Fine mapping a quantitative trait locus on horse chromosome 2 associated with radiological signs of navicular disease in Hanoverian warmblood horses

Lopes, M. S.; Diesterbeck, Ulrike S.; Machado, Artur da Câmara; Distl, O.

doi:10.1111/j.1365-2052.2009.01923.x

Cited by 5 publications

(2 citation statements)

References 9 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…A number of potential changes can result from one or many factors. On the basis of molecular studies it was concluded that there are genetic conditions making an individual horse prone to navicular disease, however, genes that could code for this defect are numerous LOPES et al 2009). These studies have determined specific regions on chromosomes with nucleotide polymorphisms responsible for dysfunction which may contribute to the development of navicular syndrome.…”

Section: Discussionmentioning

confidence: 99%

Changes in Navicular Bone (os sesamoideum distale) Shape in Horses as a Result of Pathological Alterations

Komosa¹,

Purzyc²,

Fraackowiak³

2013

folia biol (krakow)

View full text Add to dashboard Cite

The main aim of the study was to compare the shape of navicular bones classified as normal and pathologically changed. A comparison of metric features of the navicular bone between different types of horses and associating the examined parameters to the size of the middle and distal phalanges was an additional aspect of the study. The material comprised 53 horses of various breeds which were divided into three types. Through anatomical examinations it was concluded that as many as 30 navicular bones were normal, while 23 were found to present pathological changes. The following methods of statistical analysis were used: Levene's test, one-way ANOVA, T-test, LSD test and Pearson correlation. The shape of the navicular bone was described by seven indices developed for this purpose. From among them, three show statistically higher values in the affected bones compared to the healthy ones. The main result of the study is that navicular bones with defects are relatively thicker and have a higher flexor surface and a higher articular surface for the joint with the middle phalanx. Therefore our hypothesis is that the occurrence of pathological changes of the navicular bone is preceded by an increase in the thickness and height of this bone. Adverse changes occur only in the subsequent stage of the process. The study also revealed the interrelations between the phalanges and some metric features of the navicular bone. There were strong correlations between the breadth of the middle and distal phalanx, and the breadth and thickness of the navicular bone. Also, the height of the flexor surface of the navicular bone is strongly correlated with the breadth of the phalanges.

show abstract

Section: Discussionmentioning

confidence: 99%

Changes in Navicular Bone (os sesamoideum distale) Shape in Horses as a Result of Pathological Alterations

Komosa¹,

Purzyc²,

Fraackowiak³

2013

folia biol (krakow)

View full text Add to dashboard Cite

show abstract

“…The second approach takes advantage of historical recombinants to refine the location of QTL. For example, haplotype analysis utilizes historical recombinants to fine‐map the QTL of interest (Lopes et al. 2009).…”

Section: Introductionmentioning

confidence: 99%

Fine-mapping of quantitative trait loci for body weight and bone traits and positional cloning of the RB1 gene in chicken

Zhang

Liu

Zhang

et al. 2011

Journal of Animal Breeding and Genetics

View full text Add to dashboard Cite

Previously, a quantitative trait locus (QTL) that affects body weight (BW) at 4-12 weeks of age and carcass weight at 12 weeks of age had been mapped on chicken chromosome 1. After including more markers and individuals, the confidence interval was narrowed down to approximately 5.5 Mbps and located this QTL near a microsatellite marker (ADL328). This QTL is the same as the QTL for 12 bone traits, including metatarsus length and metatarsus circumference at 4, 6, 8, 10 and 12 weeks of age and keel length and metatarsus claw weight at 12 weeks of age, that was identified using the same population. In the current study, 1010 individuals from the Northeast Agricultural University F(2) resource population were used and 14 single-nucleotide polymorphism (SNPs) around ADL328 were developed to construct haplotypes, and an association analysis was performed to fine-map the QTL. The haplotypes were constructed on the basis of a sliding 'window', with three SNP markers included in each 'window'. The association analysis results indicated that the haplotypes in 'windows' 6-12 were significantly associated with BW and bone traits and suggested that the QTL for BW and bone traits was located between SNP8 and SNP14 or was in linkage disequilibrium with this region. The interval from SNP8 to SNP14 was approximately 400 kbps. This region contained five RefSeq genes (RB1, P2RY5, FNDC3A, MLNR and CAB39L) on the University of California Santa Cruz website. The RB1 gene was selected as a candidate gene and five SNPs were identified in the gene. The association results indicated that the RB1 gene was a major gene for BW and bone traits. The SNPs g.39692 G>A and g.77260 A>G in RB1 gene might be two quantitative trait nucleotides for BW and bone traits.

show abstract

Genetics of Equine Orthopedic Disease

Metzger¹,

Distl²

2020

Veterinary Clinics of North America: Equine Practice

View full text Add to dashboard Cite

Fine mapping a quantitative trait locus on horse chromosome 2 associated with radiological signs of navicular disease in Hanoverian warmblood horses

Cited by 5 publications

References 9 publications

Changes in Navicular Bone (os sesamoideum distale) Shape in Horses as a Result of Pathological Alterations

Changes in Navicular Bone (os sesamoideum distale) Shape in Horses as a Result of Pathological Alterations

Fine-mapping of quantitative trait loci for body weight and bone traits and positional cloning of the RB1 gene in chicken

Genetics of Equine Orthopedic Disease

Contact Info

Product

Resources

About