2002
DOI: 10.1530/eje.0.1460019
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Fine-needle aspiration biopsy of the thyroid in an area of endemic goitre: influence of restored sufficient iodine supplementation on the clinical significance of cytological results

Abstract: Objective: The iodine status of the population of Poland has markedly improved over the past years. The aims of this paper were: (i) to examine the diagnostic value of fine-needle aspiration biopsy (FNAB) of the thyroid in goitre endemic regions (in conditions of improved iodine supply), and (ii) to find whether the changes in iodine supply have already influenced the clinical interpretation of cytological results. Methods: Cytological diagnoses, based on 3782 aspirates, obtained from 3572 patients during the … Show more

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Cited by 40 publications
(30 citation statements)
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“…The diagnostic value of FNAB (with the exclusion of non-diagnostic outcomes) was assessed in terms of sensitivity, specificity, positive and negative predictive values. In the specific epidemiological situation in Poland, with relatively recent iodine prophylaxis, the risk of cancer -if follicular neoplasm has been discovered with FNAB -is lower than in the case of other suspected lesions (16). Thus, three different definitions of false positive (FP) diagnosis were applied: i) the case of either suspected or definite malignancy in cytology, which was benign in histopathology; ii) from the set defined as above, all lesions of 'follicular neoplasm/tumour' cytological subcategory were excluded and treated as negative results (with respect to malignancy diagnosis); iii) 'follicular neoplasm/ tumour' were excluded from analysis.…”
Section: Methodsmentioning
confidence: 98%
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“…The diagnostic value of FNAB (with the exclusion of non-diagnostic outcomes) was assessed in terms of sensitivity, specificity, positive and negative predictive values. In the specific epidemiological situation in Poland, with relatively recent iodine prophylaxis, the risk of cancer -if follicular neoplasm has been discovered with FNAB -is lower than in the case of other suspected lesions (16). Thus, three different definitions of false positive (FP) diagnosis were applied: i) the case of either suspected or definite malignancy in cytology, which was benign in histopathology; ii) from the set defined as above, all lesions of 'follicular neoplasm/tumour' cytological subcategory were excluded and treated as negative results (with respect to malignancy diagnosis); iii) 'follicular neoplasm/ tumour' were excluded from analysis.…”
Section: Methodsmentioning
confidence: 98%
“…The category 'malignant lesions' included the outcomes with malignant tumour diagnosed. The precise methods of classifying FNAB outcomes into categories were fully described previously (16,20).…”
Section: Methodsmentioning
confidence: 99%
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