Fine‐needle aspiration biopsy in children: Experience in 70 cases

Verdeguer, Amparo; Castel, Victoria; Torres, V.; Olagüe, R.; Ferrís, J; Esquembre, Carlos; Vallcanera, A.; Muro, Masahiko

doi:10.1002/mpo.2950160206

Cited by 25 publications

(12 citation statements)

References 10 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…When required, both FNA and CNB techniques provide adequate samples. The cellularity was judged satisfactory in 82% to 85% of our cases, in agreement with the literature (i.e., 76% to 93% for FNA and 80% to 95% for CNB) . However, our data confirm a significantly higher diagnostic accuracy of CNB, as previously reported .…”

Section: Discussionsupporting

confidence: 92%

“…The cellularity was judged satisfactory in 82% to 85% of our cases, in agreement with the literature (i.e., 76% to 93% for FNA and 80% to 95% for CNB). [13][14][15]17,[45][46][47][48][49][50][51] However, our data confirm a significantly higher diagnostic accuracy of CNB, as previously reported. 13,[15][16][17][18]52,53 Nevertheless, in our experience, FNA remains useful in several settings: it allows extemporaneous examinations during the procedure, helping physicians performing biopsies to adjust the amount of tissue to be obtained.…”

Section: However the Relevant Tumor Volume Threshold Below Which A Bsupporting

confidence: 92%

See 1 more Smart Citation

Indications and results of diagnostic biopsy in pediatric renal tumors: A retrospective analysis of 317 patients with critical review of SIOP guidelines

Monneraye

Michon

Pacquement

et al. 2019

Pediatric Blood & Cancer

View full text Add to dashboard Cite

Objectives According to the Renal Tumor Study Group (RTSG) of the International Society of Paediatric Oncology (SIOP), diagnostic biopsy of renal tumors prior to neoadjuvant chemotherapy is not mandatory unless the presentation is atypical for a Wilms tumor (WT). This study addresses the relevance of this strategy as well as the accuracy and safety of image‐guided needle biopsy. Methods Clinical, radiological, and pathological data from 317 children (141 males/176 females, mean age: 4 years, range, 0–17.6) consecutively treated in one SIOP‐affiliated institution were retrospectively analyzed. Results Presumptive chemotherapy for WT was decided for 182 patients (57% of the cohort), 24 (8%) were operated upfront, and 111 (35%) were biopsied at diagnosis. A non‐WT was confirmed after surgery in 5/182 (3%), 11/24 (46%), and 28/111 (25%), respectively. Age at diagnosis was the most commonly (46%) used criterion to go for biopsy but a nine‐year threshold should be retrospectively considered more relevant. Tumor volumes of clear cell sarcoma of the kidney and WT were significantly higher than those of other tumors (P = 0.002). The agreement between core‐needle biopsy (CNB) and final histology was 99%. No significant morbidity was associated with CNB. Conclusion The use of SIOP criteria to identify patients eligible for presumptive WT neoadjuvant chemotherapy or upfront surgery avoided biopsy in 65% of children and led to a 97% rate of appropriate preoperative chemotherapy. Image‐guided CNB is a safe and accurate diagnostic procedure. The relevance of SIOP biopsy criteria might be improved by using an older age threshold (9 years instead of 6 years) and by adding initial tumor volume.

show abstract

Section: Discussionsupporting

confidence: 92%

Section: However the Relevant Tumor Volume Threshold Below Which A Bsupporting

confidence: 92%

Indications and results of diagnostic biopsy in pediatric renal tumors: A retrospective analysis of 317 patients with critical review of SIOP guidelines

Monneraye

Michon

Pacquement

et al. 2019

Pediatric Blood & Cancer

View full text Add to dashboard Cite

show abstract

“…FNAC for histological confi rmation prior to chemotherapy was allowed in the 2001-SIOP Wilms tumor protocol, with no risk of upstaging [14]. Different studies have been reported regarding the effectiveness of FNAC in the diagnosis of renal tumors in children [15][16][17]. However, some investigators consider FNAC as a sub-optimal diagnostic tool, with a high rate of false positives and negatives [18].…”

