Fine Needle Aspiration Cytology of Langerhans Cell Histiocytosis of Mandible - A Case Report -

Abstract

We present a case of mandibular involvement with Langerhans cell histiocytosis (LCH), diagnosed by ultrasound-guided aspiration and subsequently confirmed by incisional biopsy and immunohistochemistry in an eight-year-old boy. The cytologic findings included the presence of characteristic Langerhans cells of both mononucleate and multinucleate form. Diagnostic confirmation was obtained by immunopositivity for S-100 protein and CD1a of Langerhans histiocytes on paraffin-embedded sections obtained during incisional biopsy of the right mandibular area. By reporting a case of childhood LCH, we correlate the cytologic findings with histologic features and discuss the role of aspiration cytologic diagnosis in such a rare and cytomorphologically characteristic case.

Bronchial Washing Cytology of Pulmonary Langerhans Cell Histiocytosis: A Case Report

“…Lee et al . [ 5 ] reported a case of LCH in the mandible diagnosed with fine needle aspiration cytology and indicated that the smear revealed high cellularity, and that the LCs had abundant vacuolated cytoplasm with round or occasionally folded nuclei. The LC nuclei showed a fine granular chromatin pattern with prominent nucleoli.…”

“…[ 6 ] reported a case of LCH in lymph nodes using aspiration cytology similar to the case reported by Lee et al . [ 5 ]. In their study, the LCs had wrinkled or grooved nuclei with thin nuclear membranes and a delicate chromatin pattern.…”