Fine Needle Aspiration Cytology of Oncocytic Lipoadenoma of the Parotid Gland

Oncocytic Lipoadenoma of the Salivary Gland: A Clinicopathologic Analysis of 7 Cases and Review of the Literature

“…Mixed lipomatous and epithelial tumors where the latter component is comprised of oncocytes have been termed oncocytic lipoadenoma, which appear to be unique to salivary glands. Oncocytic lipoadenoma is rare; to date twenty cases have been reported in the literature (Table 2) [12][13][14][15][16][17][18][19][20][21][22][23][24]. The ''adenoma'' designation highlights the predominance of the epithelial component, rather than sialolipoma which emphasizes the fatty component.…”

“…The tumor occurs slightly more frequently in men than women, with a male to female ratio of 1.5:1. Patients typically present with a painless, slowly growing mass or swelling that has not uncommonly been present for an extended duration of time (mean 34.5 months; range 2-180 months) [12,14,15,[17][18][19][20][21]23]. The vast majority of oncocytic lipoadenomas have originated in the parotid gland, with only few reports of submandibular gland involvement [12,16,22].…”

“…The oncocytes are usually arranged in nests and acini with a microscopic appearance resembling a conventional oncocytoma. The lipomatous component of the tumor has the appearance of mature adipose tissue and can comprise as little as 5 % to as much as 80 % of the tumor volume [12][13][14][15][16][17][18][19][20][21][22][23][24]. The adipocytes may be relatively evenly dispersed among the oncocytes, or may be irregularly distributed with either the oncocytic or lipomatous component predominating in a given area of the tumor.…”

“…First described in 1998, oncocytic lipoadenoma is a histologically distinctive tumor composed of oncocytic cells and mature adipocytes [12]. The tumor is decidedly rare; with only a few examples in the literature, mostly as case reports [13][14][15][16][17][18][19][20][21][22][23][24]. With scant published data, we analyzed seven new cases of oncocytic lipoadenoma in order to further delineate the clinicopathologic features of this unusual salivary gland neoplasm, combined with a thorough review of the literature.…”

Preoperative Cytodiagnosis of Pleomorphic Adenoma with Extensive Lipometaplasia

“…Recently we reported a case of oncocytic lipoadenoma, cytologically characterized by the presence of clusters and sheets of oncocytes, intimately associated with mature adipose tissue; in that particular case, as we were unaware of an entity called "oncocytic lipoadenoma" preoperatively, the adipose tissue component was ignored by us. 8 the lipomatous component seen on the cytologic smears of the present case; that prompted an easy diagnosis of pleomorphic adenoma with lipometaplasia based on the components of a classic pleomorphic adenoma intimately admixed with highly prominent lipomatous tissue. Owing to the coexistence of fibromyxoid stroma and adipose tissue elements, another remote possibility considered was a spindle cell lipoma, which could easily be excluded by the associated epithelial and myoepithelial components.…”