Fine Needle Aspiration Biopsy of Breast Lesions and Histopathologic Correlation

Rocha, Premila De Souza; Nadkarni, Nisha; Menezes, S

doi:10.1159/000332689

Cited by 20 publications

(9 citation statements)

References 8 publications

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“…[13] and 41-75 years in the study by Rocha et al . [6] Unsatisfactory lesions were common in the age groups 21-60 years in the present study and 14-50 years in the study by Rocha et al . [6] So overall pattern of occurrence is as expected with benign lesions are seen in younger age group and suspicious and malignant in older age group.…”

Section: Discussionsupporting

confidence: 55%

“…[6] and Domínguez et al . [7] One possible cause is, present study is carried out in tertiary cancer hospital in rural area and has higher referrals of patients with diagnosed or likely to be diagnosed breast cancers.…”

Section: Discussionmentioning

confidence: 99%

“…[12] and Rocha et al . [6] who had maximum cytological benign cases in the age groups 15-44 years and 14-40 years respectively. MacIntosh et al .…”

Section: Discussionmentioning

confidence: 99%

“…In the present study, cytological suspicious lesions were most common in the age group 31-70 fs almost similar findings have been reported by MacIntosh et al . [13] and Rocha et al .,[6] who reported maximum number of suspicious cases in the age groups 33-75 years and 31-75 years, respectively. Malignant lesions were common in the age groups 31-70 years in the present study, 35-84 years in the study by Khemka et al .,[12] 63-79 years in the study by MacIntosh et al .…”

Section: Discussionmentioning

confidence: 99%

“…This is in agreement with the findings of other studies like Rocha et al . [6] (45.20%), Zuk et al . [10] (42.20%), Reddy and Reddy[14] (54.20%), Meena et al .…”

Section: Discussionmentioning

confidence: 99%

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Cytological study of palpable breast lumps presenting in an Indian rural setup

Sankaye

Dongre

2014

Indian Journal of Medical and Paediatric Oncology

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Introduction:Benign as well as malignant breast lesions are quite common in Indian population. It is the second most common cancer site after cancer cervix. Fine-needle aspiration cytology (FNAC) is safe, reliable, and time saving outdoor procedure with little discomfort to the patient. FNAC is useful in diagnosis and further planning of treatment without need for biopsy. The current study was carried out with aims of studying the frequency of various breast lesions on FNAC in a rural area in India and its histopathological correlation.Materials and Methods:This was 2 years prospective study carried out from May 2010 to April 2012. Physical examination of breast mass by palpation was done. Smears were stained with May-Grunwald Giemsa and Papanicolaou stain.Results:Of the 225 cases, 131 were in the benign category and 65 belonged to the malignant category, while the cytology study of 13 cases was unsatisfactory. Seventy-six cases were available for histological correlation. Of 29 cytological benign cases, 26 were confirmed as benign, but 3 turned out to be malignant. Out of 36 cytological malignant cases, 35 were confirmed as malignant. FNAC was 88.37% sensitive and 96.42% specific in diagnosing malignant lesions.Conclusion:Fine-needle aspiration cytology is a rapid and effective method for the primary categorization of palpable breast lumps into benign, malignant, atypical, suspicious, and unsatisfactory categories. Benign breast lesions are common than malignant lesions. Histological correlation indicated FNAC to be a good diagnostic tool.

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Section: Discussionsupporting

confidence: 55%

Section: Discussionmentioning

confidence: 99%

“…[12] and Rocha et al . [6] who had maximum cytological benign cases in the age groups 15-44 years and 14-40 years respectively. MacIntosh et al .…”

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

“…This is in agreement with the findings of other studies like Rocha et al . [6] (45.20%), Zuk et al . [10] (42.20%), Reddy and Reddy[14] (54.20%), Meena et al .…”

Section: Discussionmentioning

confidence: 99%

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Cytological study of palpable breast lumps presenting in an Indian rural setup

Sankaye

Dongre

2014

Indian Journal of Medical and Paediatric Oncology

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Effectiveness of fine‐needle aspiration cytology of breast: Analysis of 2,375 cases from northern Thailand

Chaiwun

Settakorn

Ya-In

et al. 2002

Diagnostic Cytopathology

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At the Maharaj Nakorn Chiang Mai Hospital, Chiang Mai, Thailand, 2,375 cases of breast lesions were sampled by fine-needle aspiration (FNA) from 1994-1999. Cytologic diagnoses were: benign (48%), suspicious for malignancy (5%), malignant (15%), and unsatisfactory (32%). Comparison with histology was possible in 721 cases. The diagnoses obtained by FNA showed a sensitivity of 84.4%, specificity of 99.5%, positive predictive value of 99.8%, negative predictive value of 84.3%, false-negative rate of 16.7%, false-positive rate of 0.5%, and overall diagnostic accuracy of 91.3%. We conclude that, in experienced hands, FNA of breast masses is reliable for diagnosis. Assessment of samples at the time of aspiration can reduce the number of inadequate specimens to near zero. Correlation of FNA results with clinical and radiologic findings can identify false-negatives and false-positives, ensuring optimal patient management. Many centers now recommend needle core biopsy instead of FNA. For regions such as ours, the added cost of this test would make it unavailable to many patients, which could delay a diagnosis of breast cancer. We advocate keeping FNA as a first-line diagnostic procedure, at least in areas under economic restrictions, in order to maximize the availability of health care to women with breast disease.

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Bilateral primary lymphoma of the breast: A case report initially diagnosed by FNAC

Maounis¹,

Ellina²,

Papadaki³

et al. 2005

Diagnostic Cytopathology

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Primary lymphoma of the breast (PLB) is a rare disease, representing 0.04-0.5% of all malignant breast neoplasms. We present a patient with bilateral breast involvement by a high-grade diffuse large B-cell lymphoma, which was diagnosed initially by fine-needle aspiration cytology (FNAC). Mammography revealed a diffuse increase in density of the right breast and a large solitary mass on the left breast, suggestive of an inflammatory carcinoma. The patient underwent FNAC and the diagnosis of a non-Hodgkin's lymphoma (NHL) was suggested. Physical examination revealed palpable bilateral axillary lymph nodes but no evidence of concurrent widespread disease. The patient underwent complete staging evaluation. The only positive findings were an elevated lactate dehydrogenase (LDH) and evidence of axillary lymphadenopathy on CT. Excisional biopsy was performed on the left breast. The morphological and immunohistochemical analysis confirmed the diagnosis of a high-grade diffuse large B-cell lymphoma with an immunophenotype suggestive of a germinal center cell origin.

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Fine Needle Aspiration Biopsy of Breast Lesions and Histopathologic Correlation

Cited by 20 publications

References 8 publications

Cytological study of palpable breast lumps presenting in an Indian rural setup

Cytological study of palpable breast lumps presenting in an Indian rural setup

Effectiveness of fine‐needle aspiration cytology of breast: Analysis of 2,375 cases from northern Thailand

Bilateral primary lymphoma of the breast: A case report initially diagnosed by FNAC

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