Fine Needle Aspiration Cytology Diagnosis of a Fungal Lesion of the &lt;i&gt;Verticillium&lt;/i&gt; Species

Das, Dilip K.; Grover, Rajesh K.; Chachra, Krishan Lal; Bhatt, Naveen C.; Misra, Bibhabati

doi:10.1159/000332560

Cited by 9 publications

(4 citation statements)

References 7 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…12 This ratified the previous finding of aspergillus in urine and renal casts. Direct extension from adjacent structures is a well-known etiology for liver abscesses, easily explaining the liver involvement of our patient.…”

supporting

confidence: 85%

Primary renal aspergillosis: extremely uncommon presentation in patients treated with bone marrow transplantation

Medeiros

Cunha

Pasqüini

et al. 1999

Bone Marrow Transplant

View full text Add to dashboard Cite

Summary:Invasive aspergillosis affects 3 to 11% of BMT patients with a high mortality rate (60 to 95%). Extra-pulmonary disease is an unusual event, and primary renal aspergillosis is extremely uncommon. A patient with CML treated with BMT, who developed primary renal and subsequently hepatic aspergillosis, is described. Dysfunction of the mucosal barrier secondary to conditioning therapy, was a possible portal of entry for the fungus. Fine needle aspiration was very useful, as is direct microscopic examination of the urine, for diagnosis of the fungal infection. Surgical drainage of the abscess followed by antifungal therapy is the treatment of choice. Unconducive situations, such as refractory thrombocytopenia, are associated with the worst outcome in these patients. Keywords: bone marrow transplantation; primary renal aspergillosis; disruption of mucosal barrier; fine needle aspiration; surgical approach; antifungal therapy Invasive aspergillosis is a devastating infection that affects mainly immunocompromised hosts. Between 3 and 11% of BMT patients develop Aspergillus infections, especially with A. fumigatus and A. flavus.1,2 Primary renal aspergillosis is extremely uncommon; only 23 cases have previously been described in the literature and four of these are in AIDS patients. 3 We report a case of primary renal aspergillosis with extension to the liver in a BMT patient, which is, as far as the authors know, the first reported case. Case reportA 49-year-old male with CML in chronic phase, with a good performance status and no previous infection history, received an HLA-identical allogeneic BMT. He was conditioned with busulphan 4 mg/kg p.o. in divided doses daily for 4 days (total dose 16 g/kg) and cyclophosphamide 60Correspondence: Dr CR de Medeiros, Serviço de Transplante de Medula Ó ssea, Hospital de Clínicas, Rua General Carneiro, 181, 15°andar 80060-900, Curitiba, Paraná, Brazil Received 26 October 1998; accepted 12 February 1999 mg/kg daily i.v. on days 1 and 2 (total dose 120 g/kg). Immunoprophylaxis of GVHD was with cyclosporin A, methotrexate and prednisone. On day +7, mucositis grade III was noticed. On day +16, he developed abdominal pain and ultrasound revealed a stone in the right renal pelvis, with no evidence of urinary obstruction. On day +29, hematuria was noticed, followed by passage of the renal stone. On examination this was demonstrated to be composed of aspergillus. Direct microscopic examination of the urine showed fragments of hyaline and septate hyphae, also suggestive of aspergillus, with A. fumigatus growing on urine culture. Amphotericin B (1 mg/kg/day) was started. An abdominal CT scan was carried out a week later because of persisting abdominal pain. This revealed hypodense lesions in both kidneys. The liver also had a hypodense lesion contiguous to the right kidney abscess, most likely due to direct extension from the renal lesion (Figure 1). An extensive study was carried out, including CT scan of lungs and sinuses, looking for the portal of entry of the fungus which was not ...

show abstract

supporting

confidence: 85%

Primary renal aspergillosis: extremely uncommon presentation in patients treated with bone marrow transplantation

Medeiros

Cunha

Pasqüini

et al. 1999

Bone Marrow Transplant

View full text Add to dashboard Cite

show abstract

“…Demonstration of fungal forms on smears makes FNAC very sensitivity and specificity of the test. 9 FNAC smears from a nodule near elbow showed necrotic inflammatory background. Since the patient was a known case of leprosy, special stain was performed which demonstrated plenty of lepra bacilli.…”

Section: Discussionmentioning

confidence: 96%

Cytomorphology of periarticular nodular swellings: One year study

2020

JDPO

View full text Add to dashboard Cite

Introduction: Periarticular nodular swellings represent one of the common manifestations of a wide variety of non-neoplastic and neoplastic lesions. It poses diagnostic challenge for both the clinicians and pathologists due to overlapping signs and symptoms and nonspecific laboratory findings. FNAC helps in categorizing these lesions as inflammatory, degenerative, benign and malignant and offers an early diagnosis. Aims and Objectives: To categorise different nodular swellings around synovial joints of upper and lower limbs and to study the Cytomorphology of these lesions. Materials and Methods: An observational case study of 100 patients with Periarticular nodules of upper and lower extremities referred to the cytology OPD of GMC, Nagpur Maharashtra, over one-year duration. Results: Commonest lesion found was ganglion cyst in 37% patients, followed by lipoma in 18% patients, epidermal cyst in 13% patients, inflammatory lesions in 11% patients, giant cell tumor of tendon sheath in 8% patients, benign mesenchymal tumors in 7% patients. Other interesting cases included gout in 2% patients, rheumatoid nodule, ochronosis, xanthoma, nerve abscess, synovial sarcoma, chloroma and metastasis of squamous cell carcinoma in 1% each.

show abstract

“…3 Other reports have implicated Verticillium species in stromal keratitis in a 50-year-old immunocompetent man 4 and presented a case of soft tissue infection from Verticillium species in a patient with juvenile diabetes mellitus. 5 Verticillium species has also been reported to cause endop hthalmitis following cataract surgery. 11 Here, we report a patient with Verticillium species infection involving skin and soft tissue who presented with symptoms after living-donor related renal transplant.…”

Section: Discussionmentioning

confidence: 99%

“…Verticillium is a fungus rarely associated with human disease. [1][2][3][4][5] Here, we report a case of skin and soft tissue infection in a patient who had received a renal transplant.…”

Section: Introductionmentioning

confidence: 99%