Fine Motor Skills of Children With Amblyopia Improve Following Binocular Treatment

Webber, Ann; Wood, Joanne M.; Thompson, Benjamin

doi:10.1167/iovs.16-19797

Cited by 67 publications

(79 citation statements)

References 38 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…These approaches may reactivate latent binocular pathways by reducing inhibitory interactions, boosting attenuated excitatory function, and/or shifting the synaptic modification threshold in favor of potentiation (reviewed in Hess & Thompson, 2015). For example, recent studies have found that both amblyopic preschool children and adults can show enhanced improvements in visual and motor function by playing dichoptic iPad or iPod games (Hess et al, 2011; Birch et al, 2015; Vedamurthy et al, 2015; Webber et al, 2016). Since the lack of binocular function is a key risk factor for persistent amblyopia, the development of new binocular training strategies may have a substantial impact on improving acuity and recovering stereopsis (reviewed in Levi et al, 2015).…”

Section: Environmental and Behavioral Treatmentsmentioning

confidence: 99%

Amblyopia: New molecular/pharmacological and environmental approaches

Stryker

Löwel

2018

Vis Neurosci

View full text Add to dashboard Cite

Emerging technologies are now giving us unprecedented access to manipulate brain circuits, shedding new light on treatments for amblyopia. This research is identifying key circuit elements that control brain plasticity and highlight potential therapeutic targets to promote rewiring in the visual system during and beyond early life. Here, we explore how such recent advancements may guide future pharmacological, genetic, and behavioral approaches to treat amblyopia. We will discuss how animal research, which allows us to probe and tap into the underlying circuit and synaptic mechanisms, should best be used to guide therapeutic strategies. Uncovering cellular and molecular pathways that can be safely targeted to promote recovery may pave the way for effective new amblyopia treatments across the lifespan.

show abstract

Section: Environmental and Behavioral Treatmentsmentioning

confidence: 99%

Amblyopia: New molecular/pharmacological and environmental approaches

Stryker

Löwel

2018

Vis Neurosci

View full text Add to dashboard Cite

show abstract

“…In addition to reporting visual acuity change, recent amblyopia treatment studies, including randomised clinical trials, have sought to quantify changes in the level of suppression or stereoacuity . This requires recording binocular function in individuals with a broad range of measureable stereoacuity through to those with complete suppression and no measurable stereopsis.…”

Section: Introductionmentioning

confidence: 99%

From suppression to stereoacuity: a composite binocular function score for clinical research

Webber

Wood

Thompson

et al. 2019

Ophthalmic Physiologic Optic

Self Cite

View full text Add to dashboard Cite

Purpose: This study aimed to validate a binocular function score that is based on common clinical measures of visual function, providing a more complete analysis of binocular outcomes, against laboratory-based dichoptic tests of threshold stereoacuity and depth of suppression. Methods: Scores on a composite binocular function (BF) score derived from clinical stereoacuity measures (Randot Preschool Stereoacuity Test and Randot Butterfly) and the Worth 4 Dot test were determined in adults (n = 20; age 24.8 ± 7.2 years) and children (N = 77; age 8.3 ± 1.7 years) with abnormal binocular vision from strabismus or amblyopia. Adults had threshold stereoacuity measured with a novel, computerised dichoptic psychophysical test of stereopsis. Depth of suppression (dichoptic eye chart inter-ocular contrast balance test) was determined in both adults and children. Results: Clinical Randot stereoacuity was measurable in 50% of adult and 61% of child participants. Threshold stereoacuity was measurable in 65% of the adult participants. The presence of suppression or simultaneous perception (flat fusion or diplopia) was measurable in all participants, enabling assignment of a BF score to all participants in both groups. In adults, the BF score was highly correlated with the psychophysical threshold stereoacuity measure (ρ = 0.71; p < 0.001). In both adults and children, there was also a high correlation between the BF score and inter-ocular contrast balance (adult ρ = 0.90; child ρ = 0.86; p < 0.001). Conclusions: The composite BF score is a convenient and valid scale of binocularity that can be used to extend the stereoacuity measure in cohorts where nil stereoacuity is common and thus could be considered as an outcome measure in clinical trials.

show abstract

“…Disorders of binocular vision such as amblyopia and strabismus disrupt normal development of visually guided reaching and grasping (Grant, Suttle, Melmoth, Conway, & Sloper, 2014; Simon Grant & Conway, 2014; Simon Grant, Melmoth, Morgan, & Finlay, 2007; Simon Grant & Moseley, 2011b; Mazyn, Lenoir, Montagne, Delaey, & Savelsbergh, 2007; Melmoth, Finlay, Morgan, & Grant, 2009; O’Connor, Birch, Anderson, & Draper, 2010b; Suttle, Melmoth, Finlay, Sloper, & Grant, 2011) and impair performance on standardized tests of fine motor function (Caputo et al, 2007; Drover, Stager, Morale, Leffler, & Birch, 2008; Hrisos, Clarke, Kelly, Henderson, & Wright, 2006; Rogers, Chazan, Fellows, & Tsou, 1982; Webber, Wood, Gole, & Brown, 2008, Webber, Wood, & Thompson, 2016). However, the relationship between stereoacuity and fine motor function in normally developing children may be limited to specific tasks.…”

Section: Introductionmentioning

confidence: 99%

Global motion perception is related to motor function in 4.5-year-old children born at risk of abnormal development

et al. 2017

Self Cite

View full text Add to dashboard Cite

Global motion perception is often used as an index of dorsal visual stream function in neurodevelopmental studies. However, the relationship between global motion perception and visuomotor control, a primary function of the dorsal stream, is unclear. We measured global motion perception (motion coherence threshold; MCT) and performance on standardized measures of motor function in 606 4.5-year-old children born at risk of abnormal neurodevelopment. Visual acuity, stereoacuity and verbal IQ were also assessed. After adjustment for verbal IQ or both visual acuity and stereoacuity, MCT was modestly, but significantly, associated with all components of motor function with the exception of gross motor scores. In a separate analysis, stereoacuity, but not visual acuity, was significantly associated with both gross and fine motor scores. These results indicate that the development of motion perception and stereoacuity are associated with motor function in pre-school children.

show abstract

Fine Motor Skills of Children With Amblyopia Improve Following Binocular Treatment

Abstract: Binocular treatment provided by dichoptic iPod game play improved FMS performance in children with amblyopia, particularly in those with less severe amblyopia. Improvements were maintained at 3 months following cessation of treatment.

Cited by 67 publications

References 38 publications

Amblyopia: New molecular/pharmacological and environmental approaches

Amblyopia: New molecular/pharmacological and environmental approaches

From suppression to stereoacuity: a composite binocular function score for clinical research

Global motion perception is related to motor function in 4.5-year-old children born at risk of abnormal development

Contact Info

Product

Resources

About