Fine‐needle aspiration biopsy of abdominal and retroperitoneal tumors in infants and children

Valkov, Ivan; Bojikin, Boris

doi:10.1002/dc.2840030208

Cited by 17 publications

(8 citation statements)

References 6 publications

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“…Glomeruluslike structures were present in two cases in this study. Similar structures have been reported by Valkov et al 36 in one of their three cases.…”

Section: Discussionsupporting

confidence: 91%

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Small Round Cell Tumors of the Abdomen and Thorax

Das

Bhambhani²,

Chachra³

et al. 1997

Acta Cytologica

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“…Glomeruluslike structures were present in two cases in this study. Similar structures have been reported by Valkov et al 36 in one of their three cases.…”

Section: Discussionsupporting

confidence: 91%

“…12,23,31,36 In the present study, the frequency of SRCT was also very high among intrathoracic and intraabdominal childhood malignancies (78.1%). This was significantly higher compared to the frequency of these tumors (13.2%) among adult malignancies (P < .001).…”

Section: Discussionmentioning

confidence: 76%

Small Round Cell Tumors of the Abdomen and Thorax

Das

Bhambhani²,

Chachra³

et al. 1997

Acta Cytologica

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“…35,36 These therapeutic advances have encouraged the development and utilization of minimally invasive diagnostic test techniques for pediatric patients. 37,38 Multiple cytomorphologic descriptions for the major SRCN of childhood have been reported in the literature, but fewer reports have demonstrated the diagnostic utility of these features in separating the various small round cell malignancies of childhood. 6,[9][10][11]17,[22][23][24]31 The success of advanced chemotherapeutic protocols is based on definitive cell typing in order to select the most appropriate and specific combination of chemotherapeutic agents possible.…”

Section: Discussionmentioning

confidence: 99%

“…13,16,22,24,25,31,32,37,38 Akhtar et al 13 reported that individual cells with long cytoplasmic processes, fibrillary tangles, and pseudorosettes were characteristic of neuroblastoma. 13,16,22,24,25,31,32,37,38 Akhtar et al 13 reported that individual cells with long cytoplasmic processes, fibrillary tangles, and pseudorosettes were characteristic of neuroblastoma.…”

Section: Logistic Regression Analysis Of Srcnmentioning

confidence: 99%

Logistic regression analysis of small round cell neoplasms: A cytologic study

1999

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The diagnosis of small round cell neoplasms (SRCN) Key Words: small round cell neoplasms; FNA; logistic regression analysis Small round cell neoplasms (SRCN) are a group of morphologically similar neoplasms of widely differing histogenesis. These neoplasms are composed of sheets of uniform small round cells which can defy classification by light microscopy even when such examination is supplemented by immunohistochemistry and ultramicroscopy. 1 Differential diagnosis of these malignancies is influenced by the age of the patient, their site of occurrence, and slight degrees of differentiation exemplified by minor architectural and cytoplasmic features. The problem of differential diagnosis is compounded when these neoplasms are examined by cytologic methods, most particularly fine-needle aspiration (FNA) cytology. Numerous case reports and series have described the morphologic findings in small round cell neoplasms of the pediatric age group category, 2-31 but few reports 31, 32 have investigated the diagnostic value of such findings or directly compared the incidence of these cytologic features in the various neoplasms.To better define the differential diagnostic value of the cytomorphologic features described within the literature, we performed a logistic regression analysis of these features for the diagnosis of the more common SRCN, exclusive of small-cell carcinoma. Herein we report the results of that study. Materials and MethodsThe files of the Department of Pathology at Duke University and the consultation files of one of the authors (L.J.L.) were searched for all small round cell neoplasms exclusive of small-cell carcinoma but including Ewing's sarcoma, peripheral neuroectodermal tumor, nephroblastoma (Wilms' tumor), neuroblastoma, lymphoma, rhabdoid tumor, rhabdomyosarcoma, and hepatoblastoma. Sixty-two cases were identified and were distributed as follows: Ewing's sarcoma (19 cases), rhabdomyosarcoma (6 cases), neuroblastoma (10 cases), nephroblastoma (14 cases), lymphoma (10 cases), and hepatoblastoma (3 cases). The three cases of hepatoblastoma were not analyzed in the present study. The remaining cases were analyzed for the 28 variables shown in Table I. An additional four variables comprising disassociated cells, central nuclei, cytoplasmic inclusions, and tangles were not analyzed. Disassociated cells and central nuclei were not included in the analysis because only two and three cases, respectively, were negative for these findings. Cytoplasmic inclusions and tangles were not analyzed because only one

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“…The FNAC features of neuroblastic tumors have been amply described either as exclusive studies [9][10][11] or as a part of studies on pediatric malignancies or small round cell tumors. [12][13][14][15] The frequency of rosettes in FNA smears of neuroblastomas varies from 18.8% to 71.9%, with an average of 45.9% 9,10,13,15,16 Rosettes or rosettelike structures can be observed in nephroblastoma 15 and Ewing's sarcoma in rare cases. 17 Filamentous or fibrillary background material is also an important morphologic feature of neuroblastoma, observed in < 50-100% of cases, 9,10,13,15,16 but has not been observed in other small round cell tumors that are considered in the differential diagnosis of neuroblastoma.…”

Section: Discussionmentioning

confidence: 99%