Fine Needle Aspiration Biopsy Diagnosis of Renal Masses in Children: A Brief Review

Akhtar, Mohammed; Al‐Dayel, Fouad; Ali, Muhammad

doi:10.5144/0256-4947.1994.45

Cited by 2 publications

(5 citation statements)

References 27 publications

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“…The cytomorphology of renal masses in children was reviewed by Akhtar et al 17 Wilms' tumor is the most common malignant renal neoplasm in children and has a complex morphology mimicking stages of renal embyogenesis. The cytomorphology of renal masses in children was reviewed by Akhtar et al 17 Wilms' tumor is the most common malignant renal neoplasm in children and has a complex morphology mimicking stages of renal embyogenesis.…”

Section: Logistic Regression Analysis Of Srcnmentioning

confidence: 99%

“…While a wide variety of cytologic features have been described as occurring in Wilms' tumors, 11,12,14,[17][18][19][20][21][22] the presence of a bi-or triphasic cell population and the identification of tubules have been cited as most important in the specific diagnosis of Wilms' tumor. While a wide variety of cytologic features have been described as occurring in Wilms' tumors, 11,12,14,[17][18][19][20][21][22] the presence of a bi-or triphasic cell population and the identification of tubules have been cited as most important in the specific diagnosis of Wilms' tumor.…”

Section: Logistic Regression Analysis Of Srcnmentioning

confidence: 99%

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Logistic regression analysis of small round cell neoplasms: A cytologic study

1999

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The diagnosis of small round cell neoplasms (SRCN) Key Words: small round cell neoplasms; FNA; logistic regression analysis Small round cell neoplasms (SRCN) are a group of morphologically similar neoplasms of widely differing histogenesis. These neoplasms are composed of sheets of uniform small round cells which can defy classification by light microscopy even when such examination is supplemented by immunohistochemistry and ultramicroscopy. 1 Differential diagnosis of these malignancies is influenced by the age of the patient, their site of occurrence, and slight degrees of differentiation exemplified by minor architectural and cytoplasmic features. The problem of differential diagnosis is compounded when these neoplasms are examined by cytologic methods, most particularly fine-needle aspiration (FNA) cytology. Numerous case reports and series have described the morphologic findings in small round cell neoplasms of the pediatric age group category, 2-31 but few reports 31, 32 have investigated the diagnostic value of such findings or directly compared the incidence of these cytologic features in the various neoplasms.To better define the differential diagnostic value of the cytomorphologic features described within the literature, we performed a logistic regression analysis of these features for the diagnosis of the more common SRCN, exclusive of small-cell carcinoma. Herein we report the results of that study. Materials and MethodsThe files of the Department of Pathology at Duke University and the consultation files of one of the authors (L.J.L.) were searched for all small round cell neoplasms exclusive of small-cell carcinoma but including Ewing's sarcoma, peripheral neuroectodermal tumor, nephroblastoma (Wilms' tumor), neuroblastoma, lymphoma, rhabdoid tumor, rhabdomyosarcoma, and hepatoblastoma. Sixty-two cases were identified and were distributed as follows: Ewing's sarcoma (19 cases), rhabdomyosarcoma (6 cases), neuroblastoma (10 cases), nephroblastoma (14 cases), lymphoma (10 cases), and hepatoblastoma (3 cases). The three cases of hepatoblastoma were not analyzed in the present study. The remaining cases were analyzed for the 28 variables shown in Table I. An additional four variables comprising disassociated cells, central nuclei, cytoplasmic inclusions, and tangles were not analyzed. Disassociated cells and central nuclei were not included in the analysis because only two and three cases, respectively, were negative for these findings. Cytoplasmic inclusions and tangles were not analyzed because only one

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Section: Logistic Regression Analysis Of Srcnmentioning

confidence: 99%

Section: Logistic Regression Analysis Of Srcnmentioning

confidence: 99%

Logistic regression analysis of small round cell neoplasms: A cytologic study

1999

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“…FNA represents one such technique which has received considerable notoriety in the past decade. 6,[9][10][11]17,[22][23][24]31 The success of advanced chemotherapeutic protocols is based on definitive cell typing in order to select the most appropriate and specific combination of chemotherapeutic agents possible. The specific diagnosis of these neoplasms can be difficult even when optimally fixed and processed histologic material is available.…”

Section: Discussionmentioning

confidence: 99%

“…While not traditionally considered a small round cell malignancy of childhood, Wilms' tumor frequently displays a small round cell morphology in cytologic preparations. The cytomorphology of renal masses in children was reviewed by Akhtar et al 17 Wilms' tumor is the most common malignant renal neoplasm in children and has a complex morphology mimicking stages of renal embyogenesis. 43 Wilms' tumors contain variable mixtures of three morphologic components, including blastemal, epithelial, and stromal elements.…”

Section: Logistic Regression Analysis Of Srcnmentioning

confidence: 99%

“…It is these latter components which allow distinction of Wilms' tumors from other SRCN of childhood. While a wide variety of cytologic features have been described as occurring in Wilms' tumors, 11,12,14,[17][18][19][20][21][22] the presence of a bi-or triphasic cell population and the identification of tubules have been cited as most important in the specific diagnosis of Wilms' tumor. 11,18,20,21 Our findings support these statements in that the positive expression of tubules was highly associated with a diagnosis of Wilms' tumor (P Ͻ 0.001).…”

Section: Logistic Regression Analysis Of Srcnmentioning

confidence: 99%

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Logistic regression analysis of small round cell neoplasms: A cytologic study

1999

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The diagnosis of small round cell neoplasms (SRCN) in children is difficult by both histologic and cytologic methods. These neoplasms are unified morphologically by the scanty cytoplasm surrounding relatively round nuclei containing a primitive chromatin pattern. Further categorization is achieved histologically by the recognition of architectural differentiation and cytoplasmic features. Numerous series and case reports documenting the cytologic features of SRCN have been published in the English‐language literature, but relatively few studies have statistically analyzed the diagnostic utility of these features. Our logistic regression analysis of 59 cases of SRCN indicates that the presence of an extremely scanty cytoplasm favors the diagnosis of Ewing's sarcoma (P = 0.004), as does the positive expression of cytoplasmic vacuoles (P = 0.02). Strap or tadpole cells closely correlate with the diagnosisof rhabdomyosarcoma (P < 0.001). The positive expression of rosettes strongly supports the presence of a neuroblastoma (P < 0.001). The diagnosis of Wilms' tumor is confirmed by the expression of tubules (P < 0.001). The presence of lymphoglandular bodies strongly favors the diagnosis of lymphoma (P < 0.001). While some cytologic features are highly correlated with specific SRCN, these features are not invariably present, and definitive diagnosis may require immunohistochemical or ultrastructural analysis performed on cell block material. Diagn. Cytopathol. 1999;20:271–277. © 1999 Wiley‐Liss, Inc.

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Fine Needle Aspiration Biopsy Diagnosis of Renal Masses in Children: A Brief Review

Cited by 2 publications

References 27 publications

Logistic regression analysis of small round cell neoplasms: A cytologic study

Logistic regression analysis of small round cell neoplasms: A cytologic study

Logistic regression analysis of small round cell neoplasms: A cytologic study

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