Fine needle aspiration biopsy: diagnostic utility in resource-limited settings

Abstract

FNAB provides a definitive tissue diagnosis in the majority of patients. Well-trained nurse aspirators perform as well as pathologists, indicating the feasibility of FNAB in resource-limited settings.

Endemic Burkitt lymphoma: a 28-day treatment schedule with cyclophosphamide and intrathecal methotrexate

“…The diagnosis was confirmed on initial FNA in 73% of patients, which confirms the value and place of FNA in resource-limited settings. 16 The fact that 50% of patients were below the 5th centile for weight/height (weight included the tumour mass), and the presence of anaemia, malaria, intestinal parasites and urinary bilharziasis in a significant number of patients, emphasises the need to recognise and manage the co-morbidities in this patient population. 17 The risk of relapse is ,5% after 1 year, and the 1-year event-free survival rate is thus a reasonable index of cure in eBL.…”

Assessment of children exposed to adult pulmonary tuberculosis in Cali, Colombia

“…19 Fine-needle aspiration biopsy, a specimen-collection procedure with a high bacteriological yield for confirming M. tuberculosis, does not necessarily require a physician, surgeon or pathologist to undertake it and it has been demonstrated that in resourcelimited settings it can be competently performed by well trained nurses. 20,21 In low-and middle-income countries, it has been demonstrated that screening and treating TB infection during contact-tracing is a highly cost-effective intervention. 22 Tools such as DMA can be used for active and passive case-finding and can also facilitate identification of the onset of clinical and radiological manifestations, which represents the breakpoint between self-contained infection and TB in children.…”

Screening for Residual Disease in Pediatric Burkitt Lymphoma Using Consensus Primer Pools

“…However, as a clinical tool, identifying patient-specific primers (PSP) designed from primary diagnostic tissue is labor-intensive and may not be applicable for real-time applications [7]. When faced with limited amount of tissue at the time of diagnosis, particularly from children, there may not be enough tissue available to design PSP if PD/MRD studies are to be tested [10-12]. The current study hypothesizes that detection of PD/MRD in BL cases may be accomplished by more efficient means and not require primary diagnostic tissue to design unique PSP.…”