Fine Needle Aspiration Cytology of Benign Fibrous Histiocytoma of Bone

Bharatnur, Shankaranand Siddappa; Naik, Chamarajanagar Nanjanayak Ramesh; Swethadri, Gumballi Krishnamurthy; Fernandes, Hilda; Shekhar, Jayaprakash Chandra; Marla, Nisha J

doi:10.1159/000324976

Cited by 4 publications

(6 citation statements)

References 7 publications

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“…Differential diagnoses included xanthoma, lipidised BFH and ceruminous adenoma. Cytology smears of lipidised BFH, in addition to foamy histiocytes, show cohesive clusters of spindle cells with fine chromatin and intervening thin capillary network; sparse mitotic activity may be noted in the clusters 15,16 . Touton giant cells are rarely seen.…”

Section: Discussionmentioning

confidence: 98%

Solitary adult xanthogranuloma in external auditory canal: Cyto‐histopathological correlation of an uncommon entity at an uncommon site

Misra

Gupta

2020

Diagnostic Cytopathology

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Juvenile xanthogranulomas (JXG) are the most common type of self‐limiting non‐Langerhans cell histiocytosis (LCH) usually presenting in infancy and early childhood. Clinically, they present as solitary to multiple rounded cutaneous nodules which resolve over time. Adult type xanthogranulomas (AXG), though histologically similar to JXG, are usually single and do not regress spontaneously. AXG arising in the external auditory canal (EAC) is a rare occurrence with very few cases reported in literature. We present a case of AXG in a 48‐year‐old man, arising from the right EAC. This case is unique as it is the only case to be described with both cytology and histology correlation. On cytology, smears showed scattered foamy histiocytes, inflammatory cells and thick stromal fragments. Cytology differential diagnoses of xanthomatous lesion, benign fibrous histiocytoma (BFH) and ceruminous adenoma were given; final diagnosis was deferred to histopathology which confirmed it to be an AXG. Thus, it is important to keep the diagnosis of AXG in mind while dealing with solitary polypoidal lesions in EAC showing prominent foam cell component. Lipidised BFH forms a close differential diagnosis, however can be excluded by subtle points on cytology and on histopathology.

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Section: Discussionmentioning

confidence: 98%

Solitary adult xanthogranuloma in external auditory canal: Cyto‐histopathological correlation of an uncommon entity at an uncommon site

Misra

Gupta

2020

Diagnostic Cytopathology

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“…FH shows short and intersecting fascicles of spindle cells with a loose crisscross pattern or an inconspicuous storiform arrangement occasionally associated with multinucleated giant cells (either foreign body or Touton type). Cytologic features of FH, including that arising from the breast, have been described . Spindle cell‐rich FNA smears of FH show more distinct arrangement such as in sheets, papillary fronds, and storiform pattern than in NF.…”

Section: Discussionmentioning

confidence: 99%

“…Cytologic features of FH, including that arising from the breast, have been described . Spindle cell‐rich FNA smears of FH show more distinct arrangement such as in sheets, papillary fronds, and storiform pattern than in NF. Foam cells, siderophages, roundish or polygonal histiocytic cells, and occasionally Touton‐type multinucleated giant cells are seen .…”

Section: Discussionmentioning

confidence: 99%

“…Spindle cell‐rich FNA smears of FH show more distinct arrangement such as in sheets, papillary fronds, and storiform pattern than in NF. Foam cells, siderophages, roundish or polygonal histiocytic cells, and occasionally Touton‐type multinucleated giant cells are seen . These cytologic findings can be utilized for the differential diagnosis.…”

Section: Discussionmentioning

confidence: 99%

“…Foam cells, siderophages, roundish or polygonal histiocytic cells, and occasionally Touton-type multinucleated giant cells are seen. 63,64 These cytologic findings can be utilized for the differential diagnosis.…”

Section: Discussionmentioning

confidence: 99%

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Fine needle aspiration cytology of nodular fasciitis of the breast

Sakuma¹,

Matsuo

Koike³

et al. 2014

Diagnostic Cytopathology

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We report a case of nodular fasciitis (NF) of the breast, which was cytologically diagnosed as a spindle cell proliferation with undetermined malignant potential. Owing to small size of the lesion (5.9 × 3.7 × 4.1 mm), only fine needle aspiration (FNA) cytology was performed under ultrasound guidance. The FNA smears were cellular, rich in single/clustered spindle cells but mammary ductal epithelial/myoepithelial cells were absent. These cytologic findings suggested spindle cell growth of mesenchymal origin. Pattern-less arrangement of spindle cells, heterogeneous composition of the stromal matrix, lack of nuclear/cellular atypia, occasional mitosis but no aberrant mitotic figures, and lymphocyte infiltration indicated reactive rather than neoplastic nature of the lesion. Nonetheless, lumpectomy was conducted because the possibility of neoplasm was not completely ruled out. The histologic diagnosis of the resected nodule was NF. FNA specimens were reviewed thoroughly in an attempt to define the key cytomorphologic features of NF that are important for the correct diagnosis. Differential diagnoses from the lesions that show similar cytologic pictures are discussed in detail. Although NF arising from the breast is rare, cytopathologists should be aware of its clinical and cytopathologic characteristics. Knowledge of the possibility of NF in the breast and its cytologic findings may help cytopathologists to discern its reactive, not neoplastic, characteristics of the lesion. If the referring surgeon is alerted NF as a possibility along with other differential diagnoses, close observation would become a management option. In-depth discussion of cytologic features and a review of the pertinent literature are also included.

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