Fine-needle aspiration biopsy of chromophobe renal cell carcinoma and oncocytoma

Wiatrowska, Beata A.; Zakowski, Maureen F.

doi:10.1002/(sici)1097-0142(19990625)87:3<161::aid-cncr10>3.0.co;2-i

Cited by 52 publications

(36 citation statements)

References 15 publications

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“…[12][13][14][15][16] Diffuse cytoplasmic positivity for HCI is a hallmark for this tumor and distinguishes it from RO. 17,18 However, the diagnosis for eosinophilic variant of CRCC is difficult using only conventional stained smears.…”

Section: Discussionmentioning

confidence: 90%

Can renal oncocytomas be distinguished from renal cell carcinoma on fine-needle aspiration specimens?

Liu

Fanning

2001

Cancer

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Section: Discussionmentioning

confidence: 90%

Can renal oncocytomas be distinguished from renal cell carcinoma on fine-needle aspiration specimens?

Liu

Fanning

2001

Cancer

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“…13,14 Numerous articles focusing on various aspects of renal FNA have been published over the last 2 decades. [1][2][3][4][5][6][15][16][17][18][19][20][21][22][23][24][25] At this hospital we are currently experiencing a steady fall in requests for renal FNAs, probably as a direct consequence of the increasing accuracy of imaging techniques. This trend has led us to study whether renal FNA has been totally superseded by modern imaging techniques, or whether FNA can still provide useful additional information to assist urologists in deciding on the appropriate surgical course, and, if so, in which specific clinicopathological situations.…”

Section: Discussionmentioning

confidence: 99%

Solid renal masses in adults: Image‐guided fine‐needle aspiration cytology and imaging techniques—“Two Heads Better Than One?”

García‐Solano

Acosta-Ortega

Pérez-Guillermo

et al. 2007

Diagnostic Cytopathology

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We have compared the diagnostic accuracy of image-guided 25G-FNA (fine-needle aspiration) and imaging modalities in a group of 31 patients with solid space-occupying renal lesions. All patients had undergone total nephrectomy and histologic sections were available for review.By FNA there were 24 malignant diagnoses, I benign diagnosis, and 6 cases with yield inadequate for diagnosis. The FNA accuracy for malignancy was 100% with no false positive cases; cancer typing by FNA matched the final histologic diagnoses in 91.6% of cases. Sensitivity, specificity, positive predictive value, and negative predictive value were 80%, 14%, 80%, and 14%, respectively.Radiologically there were 26 diagnoses of malignancy, I of benignity, and 4 indeterminate lesions (IL). Accuracy for malignancy was 100%, with one false positive case; cancer typing matched the final histologic diagnoses in 84%. Sensitivity of imaging modalities was 86%, specificity 17%, positive predictive value 83%, and negative predictive value 20%. Four IL corresponded to renal cell carcinoma in the final histologic report: two IL had a previous diagnosis of malignancy by FNA, and the yield of two was inadequate for cytologic diagnosis.Both techniques have 100% accuracy for the diagnosis of malignancy. The sensitivity, specificity, positive predictive value, and negative predictive value of imaging techniques are slightly higher than those obtained by FNA. Imaging techniques and FNA of solid renal masses complement each other in IL and in nondiagnostic FNAs. Diagn. Cytopathol. 2008;36:8-12.' 2007 Wiley-Liss, Inc.Key Words: solid renal masses; fine-needle aspiration; needle biopsy; cytology; imaging techniques Fine-needle aspiration (FNA) has a well-defined and traditional role in the diagnosis and treatment of numerous conditions in almost every organ of the body. Its utility is undeniable in space-occupying lesions of various locations; however, the use of FNA in space-occupying lesions of the kidney has recently tended to be confined to specific clinico-pathological conditions, mainly because of the refinement of imaging techniques. [1][2][3][4][5][6] The purpose of this article is 3-fold: to assess the diagnostic accuracy of image-guided 25G-FNA and imaging modalities in a group of 31 patients with solid space-occupying renal lesions who later underwent total nephrectomy (TN) for histologic confirmation; to compare the diagnostic accuracy of the two techniques; and to investigate whether FNA provides valuable information for the clinical management of patients with solid renal masses. Material and MethodsBetween January 2000 and July 2006 a total number of 129 patients of our hospital had been referred to either image-guided 25G-FNA as preoperative diagnostic procedure of renal space-occupying lesions, or to some type of imaging modality for planning clinical management, or had been referred to both. Of these 129 patients, the 31 in whom image-guided FNA, imaging studies, and TN were available were chosen for the present study.The cytologic specimens of im...

