Fine-needle aspiration cytologic diagnosis of intrahepatic biliary papillomatosis (intraductal papillary tumor): Report of three cases and comparative study with cholangiocarcinoma

Tsui, Wilson M. S.; Lam, Polly W.Y.; Mak, C.K.L.; Pay, K.H.

doi:10.1002/(sici)1097-0339(200005)22:5<293::aid-dc7>3.0.co;2-e

Cited by 24 publications

(10 citation statements)

References 19 publications

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“…However, the evidence that supports this theory is still scant. Although more than half of the patients reported by authors were from Asian countries,1,3,4,,,16 it is not clear whether any racial, geographical, or cultural factors may account for this apparent difference.…”

Section: Discussionmentioning

confidence: 94%

“…The small hepatoma found in the right lobe was not detected in preoperative computed abdominal tomography. Including this patient, there were altogether four cases in the literature diagnosed incidentally without any typical biliary symptoms 14,16…”

Section: Discussionmentioning

confidence: 99%

“…A search of the English literature was carried out in the MEDLINE database of our local library system using “biliary papillomatosis” as the keyword. All the reported cases since 1993 are summarized in Table 2 1,…”

Section: Methodsmentioning

confidence: 99%

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Biliary papillomatosis: report of seven cases and review of English literature

Yeung

AhChong

Chung

et al. 2003

Journal of Hepato-Biliary-Pancreatic Surgery

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Biliary papillomatosis is rare. Before 1993, there were only 21 cases reported in the English literature. This article reports our experience in managing this disease and reviews experiences from recent English literature. A retrospective review of patients with biliary papillomatosis was conducted in our institution. A search of the English literature between 1993 and 2002 was performed in the MEDLINE database using "biliary papillomatosis" as the keyword. Seven patients with biliary papillomatosis were treated in our hospital. Another 50 cases were reported in the recent literature. This amounted to a total of 78 cases so far reported. The male to female ratio was approximately 2 : 1. The mean age at presentation was 63 years. Most patients presented typically with cholangitis. Malignant change was present in 33 patients (42%). Concomitant intrahepatic and extrahepatic disease was noticed in 33 patients (42%). The overall resection rate was 55%. The mean survival was 28 months following resection, irrespective of histological type. Patients without tumor resection had a poorer survival of less than 11 months. Biliary papillomatosis presents typically with biliary obstruction and it occurs most often in elderly males. Resection is recommended because of the considerable malignancy rate, diffuse pattern of disease, and better survival following curative surgery. Malignant histology is not always associated with a poorer prognosis provided that radical resection can be achieved.

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Section: Discussionmentioning

confidence: 94%

Section: Discussionmentioning

confidence: 99%

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Biliary papillomatosis: report of seven cases and review of English literature

Yeung

AhChong

Chung

et al. 2003

Journal of Hepato-Biliary-Pancreatic Surgery

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“…Diagnosis is possible by means of ERCP and endoscopic biopsy for extrahepatic cases, and percutaneous transhepatic cholangioscopy and fine needle aspiration for intrahepatic tumors. [60][61][62] IPN is not infrequently associated with invasive carcinoma, in particular the mucinous subtype. 58 Pathologic Differential Diagnosis Hepatolithiasis is frequently mistaken for several other diseases in which there may be secondary stone formation (Table 1).…”

Section: Complicationsmentioning

confidence: 99%

Hepatolithiasis and the Syndrome of Recurrent Pyogenic Cholangitis: Clinical, Radiologic, and Pathologic Features

et al. 2011

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Primary hepatothiasis (HL) and recurrent pyogenic cholangitis (RPC) are two terms describing the different aspects of the same disease, with HL emphasizing the pathologic changes and RPC emphasizing the clinical presentation and suppurative inflammation. It is predominantly a disease of the Far East. In the 1960s, it was the third most common cause of emergency abdominal surgery at a university hospital in Hong Kong. Thereafter, its incidence has decreased considerably, possibly due to improved standards of living and Westernized diet. Clinically, patients may present acutely with recurrent bacterial cholangitis and its possible complications, such as liver abscess and septicemic shock, or with chronic complications, such as cholangiocarcinoma. Pathologically, it is characterized by pigmented calcium bilirubinate stones within dilated intrahepatic bile ducts featuring chronic inflammation, mural fibrosis, and proliferation of peribiliary glands, without extrahepatic biliary obstruction. Episodes of suppurative inflammation cumulate in sclerosing cholangitis of peripheral ducts and parenchymal fibrosis resulting from collapse and scarring. Mass-forming inflammatory pseudotumor and neoplasms like intraductal papillary neoplasms and cholangiocarcinoma are increasingly recognized complications. Modern imaging techniques allow definitive diagnosis, accurate assessment for treatment planning, and detection of complications. A multidisciplinary team approach (interventional endoscopist, interventional radiologist, hepatobiliary surgeon, and intensivists) is important for optimal patient outcome.

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“…Recently, a collection of fine needle aspiration features have been described to help distinguish BP from cholangiocarcinoma. These included a hypercellular smear with double-cell layered sheets of ductal columnar epithelium, papillary configuration, preserved honeycomb pattern with equal nuclear spacing and dysplasia (9).…”

Section: Discussionmentioning

confidence: 99%

Well Differentiated Intrahepatic Cholangiocarcinoma in the Setting of Biliary Papillomatosis: A Case Report and Review of the Literature

Cox

Ma²,

Bridges³

et al. 2005

Canadian Journal of Gastroenterology

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A 64-year-old man presented with long-standing, vague, epigastric abdominal pain. History, physical examination and laboratory studies were noncontributory. However, serial computed tomography scans revealed a rapidly progressive mass in segment 2 of the liver. Surprisingly, surgical pathology revealed a well-differentiated intrahepatic cholangiocarcinoma associated with biliary papillomatosis (BP). BP is a rare, benign and potentially fatal disease of the intra- and extrahepatic bile ducts. It is typified by numerous multicentric papillary fronds arising from biliary columnar epithelium. Most patients present with symptoms of jaundice and cholangitis. Although a benign disease, a review of the literature demonstrated that BP often recurs after surgical resection, carries a poor prognosis and has a moderately high malignant transformation rate. Treatment options for BP include surgical resection, transplant, ablation, stenting and/or bypass.

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Fine-needle aspiration cytologic diagnosis of intrahepatic biliary papillomatosis (intraductal papillary tumor): Report of three cases and comparative study with cholangiocarcinoma

Cited by 24 publications

References 19 publications

Biliary papillomatosis: report of seven cases and review of English literature

Biliary papillomatosis: report of seven cases and review of English literature

Hepatolithiasis and the Syndrome of Recurrent Pyogenic Cholangitis: Clinical, Radiologic, and Pathologic Features

Well Differentiated Intrahepatic Cholangiocarcinoma in the Setting of Biliary Papillomatosis: A Case Report and Review of the Literature

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