Fine Needle Aspiration Cytology in Breast Disease Management—a 4 Year Experience

Hiller, Grit Gesine Ruth; Harney, M.C.; Legg, Stephen; Hart, Stewart

doi:10.1111/j.1445-2197.1987.tb01347.x

Cited by 7 publications

(2 citation statements)

References 4 publications

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“…These techniques assess therapeutic effects by either over-or underestimating the extent of residual disease due to fibrosis or sampling error (2,6,(11)(12)(13)(14)(15)(16). Although histology is the gold standard, the histological correlation of response with all of the above-mentioned modalities is not satisfactory.…”

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confidence: 99%

Monitoring the therapeutic response of locally advanced breast cancer patients: Sequential in vivo proton MR spectroscopy study

Kumar

Jagannathan

Seenu

et al. 2006

Magnetic Resonance Imaging

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PurposeTo evaluate the use of the water‐to‐fat (W‐F) value obtained from in vivo proton (1H) MR spectroscopy (MRS) as a response indicator of cytologically confirmed patients with locally advanced breast cancer (LABC), and to monitor the therapeutic response of such patients to neoadjuvant chemotherapy (NACT)Materials and MethodsSerial 1H MR spectra were recorded both before and after the completion of chemotherapy in 33 LABC patients (with infiltrating ductal carcinoma (IDC)) at 1.5T. In addition, spectra from normal breast tissues of 28 healthy volunteers were recorded.ResultsMalignant breast tissues showed elevated W‐F values compared to normal breast tissues of controls. Statistically significant higher pretherapy W‐F value (P < 0.01) was observed in patients compared to controls. In patients who received NACT resulting in the reduction of the primary tumor size, the W‐F value showed a decrease that was statistically significant (P < 0.01). Analysis of the MR data further indicates that the W‐F value had no correlation with the menstrual status of the patients. A comparison of pretherapy W‐F value with pretherapy tumor volume showed a fair correlation (P = 0.05), while the posttherapy W‐F value showed no such correlation with the posttherapy tumor volume.ConclusionThis study demonstrates that simple, conventional in vivo 1H MRS is a useful technique for monitoring the therapeutic response of breast cancer patients. The observed trend in the reduction of W‐F value provides a noninvasive response indicator to monitor the clinical outcome of locally advanced breast cancer patients to NACT J. Magn. Reson. Imaging 2006. © 2006 Wiley‐Liss, Inc.

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confidence: 99%

Monitoring the therapeutic response of locally advanced breast cancer patients: Sequential in vivo proton MR spectroscopy study

Kumar

Jagannathan

Seenu

et al. 2006

Magnetic Resonance Imaging

View full text Add to dashboard Cite

show abstract

“…Whether this lower unsatisfactory rate was the result of the skill (better at performing FNA) or of the technique (repeating unsatisfactory FNAs to obtain sufficient material prior to issuing a report) of the cytopathologist performing NPFD could not be determined from our data. Breast FNA unsatisfactory rates are influenced by patient factors-age, 18 lesion size, 2,18,21 lesion palpability (discrete lump or thickening), 6,7,10,15,20,23 benign or malignant histology, 6,18,20 and histologic type 2,21,24 -and operator factors. 3,4,16,18,25,26 Palombini et al noted better results from series in which the cytopathologist who interpreted the smears also performed the FNA.…”

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confidence: 99%