Section: Discussionmentioning

confidence: 97%

Fine-needle aspiration cytopathology in the diagnosis of Wilms tumor

et al. 2011

View full text Add to dashboard Cite

BACKGROUND/PURPOSE The International Society of Paediatric Oncology (SIOP) protocol for Wilms tumor (WT) includes preoperative chemotherapy as the initial approach. However, an inadequate treatment may be performed in case of histological misdiagnosis. We evaluated the impact of fine-needle aspiration cytopathology (FNAC) in the diagnosis of unilateral WT in our group of patients. MATERIALS AND METHODS A retrospective descriptive study of patients with diagnosis of unilateral WT who underwent FNAC prior to neoadjuvant chemotherapy between 1993 and 2009 was performed. We reviewed the cytological diagnosis obtained by ultrasound-guided FNAC and the histological correlation with the resected specimens. RESULTS FNAC was performed in 66 patients with unilateral WT. In 57 of the 58 patients with positive FNAC for WT, the final diagnosis was correct (PPV: 98.2%). In 8 cases with negative FNAC for WT, the final diagnosis was positive for WT in 3 patients (NPV: 62.5%). Sensitivity was 95% and specificity was 83.3%. No complications were found associated with the procedure, except for an episode of haematuria, which resolved spontaneously. CONCLUSIONS FNAC is a useful and feasible technique in children that may confirm the suspected diagnosis of unilateral WT, avoiding inadequate preoperative chemotherapy in case of a non-Wilms renal tumor.

show abstract

“…For these reasons, in the UKCCSG WT Study 3 pre-chemotherapy histologic diagnosis obtained by biopsy was required. Although some advocate percutaneous FNA as a reliable means of recognising histologic features of renal tumors of childhood [10], other studies have shown to be a suboptimal method with both false-positive and false-negative results [11].…”

Section: Discussionmentioning

confidence: 99%

The role of biopsy in the diagnosis of renal tumors of childhood: Results of the UKCCSG Wilms tumor study 3

Vujanić

Kelsey

Mitchell

et al. 2002

Med. Pediatr. Oncol.

140

View full text Add to dashboard Cite

Background The United Kingdom Children's Cancer Study Group (UKCCSG) Wilms Tumor Study 3 has adopted preoperative chemotherapy for Wilms tumors (WT), but required prechemotherapy biopsy for histologic diagnosis. The aims of this review were to assess the usefulness and safety of prechemotherapy biopsy and to compare histologic features of WT before and after chemotherapy. Procedure There were 286 eligible patients but only 241 biopsies and 226 nephrectomy case slides were submitted for panel review. The presence of different histologic components of WT before and after chemo therapy was retrospectively assessed. Results Among the 241 cases, the biopsy material in 9 (4%) was not diagnostic, in 28 (12%) that were clinically and radiologically consistent with WT, the biopsy revealed tumors other than WT, and in the remaining 204 (85%) WT was confirmed. Of 188 WT suitable cases, blastema was found in 89% of tumors at biopsy, but in only 50% at nephrectomy; the remainder were either completely necrotic (17%) or showed only epithelial and/or stromal elements (33%). Of 182 children who had percutaneous cutting needle biopsy (PCNB), a fall in haemoglobin (20% of cases) and local pain (19%) were the most common complications. One child re quired emergency nephrectomy due to massive intratumoral bleeding, another had tumor rupture and subsequently died, and a third developed a needle track recurrence 8 months after the biopsy. Conclusions A number of renal tumors (12%) can have the correct histologic diagnosis made by PCNB. Preoperative chemo therapy markedly decrease in the number of samples with preserved blastema. The morbidity associated with PCNB is small. Needle biopsy of any renal mass prior to initiation of chemotherapy is recommended. Med Pediatr Oncol 2003;40:18–22, © 2003 Wiley‐Liss, Inc.

show abstract

Fine‐needle aspiration biopsy in children: Experience in 70 cases

Cited by 25 publications

References 10 publications

Indications and results of diagnostic biopsy in pediatric renal tumors: A retrospective analysis of 317 patients with critical review of SIOP guidelines

Indications and results of diagnostic biopsy in pediatric renal tumors: A retrospective analysis of 317 patients with critical review of SIOP guidelines

Fine-needle aspiration cytopathology in the diagnosis of Wilms tumor

The role of biopsy in the diagnosis of renal tumors of childhood: Results of the UKCCSG Wilms tumor study 3

Contact Info

Product

Resources

About