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“…La experiencia citoló-gica empieza a ser muy amplia y refleja, en muchos casos, la posibilidad de un diagnóstico específico 1,2,[25][26][27][28][29] . Citológicamente, el oncocitoma se dispone en forma de grupos monoplano y célu-las sueltas de tamaño intermedio a grande con característico citoplasma amplio, de límites bien definidos, densamente teñido y de aspecto finamente granular.…”

Section: Oncocitomaunclassified

“…La inmunoexpresión de citoqueratinas, vimentina, así como la detección de hierro coloidal ha demostrado su utilidad en material de citología. Dos estudios citológicos relevantes han descrito que la diferenciación entre oncocitoma y carcinoma cromófobo es posible en la mayoría de los casos 28,29 . Resulta imprescindible comunicar al patólogo datos clínicos y de imagen ya que pueden ser tan determinantes como la propia imagen citológica.…”

Section: Oncocitomaunclassified

“…Si una neoplasia se encuentra en el límite de tamaño, el diagnóstico de oncocitoma apoyará la decisión de nefrectomía parcial mientras que el de carcinoma favorecerá la realización de nefrectomía radical. Este problema queda reflejado en la literatura citológica, que se muestra optimista en cuanto al reconocimiento especí-fico del carcinoma cromófobo, aunque las publicaciones centradas en el carcinoma cromófobo son todavía escasas 28,29,[40][41][42] . En nuestra experiencia con siete casos el carcinoma cromófobo muestra una celularidad más pleomórfica y citoplasma más heterogéneo que el del oncocitoma así como frecuente binucleación y halos perinucleares (Fig.…”

Section: Carcinoma De Células Renales Tipo Cromófobounclassified

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Utilidad de la citología en el diagnóstico y manejo de tumores renales y perirrenales del adulto

et al. 2007

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RESUMEN UTILIDAD DE LA CITOLOGIA EN EL DIAGNÓSTICO Y MANEJO DE TUMORES RENALES Y PERIRRENALESDEL ADULTO Introducción: El uso cada vez mas extendido de tumorectomías, nefrectomías parciales y tratamientos no quirúrgi-cos de tumores renales ha supuesto un renovado interés en el uso diagnóstico de la citología. Ya sea de forma preoperatoria, a través de la punción aspiración con aguja fina (PAAF), o durante el análisis intraoperatorio, la citología ofrece la posibilidad de un diagnóstico morfológico específico. En esta revisión se actualiza la información concerniente al valor diagnóstico de la citología de tumores renales.Material y métodos: Se ha revisado la bibliografía relativa a las descripciones citológicas de masas renales. Para ello se ha procedido tanto a búsqueda computerizada en la base de datos Medline, como a búsqueda bibliográfica manual. Del mismo modo se incluye la experiencia de los autores tanto en la PAAF de estas lesiones como en el uso intraoperatorio de la citología.Resultados: Entre las neoplasias con presentación citológica más característica destacan el carcinoma renal de células claras y el carcinoma renal papilar. El carcinoma cromófobo y el oncocitoma renal pueden mostrar similitudes, si bien la experiencia acumulada en los últimos años refleja que su diferenciación es posible en la mayoría de los casos. Para el diagnóstico de angiomiolipoma, carcinoma urotelial y metástasis en riñón, la información clínica y de imagen resulta es de gran interés para el patólogo. La integración de dichos datos suele permitir un diagnóstico específico.Conclusión: En general, la citología refleja con fidelidad las características histológicas de las neoplasias renales, permitiendo en muchos casos un diagnóstico específico. Ante la cada vez más frecuente situación de "incidentaloma" renal, consideramos muy apropiado el uso diagnóstico de la citología. La naturaleza mínimamente invasiva de la PAAF y la posibilidad de realización de análisis citológico rápido durante estudios intraoperatorios ofrecen importante información para el manejo terapéutico de estos pacientes.Palabras clave: Riñón. Neoplasia renal. Citología. PAAF. ABSTRACT USEFULNESS OF CYTOLOGY IN DIAGNOSIS AND MANAGEMENT OF RENAL AND PERIRENAL TUMORS IN ADULTSIntroduction: The use more and more extended of tumorectomy, partial nephrectomy and nonsurgical treatments of renal tumors has supposed a renewed interest in the diagnosis use of cytology. Whether during preoperative period, through the puncture aspiration with fine needle (PAAF), or during the intraoperative analysis, the cytology offers the possibility of a specific morphologic diagnosis. In this revision the information concerning the diagnostic value of the cytology in renal tumors is updated.Material and methods: The references related to renal masses cytological descriptions has been reviewed. For this purpose we have searched both with computer in Medline data base and also manually. In the same way we include authors experience as much in the PAAF of these lesions as in the intraoper...

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Fine-needle aspiration biopsy of chromophobe renal cell carcinoma and oncocytoma

Cited by 52 publications

References 15 publications

Can renal oncocytomas be distinguished from renal cell carcinoma on fine-needle aspiration specimens?

Can renal oncocytomas be distinguished from renal cell carcinoma on fine-needle aspiration specimens?

Solid renal masses in adults: Image‐guided fine‐needle aspiration cytology and imaging techniques—“Two Heads Better Than One?”

Utilidad de la citología en el diagnóstico y manejo de tumores renales y perirrenales del adulto

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