Fine-needle aspiration biopsy for the diagnosis of bone and soft tissue lesions: a systematic review and meta-analysis

Chambers, Meagan; O’Hern, Keegan; Kerr, Darcy A.

doi:10.1016/j.jasc.2020.05.012

Cited by 30 publications

(28 citation statements)

References 45 publications

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“…When diagnostic yield is defined as the number of cases given a diagnosis over the total number of cases, 36 FNA was found to have a diagnostic yield of 52.5%. 45 In our study of 171 cases, the diagnostic yield for CNB was 96.5% (165/171). Even if the 11 false-negative cases (where only benign striated muscle and fibroadipose tissue were found) were considered non-diagnostic, the diagnostic yield for CNB would have been 90%.…”

Section: Discussionmentioning

confidence: 59%

“…This degree of accuracy is statistically the same as that reported by Birgin, et al 19 for CNB with a 97% sensitivity and 99% specificity. Accuracy for the prediction of histologic sub-type of malignancies was also found to be highly accurate by Chambers et al 45 They found that FNA accurately predicted the sub-type of malignancy in 87.0% of cases. This compares favorably with the accuracy of CNB biopsy in specific sub-typing of soft tissue neoplasms.…”

Section: Discussionmentioning

confidence: 76%

“…Many studies have compared the diagnostic accuracy of fine-needle aspiration with CNB, CNB with incisional biopsy and FNA with both CNB and final diagnosis at the time of resection. [2][3][4][5][35][36][37][38][39][40][41][42][43][44][45] Results…”

Section: Discussionmentioning

confidence: 99%

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Core needle biopsy for the diagnosis of primary soft tissue lesions: Accuracy and diagnostic challenges

Layfield

Stegelmeier

Wang

et al. 2022

Diagnostic Cytopathology

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Background: Core needle biopsy (CNB) and fine needle aspiration (FNA) are currently the most common biopsy methods for investigation of soft tissue lesions. Selection of the method to be used depends on a number of factors including diagnostic accuracy, local expertise with the techniques and the need for ancillary testing. We investigated the diagnostic accuracy of CNB and factors influencing the selection of CNB or FNA.Methods: An electronic search of the surgical pathology records for all core needle biopsies of soft tissue lesions with subsequent incisional biopsies or excisions between January 1, 2015 and December 31, 2021 was performed. Searches of the literature for publications documenting diagnostic accuracy of core biopsy and FNA were performed using the Pub Med literature data base. Results:The electronic search yielded 177 CNBs with appropriate follow-up. Six cases were non-diagnostic. The remaining 171 cases showed an accuracy of 90% for separation of benign from malignant with two false-positive and 17 false-negative diagnoses. The literature search revealed 11 series of CNBs with a diagnostic accuracy of 74% to 97%. The literature search revealed 20 series of FNAs with an accuracy of 84.8% to 100% for separation of benign from malignant.Conclusions: Core needle biopsy is a highly accurate diagnostic technique with an accuracy of 90% for separation of benign from malignant lesions. The percentage of non-diagnostic cases is low (3.4%). No significant biopsy related complications were seen in this study.

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Section: Discussionmentioning

confidence: 59%

Section: Discussionmentioning

confidence: 76%

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Core needle biopsy for the diagnosis of primary soft tissue lesions: Accuracy and diagnostic challenges

Layfield

Stegelmeier

Wang

et al. 2022

Diagnostic Cytopathology

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“…In solchen Fällen kann häufig auf eine Knochenstanze verzichtet und auf die schonenderen Truecutoder Feinnadeln zurückgegriffen werden [159]. Sensitivität und Spezifität bei Einsatz von Feinnadeln sind vergleichbar mit Hohlnadelpunktionen und offenen Probenentnahmen [160]. Am häufigsten wird die Indikation zur Materialgewinnung an Wirbelsäule/ Sakrum gestellt.…”

Section: Knöcherne Prozesseunclassified

Alternativen histologischer Materialgewinnung – Wann und wie ist die histologische Sicherung mittels Ultraschall (US), Computertomografie (CT) oder Endosonografie (EUS) sinnvoll?

Möller

Dietrich²,

Faiss

et al. 2021

Z Gastroenterol

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ZusammenfassungDie histologische Sicherung von Tumoren ist zusammen mit einem adäquaten Staging die Voraussetzung für eine stadiengerechte und personalisierte Therapie. Beschrieben werden Indikationen, technische Möglichkeiten und Einschränkungen sowie potenzielle Komplikationen der bildgebend geführten Nadelbiopsie mittels Ultraschalls (US), Computertomografie (CT) und Endosonografie (EUS). Welches Verfahren für welches Organ und welche Läsion?

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“…Due to its success, FNAB is developed to be the initial method to preoperative diagnosis of all tumors, both benign and malignant. FNAB has several advantages due to its simple and less invasive nature, well tolerated by patients, minimal risk of complication, ability to yield quicker results, and low cost [2], [3], [4], [5]. FNAB can also sample more easily multiple areas of a mass, potentially providing more representative material than one or two core needle biopsy specimens [3].…”

Section: Introductionmentioning

confidence: 99%

Cutoff Value of the Numbers of Anaplastic Cytological Features Present in Fine-Needle Aspiration Biopsy of Bone Tumors to Predict Malignancy

Norahmawati

Rahmadiani

Rakhmani

et al. 2022

Open Access Maced J Med Sci

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Bone neoplasms are rarely found; however, they usually occur in young patients. It is imperative to diagnose these conditions promptly and accurately, as patient’s outcomes also depend on timely and appropriate treatments. Fine Needle Aspiration Biopsy (FNAB) is increasingly utilized as a method of establishing preoperative diagnosis of bone tumors because it is less invasive, rapid, and cost-effective. This study aims to determine the diagnostic value of the presence of certain cytological features in FNAB for bone tumors, evaluate cytological features to differentiate between benign and malignant bone tumors, and determine the cut-off point of the presence of certain cytological features of FNAB in bone tumors. This study is an analytical cross-sectional study to 35 bone tumor cases which underwent FNAB and subsequent histopathological examination from January 2014 – December 2017 in the Department of Anatomic Pathology of Saiful Anwar General Hospital. Diagnostic value testing was performed using 2x2 table and Receiver Operating Characteristic (ROC) curve to determine the sensitivity, specificity, and accuracy of FNAB by evaluating cytological features of anaplasia in differentiating between benign and malignant bone tumors in comparation to histopathological examination. The result revealed that the presence of >4 cytological features of anaplasia without the presence of clinicoradiological data yield 81.82% sensitivity, 100% specificity, 100% positive predictive value, 76.47% negative predictive value, and 88.57% accuracy. In conclusion, cytological features of anaplasia could become a reliable predictor in determining benignity and malignancy of bone tumors especially in cases where clinicoradiological data are insufficient.

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Fine-needle aspiration biopsy for the diagnosis of bone and soft tissue lesions: a systematic review and meta-analysis

Cited by 30 publications

References 45 publications

Core needle biopsy for the diagnosis of primary soft tissue lesions: Accuracy and diagnostic challenges

Core needle biopsy for the diagnosis of primary soft tissue lesions: Accuracy and diagnostic challenges

Alternativen histologischer Materialgewinnung – Wann und wie ist die histologische Sicherung mittels Ultraschall (US), Computertomografie (CT) oder Endosonografie (EUS) sinnvoll?

Cutoff Value of the Numbers of Anaplastic Cytological Features Present in Fine-Needle Aspiration Biopsy of Bone Tumors to Predict Malignancy

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