Fine Needle Aspiration Cytology of Clear Cell Carcinoma of the Gallbladder with Hepatic In.ltration

Vaillo, A.; Rodriguez-Recio, F J; Gutiérrez-Martín, Antonia; Ballestı́n, Claudio; Ruiz-Liso, Juan Manuel

doi:10.1159/000326418

Cited by 9 publications

(2 citation statements)

References 19 publications

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“…The cytoplasm of most of the cells is rich in glycogen and sometimes contains vacuoles of mucin. 10 However, many other malignant lesions may also show similar characteristics, such as metastatic clear cell renal carcinoma of the gallbladder, 11 – 14 clear cell carcinoma of the ovary, 15 endometrial clear cell carcinoma, 16 the malignant clear cell sugar tumor of the lung, 17 and other tumors with clear cell differentiation. The most important differential diagnosis is to distinguish renal clear cell carcinoma from hepatocellular carcinoma, especially with direct invasion of the liver.…”

Section: Discussionmentioning

confidence: 99%

A clear cell adenocarcinoma of the gallbladder with hepatoid differentiation: case report and review of literature

Zhang¹,

Zhang²,

Mu³

et al. 2016

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An 80-year-old male was referred to our department for a gallbladder mass. He denied any history of alcohol consumption or cholecystitis and smoking. Hepatitis B surface antigen test and antihepatitis C antibody test were found to be negative. Serum carbohydrate antigen 19-9 (CA19-9) and carcinoembryonic antigen were elevated (CA19-9 was 59.92 U/mL and carcinoembryonic antigen was 12.64 ng/mL), whereas alpha-fetoprotein was below the normal limit (2.46 ng/mL). Computed tomography scan revealed a solid mass with measurements of 4.6×5.6×7.1 cm, which nearly filled the whole gallbladder space. Radical cholecystectomy, including segments IV B and V of the liver and lymphadenectomy, was performed. The neoplasm in gallbladder was completely resected, and the patient obtained a negative margin. Histological and immunohistochemical profile suggested a clear cell adenocarcinoma of the gallbladder with hepatoid differentiation. After reviewing the literature, we reported that this case is the first identified case of cell adenocarcinoma of the gallbladder with extensive hepatoid differentiation. However, clinical features of clear cell adenocarcinoma with hepatoid differentiation remain unclear due to the extremely rare incidence. There was no indication of adjuvant chemotherapy and no literature has been reported on the application of chemotherapy. This case showed a promising clinical outcome after curative resection, which indicated that surgical treatment could be potentially considered for suitable patients.

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Section: Discussionmentioning

confidence: 99%

A clear cell adenocarcinoma of the gallbladder with hepatoid differentiation: case report and review of literature

Zhang¹,

Zhang²,

Mu³

et al. 2016

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“…Case Reports in Surgery Adenocarcinoma is the most common histological type of GBC [15], whereas the clear cell subtype is diagnosed exceedingly rare. Since 1926, which is considered the year that the first case of the clear cell subtype was reported, up to 2021 only 19 cases are published [5,[16][17][18][19][20][21][22][23][24][25]. Thus, CCG accounts for less than 1% of all gallbladder malignancies [16].…”

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confidence: 99%

Gallbladder Clear Cell Carcinoma: Report of a Rare Case and Literature Review

Papatheodorou

Frantzeskou

Konstantinou

et al. 2023

Case Reports in Surgery

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Carcinoma of the gallbladder is the most common biliary tract cancer. The majority of gallbladder cancers are adenocarcinomas, whereas clear-cell carcinoma of the gallbladder (CCG) is a rarely recorded variant. Usually, diagnosis is established incidentally after cholecystectomy, performed for another reason. Clinically, the different histological types of carcinomas are impossible to be recognized preoperatively, since they present with a wide and common range of symptoms. We present a male patient who underwent an emergency cholecystectomy due to suspected perforation. After an uneventful postoperative period, the histopathological report led to the diagnosis of CCG, but the surgical margins were infiltrated by the tumor. The patient decided not to proceed with any additional treatment and passed away 8 months after the operation. In conclusion, it is of great necessity to record such unusual cases and enriches global knowledge with information clinically and educationally noteworthy.

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Variant Adenocarcinomas of the Gallbladder

Zimmermann¹

2016

Tumors and Tumor-Like Lesions of the Hepatobiliary Tract

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Fine Needle Aspiration Cytology of Clear Cell Carcinoma of the Gallbladder with Hepatic In.ltration

Cited by 9 publications

References 19 publications

A clear cell adenocarcinoma of the gallbladder with hepatoid differentiation: case report and review of literature

A clear cell adenocarcinoma of the gallbladder with hepatoid differentiation: case report and review of literature

Gallbladder Clear Cell Carcinoma: Report of a Rare Case and Literature Review

Variant Adenocarcinomas of the Gallbladder

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