Fine Needle Aspiration Cytologic Findings of Micropapillary Carcinoma in the Lung

Duncan, Lisa; Jacob, Sanjivini V.; Atkinson, S.A.

doi:10.1159/000325808

Cited by 6 publications

(5 citation statements)

References 23 publications

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“…24 In a case report, Duncan et al reported the presence of an avascular papillary structures and cell balls composed of overlapping atypical nuclei. 23 Both studies accept the presence of small papillary clusters lacking a fibrovascular core as characteristic for the cytological diagnosis of micropapillary adenocarcinoma in the lung.…”

Section: Discussionmentioning

confidence: 94%

“…The cytologic materials were evaluated for several cytomorphologic features including cellularity, presence or absence of flat sheets, characterized by monolayer sheets of cells; threedimensional papillary configurations characterized by branched glandular epithelium; papillary clusters with fibrovascular core; acinar clusters, characterized by berryshaped clusters of cells with central lumen, large tridimensional clusters of neoplastic cells with smooth bor-ders; and micropapillary tufts, characterized by small tight clusters of neoplastic cells devoid of fibrovascular cores, as described previously. 23,24,27 Each of these cytological patterns are illustrated in Figures 1 and 2.…”

Section: Methodsmentioning

confidence: 99%

“…The micropapillary (MPP) type of adenocarcinoma has been described in the breast, [5][6][7][8][9][10][11][12][13] urinary bladder, [14][15][16] ovary, 17 salivary gland, 18,19 colon, 20,21 and lung. [22][23][24][25][26][27][28][29][30] MPP adenocarcinoma has been defined histologically as a morule-like cluster of neoplastic cells within spaces of a fine network of fibroconnective tissue. 5,7,12 Some authors added the lack of fibrovascular core to the small papillary tufts to the definition of MPP adenocarcinoma, 5,13,15,24,29 and others described that the cell clusters in MPP adenocarcinoma have nuclei located centrally with a rim of cytoplasm toward the periphery (inside-out pattern of a glandular like structure).…”

mentioning

confidence: 99%

“…[31][32][33] There have been few studies, mostly case reports, describing the cytologic characteristics of MPP adenocarcinoma. 5,[7][8][9]12,13,23,24,26 In the lung, however, these findings have not been validated. This study was undertaken with the goal of evaluating if the presence of the micropapillary pattern in cytological material correlates with the presence of MPP adenocarcinoma in histological sections of the same tumor.…”

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confidence: 99%

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Cytologic diagnosis of pulmonary adenocarcinoma with micropapillary pattern: Does it correlate with the histologic findings?

Rudomina

Lin

Moreira

2009

Diagnostic Cytopathology

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Micropapillary adenocarcinoma is associated with poor-prognosis in several organs including the lung. The presence of small tight balls of neoplastic cells devoid of fibrovascular core in cytological preparations (micropapillary tufts) has been described as characteristic of micropapillary adenocarcinoma. In the lung, however, this criterion has not been validated. The cytological material of 46 cases of histologically proven pulmonary adenocarcinoma with a micropapillary component was compared to 33 cases with no micropapillary component to determine the specificity of micropapillary tufts for the histologic diagnosis of micropapillary adenocarcinoma. Other histologic patterns of invasive pulmonary adenocarcinomas (acinar, papillary, and solid) were also compared with patterns of neoplastic cell aggregates in cytological preparations. There were no significant differences in the distribution of micropapillary clusters between the two groups. The positive predictive value for the cytologic diagnosis of a micropapillary component in lung adenocarcinomas was of 64%. Similar findings were observed for other invasive patterns. Therefore, the detection of micropapillary tufts in cytology is not specific for the diagnosis of a pulmonary micropapillary adenocarcinoma in the lung.

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Section: Discussionmentioning

confidence: 94%

Section: Methodsmentioning

confidence: 99%

mentioning

confidence: 99%

mentioning

confidence: 99%

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Cytologic diagnosis of pulmonary adenocarcinoma with micropapillary pattern: Does it correlate with the histologic findings?

Rudomina

Lin

Moreira

2009

Diagnostic Cytopathology

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“…Their avascular papillary structures and cell clusters were composed of overlapping atypical nuclei with irregular nuclear membranes and prominent nucleoli. In addition, they described many discohesive individual cells and clear spaces at the periphery of the cell balls, accentuated with Romanowsky stain [14]. These features were to diagnosis micropapillary carcinoma at the time and some are still used.…”

Section: Discussionmentioning

confidence: 99%

Micropapillary Adenocarcinoma of the Lung that Metastasized to the Same Site in the Brain Twice: A Rare Case Report and Review of Literature

Faried

Agung

Agustina

et al. 2020

Open Access Maced J Med Sci

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BACKGROUND: Adenocarcinoma (ADC) of the lung is the most common subtype of non-small cell lung cancer (NSCLC), occurring in ~40% of all patients with significantly higher incidence of brain metastasis compared with other subtypes of NSCLC. Among the five subtypes ADC of the lung, micropapillary predominant ADC may be more likely to metastasize. There are almost no reports of micropapillary ADC of the lung initially discovered to metastasis into the same site in the brain that has been previously operated. CASE REPORT: We reported a 54-year-old woman who was referred to ICU of Dr. Hasan Sadikin Hospital, Bandung, due to a decreased of consciousness. Head computed tomography scan revealed multiple isohypodense lesions in the right frontal with brain edema. She had craniotomy total tumor removal 8 months earlier and diagnosed as brain metastasis due to micropapillary ADC of the lung. She refused to receive chemoradiotherapy. At the operation site, multilobulated lesions were found, and hence, she was operated for the 2nd time at the same site with the first one, exhibited the same histology. Immunohistological shown positive results for thyroid transcription factor (TTF)-1 and cytokeratin (CK)-7; negative for CK-20, led to a diagnosis of micropapillary ADC of the lung. CONCLUSION: Herein, we reported our experience regarding a case of micropapillary ADC of the lung, considered as poorly differentiated ADC and associated with a high-grade lesion that metastasized to the same site that had been previously operated, twice. A definitive diagnosis was possible only through a histopathological examination along with a good communication between the surgeon and the pathologist.

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Primary Epithelial Malignancies

Erozan¹,

Ramzy²

2009

Pulmonary Cytopathology

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Fine Needle Aspiration Cytologic Findings of Micropapillary Carcinoma in the Lung

Cited by 6 publications

References 23 publications

Cytologic diagnosis of pulmonary adenocarcinoma with micropapillary pattern: Does it correlate with the histologic findings?

Cytologic diagnosis of pulmonary adenocarcinoma with micropapillary pattern: Does it correlate with the histologic findings?

Micropapillary Adenocarcinoma of the Lung that Metastasized to the Same Site in the Brain Twice: A Rare Case Report and Review of Literature

Primary Epithelial Malignancies

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