Fine Needle Aspiration Cytology of Squamous Cell Carcinoma Arising in a Thyroglossal Duct Cyst

Ranieri, E; D’Andrea, Mario; Vecchione, Andrea

doi:10.1159/000333951

Cited by 16 publications

(12 citation statements)

References 9 publications

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“…This is consistent with the findings of the present series, which yielded a suspicious or definitive diagnosis of malignancy in 5 of 12 (42 %) patients in which preoperative fine needle aspiration was performed. This lack of efficacy has been attributed largely to poor cellular yield secondary to the cystic nature of the lesion and the often relatively small size of the malignant component [37][38][39][40][41][42][43].…”

Section: Discussionmentioning

confidence: 99%

Thyroglossal Duct Cyst Carcinomas: A Clinicopathologic Series of 22 Cases with Staging Recommendations

Thompson

Herrera

Lau³

2016

Head and Neck Pathol

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Carcinomas arising from thyroglossal duct remnant cysts (TGDCs) are rare, without well-defined management and staging criteria. All TGDCs (n = 685) diagnosed between 2005 and 2015 were retrospectively reviewed, with 22 carcinomas identified (3.2 % incidence). Twenty-two patients (17 females, 5 males), aged 12-64 years (mean 39.9 years; median 39 years) were identified. An anterior, superior midline neck mass was the presenting symptom in all patients. A cancer diagnosis [all papillary thyroid carcinoma (PTC)] was made after the Sistrunk procedure (SP), with a Bethesda Category V or VI classification preoperatively by fine needle aspiration in 5 of 12 cases tested. A SP was performed in all patients, with total thyroidectomy concurrently (n = 4) or subsequently (n = 12). A selected neck dissection was performed in 5 patients, with metastases found in 3. Of the patients who had a thyroidectomy, syn-

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Section: Discussionmentioning

confidence: 99%

Thyroglossal Duct Cyst Carcinomas: A Clinicopathologic Series of 22 Cases with Staging Recommendations

Thompson

Herrera

Lau³

2016

Head and Neck Pathol

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“…In addition, there are several reports of squamous-cell carcinoma (SCC) arising in TDCs. [15][16][17] Pathology of these reveals keratinizing carcinoma, but in addition displays ciliated columnar epithelium as a component of the cyst. The histogenetic origin of SCC is attributed to the metaplastic portion of the TDC.…”

Section: Discussionmentioning

confidence: 99%

Thyroglossal duct cyst: A cytopathologic study of 26 cases

et al. 2005

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Thyroglossal duct cyst (TDC), or embryologic remnants of thyroid gland, is a common congenital anomaly. TDC may cause a midline neck mass, which occasionally may become infected, and rarely gives rise to carcinoma. As a number of other nonneoplastic and neoplastic lesions can cause cystic masses in the neck, we explored the role of fine-needle aspiration (FNA) in making a preoperative diagnosis of TDC for a more accurate and timely clinical intervention. Twenty-six cases of TDC were identified from the cytopathology files of The Johns Hopkins Hospital in a 15-yr period (1990-2004). Material was obtained by FNA with or without radiologic (ultrasound) guidance. Smears were air-dried and stained with Diff-Quik, or wet-fixed and stained with Papanicolaou stain. Cytomorphologic characteristics were serially analyzed. Follow-up (tissue resection [n = 9] and clinical charts [n = 17]) was reviewed in all cases. Patients ranged in age from 8 to 83 yr (mean age, 55) with M:F ratio of 1.4:1. The size of the cyst ranged from 1.2 to 5 cm (mean 2.5 cm), as evaluated on radiological scans. The most common clinical presentation was a non-tender, mobile neck mass, which was painful on swallowing. Follow-up confirmed TDC in 18/26 cases (69%), whereas 8/26 cases resulted in various other benign lesions. During the same time period, 11/18 (61%) cases of surgically resected TDC were missed on prior FNA. Therefore, FNA showed a diagnostic sensitivity of 62% and a positive predictive value (PPV) of 69% for the diagnosis of TDC. The cytomorphologic features of TDC included the following: colloid (thick and fragmented, thin and watery, or mucinous), macrophages, lymphocytes, or predominantly neutrophils. The epithelium was ciliated columnar, metaplastic squamous or of mature squamous type. Thyroid epithelium was only rarely present (11%). FNA is only moderately sensitive for a preoperative evaluation of TDC. Cytomorphologic features are not unique; however, in the right clinicoradiologic setting should lead to an accurate diagnosis. Abundant colloid, most often with ciliated columnar epithelium, is the predominant cytopathologic finding. Thyroid epithelium is rarely identified. Differential diagnosis involves branchial cleft cyst, lymphoepithelial cyst, thyroid gland lesions, and lymphadenopathy (of various etiologies).

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“…If a reliable diagnosis of TGDC carcinoma can be made preoperatively, a more appropriate surgical intervention may be planned (3). Thus, FNA is considered to be important for preoperative assessment of TGDC (6). However, the present case did not exhibit malignant features, and FNA did not detect any malignant cells, with the final diagnosis being confirmed during pathology.…”

Section: Discussionmentioning

confidence: 49%

“…Squamous cell carcinoma arising from a TGDC is rare, and is associated with a poor prognosis. Only 24 cases of squamous cell carcinoma arising from a TGDC have currently been reported in the literature (Table I) (5,6,. The median age at presentation is 57.2 years, and the male-to-female ratio is 13/9.…”

Section: Discussionmentioning

confidence: 99%

Adenosquamous carcinoma arising from a thyroglossal duct cyst: A case report

Chang

2016

Oncology Letters

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Abstract. The current study describes a case of adenosquamous carcinoma originating from a thyroglossal duct cyst (TGDC). A 77-year-old man presented with an asymptomatic mass in the left mid-neck, which was soft and mobile on palpation. Fine-needle aspiration was performed, but cytology did not detect any malignant cells. Computed tomography demonstrated a single cystic lesion in the left lobe of the thyroid gland; therefore, surgery was performed on the suspected thyroid cyst. However, it was identified intraoperatively that the lesion was separated from the thyroid gland and instead adhered to an additional hyoid bone; therefore, the Sistrunk procedure was performed. Histopathological examination of the resected tumor confirmed the diagnosis of adenosquamous carcinoma originating from a TGDC. Carcinoma arising from a TGDC is rare, and accounts for 1% of all TGDC cases. The most common subtype of carcinoma associated with TGDC is papillary carcinoma, whilst adenosquamous carcinoma developing from a TGDC is extremely rare, with only one case currently reported in the literature. Although a consensus for the management of this disease has not yet been established, adequate surgical excision with long-term follow-up is currently the preferred treatment.

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Fine Needle Aspiration Cytology of Squamous Cell Carcinoma Arising in a Thyroglossal Duct Cyst

Cited by 16 publications

References 9 publications

Thyroglossal Duct Cyst Carcinomas: A Clinicopathologic Series of 22 Cases with Staging Recommendations

Thyroglossal Duct Cyst Carcinomas: A Clinicopathologic Series of 22 Cases with Staging Recommendations

Thyroglossal duct cyst: A cytopathologic study of 26 cases

Adenosquamous carcinoma arising from a thyroglossal duct cyst: A case report

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