Fine needle aspiration cytology of lymphoproliferative lesions of the oral cavity

Cozzolino, I; Vigliar, Elena; Todaro, Paolo; Peluso, Andrea; Picardi, Marco; Fernandez, Laura Sosa; Mignogna, Michele Davide; Tuccari, Giovanni; Selleri, Carmine; Zeppa, Pio

doi:10.1111/cyt.12132

Cited by 36 publications

(23 citation statements)

References 33 publications

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“…In clinical practice, these procedures are generally used when histology and immunohistochemistry are equivocal or difficult to perform [37,43], but have also been used on cytological samples, including nodal and extranodal FNC samples [36,52,53]. In particular, IGH/TCR PCR can confirm FNC/FC diagnoses of lymphoma or assess polyclonality, adding clinical value to the FNC diagnoses of nodal and extranodal processes [40,54]. Mayall et al [55] maintain that, because of its high efficiency and short turnaround time, IGH/TCR PCR may replace FC on FNC samples, whereas Davidson et al [56] suggested that their combined use should be advisable because of a relatively high rate of monoclonality detection by PCR only.…”

Section: Pcr-based Assaysmentioning

confidence: 99%

Lymph Node Fine-Needle Cytology: Beyond Flow Cytometry

Peluso

Ieni²,

Mignogna³

et al. 2016

Acta Cytologica

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Lymph node (LN) fine-needle cytology (FNC) coupled with flow cytometry immunophenotyping provides relevant information for the diagnosis of non-Hodgkin lymphoma (NHL). Numerous studies have shown FNC samples to be suitable for different molecular procedures; in this review, some of the molecular procedures most commonly employed for NHL are briefly described and evaluated in this perspective. Fluorescence in situ hybridization and chromogenic in situ hybridization are briefly described. Polymerase chain reaction (PCR)-based assays are used to identify and quantify mutations and translocations, namely immunoglobulin (IGH) and T-cell receptor rearrangements by clonality testing and IGVH somatic hypermutations either by Sanger sequencing, single-strand conformational polymorphisms or RT-PCR strategies. High-throughput technologies (HTT) encompass numerous and different diagnostic tools that share the capacity of multiple molecular investigation and sample processing in a fast and reproducible manner. HTT includes gene expression profiling, comparative genomic hybridization, single-nucleotide polymorphism arrays and next-generation sequencing technologies. A brief description of these tools and their potential application to LN FNC is reported. The challenge for FNC will be to achieve new knowledge and apply new technologies to FNC, exploiting its own basic qualities.

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Section: Pcr-based Assaysmentioning

confidence: 99%

Lymph Node Fine-Needle Cytology: Beyond Flow Cytometry

Peluso

Ieni²,

Mignogna³

et al. 2016

Acta Cytologica

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“…During the second year of life, most of the hemangiomas get an involution phase, and 50% of the lesions are completely healed without scares and changes in the skin colors. Anyway, the involution process can cause laxity of the tissues, scarring, production of fibro-fatty mass and teleangectasias [9]. Theories about hemangioma development include abnormalities in fetal vasculogenesis period at the sixth-tenth week of fetal life, and are not hereditary [1–4].…”

Section: Discussionmentioning

confidence: 99%

“…Another theory for hemangiomas placental origin advocates a fetal vessel embolization with placental cells in the district sites of the hemangioma lesion [1–4]. Other studies support this theory by the observation of 3 to 4 times higher incidence of hemangiomas in children whose mothers had undergone chorion or trophoblast biopsy [6,7,9]. Also, the related estrogen and hormone levels hemangiomas growth can be explained with the placental origin of hemangiomas.…”

Section: Discussionmentioning

confidence: 99%

“…Also, the related estrogen and hormone levels hemangiomas growth can be explained with the placental origin of hemangiomas. Other theories suggest the developmental field disturbance for the hemangiomas origin evidenced by the association with other developmental malformation like PHACE syndrome (acronym for Posterior fossa brain malformation, hemangioma, arteriocerebral vascular anomalies, aortic cohartation, cardiac defects and eye defects and endocrine abnormalities), Sturge-Weber and Kasabach-Merritt syndrome [9]. On the other side, theories about vascular malformation origin suggest a relation with abnormalities of vascular tissue morphogenesis [6,7].…”

