to antisolvent addition is a batch droplet or capillary‐based mixing . The limited interfacial mass transfer area used for the droplet approach and the undesired mixing result in a wide particle‐size distribution and an irregular crystal morphology, which are the fatal drawbacks for pharmaceutical and other chemical manufacture.…”
Section: Introductionmentioning
confidence: 99%
“…31 When the undersaturated Na 2 CO 3 concentration reaches supersaturation due to the gradual concentrated solution in the feed side, crystal nucleation and growth is carried out in the FO membrane crystallizer across a well-controlled pathway by gradually adjusting the supersaturation of target solutions via a membrane. 32 Thus, the size, shape, and purity of crystals can be more easily controlled through the controllable supersaturation rate of the feed stream. 33,34 For the application of FO technology in membrane crystallization, the membranes with a perfect performance are required.…”
Section: Introductionmentioning
confidence: 99%