Fine Needle Aspiration Cytology of a Thyroid Metastasis of Metaplastic Breast Carcinoma

Gong, Yun; Jalali, Mehri; Staerkel, Gregg

doi:10.1159/000326158

Cited by 14 publications

(5 citation statements)

References 19 publications

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“…In the studies that contained histological information, primary breast cancer was mostly referred to as "invasive" carcinoma (85.7%), indicating that invasive carcinoma might be the most prevalent type of cancer to result in TM (Table 1 ). Among those reports, two patients had poorly differentiated adenocarcinoma as the primary disease[ 11 ], one patient had medullary carcinoma[ 11 ], one had metaplastic carcinoma[ 23 ], and one had mucinous carcinoma[ 7 ].…”

Section: Discussionmentioning

confidence: 99%

Metastasis to the thyroid gland from primary breast cancer presenting as diffuse goiter: A case report and review of literature

Wen¹,

Jiang²,

Wen³

et al. 2022

WJCC

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BACKGROUND Metastasis to the thyroid gland (TM) from primary breast cancer is uncommon and usually presents as thyroid nodules; however, diffuse goiter without thyroid nodules is the first sign of TM in rare cases. Skip metastases (SMs) to the lymph nodes in breast cancer, defined as discontiguous higher-level metastases in the absence of lower levels of contiguous metastases, have been reported in the contralateral cervical area of the primary tumor site in rare cases. CASE SUMMARY A 49-year-old previously healthy Chinese woman was diagnosed with right lateral invasive ductal carcinoma and underwent neoadjuvant chemotherapy treatment and bilateral mastectomy with axillary lymph node dissection. No malignancy of the left breast or axillary or distant metastases were identified preoperatively. However, enlarged left cervical lymph nodes were detected 36 mo after surgery, and rapidly enlarging thyroid glands without nodules were detected 42 mo after surgery. Fine-needle aspiration cytology was performed on the left cervical lymph nodes and left lobe of the thyroid, which were both revealed to contain metastases from the primary breast cancer. Additionally, the immunostaining profiles changed in the process of metastases. The patient was discharged with the NP (vinorelbine and cisplatin) regimen for subsequent treatment, and stable disease was determined when the curative effect was evaluated. CONCLUSION Diffuse goiter may be the first sign of TM, and enlarged lymph nodes in the contralateral cervical area may be SMs of primary breast cancer.

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Section: Discussionmentioning

confidence: 99%

Metastasis to the thyroid gland from primary breast cancer presenting as diffuse goiter: A case report and review of literature

Wen¹,

Jiang²,

Wen³

et al. 2022

WJCC

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“…Однако ультразвуковые признаки при наличии узлов в щитовидной железе не позволяют различать первичные и вторичные опухоли. Цитологический метод и иммуногистохимическое исследование являются основными в установлении диагноза при вторичном поражении щитовидной железы [19][20][21][22]. При этом иммуногистохимическое исследование позволяет дифференцировать метастатический рак молочной железы от первичной опухоли щитовидной железы.…”

Section: Discussionunclassified

Synchronous thyroid gland metastases from breast cancer. Case reports

Огнерубов

Алексеевич²,

Antipova³

et al. 2021

J. Mod. Onco.

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Background. Breast cancer is the leading cause of death in women. Distant metastases in different organs, including the thyroid gland, are still an urgent problem. Distant metastases are very rare in clinical practice. Nevertheless, the accumulated clinical and surgical experience in treatment has shown that breast cancer is the second most common primary tumor, leading to thyroid gland metastases, after kidney cancer. Aim. Present the clinical observations of synchronous thyroid gland metastases from breast cancer. Materials and methods. We observed two patients, aged 55 and 72 years, suffering from metastatic breast cancer with simultaneous metastases to the thyroid gland, to the cervical and mediastinal lymph nodes, to the lungs, to the ovaries and to the bones. Results. A 55-year-old woman with a left sided neck mass and hoarseness has been suffering from the metastatic breast cancer with simultaneous metastases to the thyroid gland, to the cervical lymph nodes, to the lungs, to the ovaries and to the bones. The biopsy of the primary tumor has been performed. The tumor has the structure of invasive ductal carcinoma, G2, luminal A subtype, HER2-negative type in histological and immunohistochemical analysis. The spread of the tumor has been determined by positron emission tomography/computed tomography (PET/CT). Metastases from breast cancer have been cytologically proven during thin needle biopsy. A 72-year-old woman with a mass in the region of thyroid gland has been suffering from breast cancer with metastases to the thyroid gland, to the mediastinal and cervical lymph nodes, to the bones, and to determine this process PET/CT, the thyroid fine needle aspiration biopsy and core biopsy of primary tumor have been applied. The histological variant was represented by invasive ductal cancer, G2, luminal A subtype, HER-2 negative type. Taking into account the spread of the process, the patients were given polychemotherapy, targeted therapy and hormone therapy. There is no disease progression for 6 months. Conclusion. Synchronous thyroid gland metastases in case of primary breast tumors are rare. In such cases, PET/CT is the important diagnostic method. The main therapeutic option in this case is systemic therapy, including chemotherapy, targeted and hormone therapy, the nature of the agent depends on the biological variant of the tumor.

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“…According to the literature, the involvement of the thyroid generally becomes apparent either simultaneously or anywhere in the range from a few months to 14 years after the original diagnosis of the primary tumor [1,[8][9][10][11][12][13][14][15]. The long interval between the original primary tumor and subsequent thyroid metastases presents a diagnostic problem.…”

Section: Discussionmentioning

confidence: 99%

“…Although thyroid metastases from breast cancer are uncommon, the routine use of fine-needle aspiration may better assist in its more frequent detection due to its ready ability to confirm a clinical suspicion [6,14]. Total thyroidectomy is recommended for patients with metastatic cancer limited to the thyroid because of the multifocality of metastases to the thyroid gland [17].…”

Section: Discussionmentioning

confidence: 99%

Thyroid gland metastasis from breast cancer: A rare case report and literature overview

Inić

Martinovic

Inić³

et al. 2018

Srp Arh Celok Lek

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Introduction The thyroid gland is a rare site for metastatic lesions from non-thyroid cancers. Due to the fact that achieving a diagnosis of thyroid gland metastasis from breast cancer prior to operation is challenging, the diagnosis thereof is mainly based on a pathological biopsy and immunohistochemical staining. The aim of this study was to present a rare case of thyroid gland metastasis from lobular breast cancer. Case outline The patient was a 33-year-old female who had already had a five-year history of lobular cancer of the right breast and was thereafter found to have two suspicious tumors in the left breast, as well as a thyroid mass diagnosed as metastatic breast carcinoma. Conclusion Patients who have a thyroid lesion and a history of malignancy are at a higher risk for metastasis and require additional caution during diagnosis and treatment.

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Fine Needle Aspiration Cytology of a Thyroid Metastasis of Metaplastic Breast Carcinoma

Cited by 14 publications

References 19 publications

Metastasis to the thyroid gland from primary breast cancer presenting as diffuse goiter: A case report and review of literature

Metastasis to the thyroid gland from primary breast cancer presenting as diffuse goiter: A case report and review of literature

Synchronous thyroid gland metastases from breast cancer. Case reports

Thyroid gland metastasis from breast cancer: A rare case report and literature overview

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