Section: Discussionmentioning

confidence: 99%

“…At physical examination, a right cervical lymph node and a thyroidal nodule were detected. Before the treatment of the vascular treatment, a fine-needle cytology examination of both the lesions was performed as reported elsewhere [9–18]. FNAC demonstrated a benign hyperplasia of the lymph node and a nodular goiter of the thyroid.…”

Section: Clinical Casementioning

confidence: 99%

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Hemangiomas of the maxillofacial area: Case Report, Classification and Treatment Planning

et al. 2015

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Vascular lesions of the maxillofacial area are even more challenging than in other different body district, because of the high aesthetic and functional relevance of this area for the sense organs presence like eye, brain, tongue, ear and nose. For these reasons, we propose an accurate classification based on hemodynamic and histologic aspects usefulthat is for diagnostic and therapeutic planning. A female, 60 years old patient came to our observation showing a vascular lesion of the lower left lip, and complaining for aesthetical and functional impairment. To confirm the diagnosis of vascular malformation and to detect lesion flow rate or other possible localization, a Tc red blood cell scintigraphy was carried out. Result was a venous low flow lesion; hence, sclerotherapy by a 3% Polidocanol solution (Atossisclerol) followed by surgery was planned. The aim of this work was to propose a diagnostic and therapeutic scheme with an integration of ISSVA and a flow rate classifications for a three-step planning based on 1) the biological findings in an early age at the lesion discover with a pharmacological treatment; 2) Hemodynamic study of the lesions at growing age followed by sclerotherapy or embolization; 3) Imaging study of these lesions for patients candidate to surgery when after step 1 and step 2 diagnostic and therapeutic planning results were incompletely successful.

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The Sydney system for lymph node FNA biopsy cytopathology: A detailed analysis of recent publications and meta‐analysis and a proposal for the components of an ideal prospective study of a cytopathology reporting system

Liang,

Cozzolino,

Zeppa

et al. 2024

Cancer Cytopathology

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BackgroundThe Sydney system for fine‐needle aspiration biopsy of lymph nodes has five categories, stressing the role of correlation of cytopathology with clinical, ultrasound, and ancillary findings to achieve diagnosis. The five categories constitute a hierarchical system with increasing risk of malignancy from benign to atypical, suspicious, and malignant categories, which informs recommendations for further workup to achieve a final diagnosis as possible. This article analyzes 10 publications using the Sydney system and a meta‐analysis of nine of these studies. The primary goal of the analysis is to ascertain the causes of the large ranges in risk of malignancy for the “atypical” and “inadequate” compared to “benign,” “suspicious,” and “malignant” categories, which were comparable to well‐established reporting systems. Research protocols are proposed to improve future studies.MethodsPubMed literature search from January 2021 to December 2023 identified studies evaluating performance of the Sydney system.ResultsTen studies showed heterogeneity with clinical setting, study design, ultrasound use and rapid on‐site evaluation, operator, cutoff points for “positive” cases, with inherent partial verification biases, resulting in a wide range of risk of malignancy, specificity, and sensitivity values.ConclusionAnalysis shows the large range is due to heterogeneity of the studies, which suffer from biases and variable statistical analysis that are ultimately included in any meta‐analysis, detracting from the usefulness of the risk of malignancy derived by the meta‐analysis. Components for ideal analyses of reporting systems are presented.

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Fine needle aspiration cytology of lymphoproliferative lesions of the oral cavity

Cited by 36 publications

References 33 publications

Lymph Node Fine-Needle Cytology: Beyond Flow Cytometry

Lymph Node Fine-Needle Cytology: Beyond Flow Cytometry

Hemangiomas of the maxillofacial area: Case Report, Classification and Treatment Planning

The Sydney system for lymph node FNA biopsy cytopathology: A detailed analysis of recent publications and meta‐analysis and a proposal for the components of an ideal prospective study of a cytopathology reporting system

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