Fine Needle Aspiration Cytodiagnosis of Apocrine Carcinoma of the Breast

Gupta, Raj K.; McHutchison, Andrew G. R.; Simpson, Judith; Dowle, Carl S.

doi:10.1111/j.1365-2303.1992.tb00055.x

Cited by 10 publications

(2 citation statements)

References 7 publications

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“…The cytology after fine needle aspiration may have a role in orienting. As in our patient, it shows apocrine cells with cell and nuclear atypias, a large irregular nucleus and a prominent nucleolus with abundant cytoplasm [ 3 ]. Macroscopically, apocrine carcinoma is in the form of a nodule or endo-cystic growths, often multicentric [ 1 ].…”

Section: Discussionmentioning

confidence: 83%

Apocrine carcinoma of the male breast: a case report of an exceptional tumor

Sekal¹,

Znati²,

Harmouch³

et al. 2014

Pan Afr Med J

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Apocrine carcinoma of the male breast is an exceptional malignant tumor. It does not have a particular clinical or radiological appearance, but it's microscopically characterized by the presence of granular cells and foamy cells representing over 90% of tumor cells. These cells express most of the time the GCDFP-15 and the androgen receptors. This tumor is a distinct molecular entity. In this observation, we report the case of a 70 year old man presenting apocrine carcinoma of the left breast diagnosed at the stage of lung metastasis.

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Section: Discussionmentioning

confidence: 83%

Apocrine carcinoma of the male breast: a case report of an exceptional tumor

Sekal¹,

Znati²,

Harmouch³

et al. 2014

Pan Afr Med J

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show abstract

“…The pathological difficulties in diagnosing the present case by FNA and Trucut biopsy were compounded by the large amount of necrotic material in the initial samples, coupled with the moderately irregular but acutely inflamed apocrine tissue. It is possible to successfully diagnose apocrine carcinoma with FNA but this requires marked nuclear abnormalities, and the diagnosis should be confirmed by open biopsy 4 , 5 …”

Section: Discussionmentioning

confidence: 99%

APOCRINE DUCTAL CARCINOMA IN SITU OF THE BREAST PRESENTING AS A CHRONIC ABSCESS

Kenwright¹,

Gaskell

Wakefield

et al. 1999

Aust. N.Z. J. Surg.

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Fine‐needle aspiration cytologic features of four special types of breast cancers: Mucinous, medullary, apocrine, and papillary

Haji

Das

Al-Ayadhy

et al. 2007

Diagnostic Cytopathology

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Recognition of special types of breast cancers by fine-needle aspiration (FNA) cytology may have prognostic implications but some difficulties still exist in the ability of cytopathologists to determine the tumor subtypes. Detailed cytomorphological features were studied in the four special and unusual types of breast cancer cases (8 cases of mucinous, 9 medullary, 9 apocrime, and 11 papillary) and compared between themselves and with those of 32 duct cell carcinomas, not otherwise specified (NOS). Papillary carcinomas were also compared with 10 benign papillary lesions. The significance of the differences was determined using Fishers' Exact Test of Probability. In mucinous carcinoma, the frequency of signet ring cells (62.5%), and background pools of mucin (87.5%) were significantly higher than those of duct cell carcinoma (NOS), medullary carcinoma, apocrine carcinoma, and papillary carcinoma (P = 0.0408 to < 0.0001). In medullary carcinomas, lymphomononuclear cell infiltration (100.0%) was observed in significantly higher number of cases than in papillary, mucinous, and apocrine types (P < 0.0001). Further, moderate to marked nuclear pleomorphism (100.0%) and nuclear irregularity (77.8%) was significantly higher than those of mucinous carcinoma and papillary carcinoma (P = 0.0294 to <0.0003). Abnormal apocrine cells and papillary formation, characterizing all the apocrine carcinomas and papillary carcinomas, respectively, were present in significantly lower number in other variants and in duct cell carcinoma (NOS) (P = 0.0002 to <0.0001). Glycogen vacuoles (63.6%) were observed in a significantly higher number of papillary carcinoma as compared to duct cell carcinoma (NOS), apocrine, and medullary carcinomas (P = 0.0047 to 0.0022). The significant parameters differentiating papillary carcinoma and benign papillary lesions were loose cohesive clusters (P = 0.001) and acinar formation by neoplastic cells (P = 0.0237). Histopathology reports available in 36 cases, confirmed the cytodiagnosis of carcinoma in all 35 cases and the benign lesion in one case. Cytological subtyping was confirmed in 13 of 16 special types of carcinomas and all the 15 duct cell carcinoma (NOS). Thus, special and unusual variants of duct cell carcinomas like mucinous, medullary, apocrine, and papillary have specific cytomorphological features, which differentiate them from one another and from duct cell carcinoma (NOS). However, differentiating features between papillary carcinoma and benign papillary lesions were very few in this study.

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Fine Needle Aspiration Cytodiagnosis of Apocrine Carcinoma of the Breast

Cited by 10 publications

References 7 publications

Apocrine carcinoma of the male breast: a case report of an exceptional tumor

Apocrine carcinoma of the male breast: a case report of an exceptional tumor

APOCRINE DUCTAL CARCINOMA IN SITU OF THE BREAST PRESENTING AS A CHRONIC ABSCESS

Fine‐needle aspiration cytologic features of four special types of breast cancers: Mucinous, medullary, apocrine, and papillary

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