Fine needle aspiration cytology of invasive micropapillary carcinoma of the breast

Lui, Pauline Po Yee; Lau, Patrick S. Y.; Tse, Gary; Tan, Puay Hoon; Lo, Ronald; Tang, Vikki; Ng, Wai Kuen; Somali, Anjali; Mak, Kong Ling; Thomas, Teresa M. M.; Chan, Ngot Htai; Hiang, Tin Tin; Chan, Norman

doi:10.1080/00313020701444499

Cited by 14 publications

(2 citation statements)

References 21 publications

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“…FNA is a relatively easy biopsy method with a number of documented cases of breast MPC diagnosed using this approach (10,13,14). However, few cases of MPC in the urinary bladder have been reported, possibly due to the inapplicability of FNA and the availability of urine as the only cytological sample (15,16).…”

Section: Discussionmentioning

confidence: 99%

Cytological features of pure micropapillary carcinoma of various organs: A report of eight cases

Huq¹,

Canberk

Öznur

et al. 2014

Oncology Letters

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Micropapillary carcinoma (MPC) is a rare aggressive tumor, which generally accompanies the primary carcinoma of the organ of its origin, while the pure form is extremely uncommon. Angiolymphatic involvement is widespread and a considerable proportion of the cases present with metastases. The current study presents eight pure MPC cases arising from the breast (n=3), urinary bladder (n=3), parotid gland (n=1) and lung (n=1, presenting with pericardial effusion), with the cytological findings. The eight patients included three female and five male cases aged between 48 and 74 years. The most common cytological findings were three-dimensional aggregates, cell clusters with angulated or scalloped borders, single cells with a columnar configuration and eccentric nuclei, and high-grade nuclear features. Histopathological sections showed accompanying in situ ductal carcinoma in the cases of MPC arising in the parotid gland and breast (n=3), and one case in the bladder exhibited only in situ MPC. The average follow-up period was 20 months (range, 6–54 months) and, during this period, three patients succumbed to the disease. At present, four patients are alive with disease and one patient is alive and disease-free. In conclusion, cytology is an important tool for the diagnosis and management of MPC.

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Section: Discussionmentioning

confidence: 99%

Cytological features of pure micropapillary carcinoma of various organs: A report of eight cases

Huq¹,

Canberk

Öznur

et al. 2014

Oncology Letters

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“…Since then, several researchers have examined the clinical outcomes and pathologic features of IMPC [3, 4]. In the 2003 World Health Organization (WHO) guidelines for histologic classification of tumors of the breast [5], IMPC was listed as a rare subtype of invasive breast carcinoma, accounting for approximately 2% to 8% of all breast cancers [6–8].…”

Section: Introductionmentioning

confidence: 99%

Clinicopathologic study of invasive micropapillary carcinoma of the breast

Tang

Yang

et al. 2017

Oncotarget

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Invasive micropapillary carcinoma (IMPC) is a rare subtype of breast carcinoma. It is presumed to be more aggressive than invasive ductal carcinoma (IDC), though it is uncertain whether the prognoses of IMPC and IDC differ. In this retrospective study, we compared the clinicopathologic characteristics and survival between 170 female patients with IMPC (pure or mixed with IDC) and 728 with pure IDC. The IMPC patients had higher clinical stages and histologic grades, higher incidences of lymphovascular invasion and axillary lymph node extracapsular extension, and a higher degree of lymph node involvement than IDC patients. Moreover, IMPC was associated with increases in estrogen receptor (ER) and progesterone receptor (PR) positivity and HER-2 overexpression. Although locoregional recurrence-free survival (LRRFS) and recurrence-free survival (RFS) were poorer in IMPC patients than IDC patients, overall survival and distant metastasis survival did not differ between the two groups. Multivariate analysis revealed that IMPC was an independent prognostic factor for LRRFS in breast cancer, and IMPC patients had poorer clinicopathologic characteristics and poorer RFS and LRRFS than IDC patients. We therefore suggest that to improve treatment decisions, patients with breast carcinoma be tested for the presence of this specific subtype.

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