Fine Needle Aspiration Cytology of a Pancreatic Cyst in a Patient with Autosomal Dominant Polycystic Kidney Disease

Silverman, Jan F.; Prichard, Jeffrey W.; Regueiro, Miguel

doi:10.1159/000327641

Cited by 14 publications

(6 citation statements)

References 30 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The fact that Tg737 function is required to control intracellular localization of β-catenin, and that nuclear localized β-catenin has been found in several murine pancreatic tumors (Kongkanuntn et al, 1999), is intriguing as it provides further evidence for a previously suggested direct link between PKD and pancreatic cancer formation (Niv et al, 1997;Silverman et al, 2001). Acinar-to-ductal metaplasia, which is, at least in some cases, due to chronic pancreatitis, has been proposed as one of the mechanisms that predispose for the formation of pancreatic ductal adenocarcinomas (Malka et al, 2002).…”

Section: Pkd Acinar-to Ductal Metaplasia and Pancreatic Adenocarcinomamentioning

confidence: 95%

orpkmouse model of polycystic kidney disease reveals essential role of primary cilia in pancreatic tissue organization

et al. 2004

View full text Add to dashboard Cite

Polycystic kidney disease (PKD) includes a group of disorders that are characterized by the presence of cysts in the kidney and other organs,including the pancreas. Here we show that in orpk mice, a model system for PKD that harbors a mutation in the gene that encodes the polaris protein, pancreatic defects start to occur at the end of gestation, with an initial expansion of the developing pancreatic ducts. Ductal dilation continues rapidly after birth and results in the formation of large,interconnected cysts. Expansion of pancreatic ducts is accompanied by apoptosis of neighboring acinar cells, whereas endocrine cell differentiation and islet formation appears to be unaffected. Polaris has been shown to co-localize with primary cilia, and these structures have been implicated in the formation of renal cysts. In the orpk pancreas, cilia numbers are reduced and cilia length is decreased. Expression of polycystin-2, a protein involved in PKD, is mislocalized in orpk mice. Furthermore, the cellular localization of β-catenin, a protein involved in cell adhesion and Wnt signaling, is altered. Thus, polaris and primary cilia function are required for the maturation and maintenance of proper tissue organization in the pancreas.

show abstract

Section: Pkd Acinar-to Ductal Metaplasia and Pancreatic Adenocarcinomamentioning

confidence: 95%

orpkmouse model of polycystic kidney disease reveals essential role of primary cilia in pancreatic tissue organization

et al. 2004

View full text Add to dashboard Cite

show abstract

“…Patients with cystic fibrosis may present with simple cysts within a diffuse atrophic fatty pancreatic parenchyma, 13 and patients with autosomal dominant polycystic renal disease and medullary cystic disease may have cystic transformation of the pancreas. 14,15 Pancreatic Pseudocysts The Atlanta classification of acute pancreatitis was revised in 2013, and the terminology to define inflammatory pancreatic fluid collections was updated and improved. According to the revised criteria, inflammatory pancreatic fluid collections were categorized as acute peripancreatic fluid collections, PPs, acute necrotic collections, and walled-off necrosis.…”

Section: Nonneoplastic Cystsmentioning

confidence: 99%

My Treatment Approach: Pancreatic Cysts

Başar

Brugge

2017

Mayo Clinic Proceedings

View full text Add to dashboard Cite

Our treatment approach for either symptomatic or incidentally found pancreatic cysts continues to improve. The true incidence of pancreatic cysts is not known, and pancreatic cystic neoplasms, especially intraductal papillary mucinous neoplasms, are currently most commonly diagnosed and resected. This is a result of increasing awareness, widespread availability of imaging, and better understanding of the nature of pancreatic cysts as well. Recent studies on molecular analysis and devices such as microbiopsy forceps help us better define and select the treatment approach to alleviate symptoms and to prevent malignant tumors while avoiding unnecessary surgery.

show abstract

“…In pancreatic tissue, cilia are found exclusively in islet and ductal cells; cilia are absent in acinar cells (Cano et al, ; Zhang et al, ). A link between cilia defects and pancreatic abnormalities was suggested by the 10% increased risk of pancreatic lesions in PKD patients (Torra et al, ; Silverman et al, ; Basar et al, ).…”

Section: The Role Of Primary Cilia In Pancreatic Tissuementioning

confidence: 99%

Role of cilia in normal pancreas function and in diseased states

Diiorio

Rittenhouse

Bortell

et al. 2014

Birth Defects Research Pt C

View full text Add to dashboard Cite

Primary cilia play an essential role in modulating signaling cascades that shape cellular responses to environmental cues to maintain proper tissue development. Mutations in primary cilium proteins have been linked to several rare developmental disorders, collectively known as ciliopathies. Together with other disorders associated with dysfunctional cilia/centrosomes, affected individuals have increased risk of developing metabolic syndrome, neurologic disorders, and diabetes. In pancreatic tissues, cilia are found exclusively in islet and ductal cells where they play an essential role in pancreatic tissue organization. Their absence or disorganization leads to pancreatic duct abnormalities, acinar cell loss, polarity defects, and dysregulated insulin secretion. Cilia in pancreatic tissues are hubs for cellular signaling. Many signaling components, such as Hh, Notch, and Wnt, localize to pancreatic primary cilia and are necessary for proper development of pancreatic epithelium and β-cell morphogenesis. Receptors for neuroendocrine hormones, such as Somatostatin Receptor 3, also localize to the cilium and may play a more direct role in controlling insulin secretion due to somatostatin's inhibitory function. Finally, unique calcium signaling, which is at the heart of β-cell function, also occurs in primary cilia. Whereas voltage-gated calcium channels trigger insulin secretion and serve a variety of homeostatic functions in β-cells, transient receptor potential channels regulate calcium levels within the cilium that may serve as a feedback mechanism, regulating insulin secretion. This review article summarizes our current understanding of the role of primary cilia in normal pancreas function and in the diseased state.

show abstract

Fine Needle Aspiration Cytology of a Pancreatic Cyst in a Patient with Autosomal Dominant Polycystic Kidney Disease

Cited by 14 publications

References 30 publications

orpkmouse model of polycystic kidney disease reveals essential role of primary cilia in pancreatic tissue organization

orpkmouse model of polycystic kidney disease reveals essential role of primary cilia in pancreatic tissue organization

My Treatment Approach: Pancreatic Cysts

Role of cilia in normal pancreas function and in diseased states

Contact Info

Product

Resources

About