Fine‐needle aspiration cytology of columnar‐cell carcinoma of the thyroid: Report of two cases with cytohistologic correlation

Pérez, Ferràn; Llobet, Montserrat; Garijo, Gloria; Barceló, C.; Castro, Pilar; Bernadó, Luis

doi:10.1002/(sici)1097-0339(199805)18:5<352::aid-dc10>3.3.co;2-0

Cited by 4 publications

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“…CCV is one of the least common variants of PTC and is seen more frequently in male patients with a median age of 55 years. Patients with the CCV present with a high frequency of lymph node and distant metastases …”

Section: Aggressive Variants Of Ptcmentioning

confidence: 99%

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Cytologic features of aggressive variants of follicular‐derived thyroid carcinoma

Rossi

Faquin

Pantanowitz

2019

Cancer Cytopathology

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Certain carcinomas of the thyroid gland behave aggressively resulting in increased patient morbidity and poor patient prognosis. The diagnosis of these aggressive thyroid cancer subtypes is sometimes challenging and subject to increased interobserver variability. This review deals with the cytological features of such tumors including aggressive variants of papillary thyroid carcinoma, poorly differentiated thyroid carcinoma, and anaplastic thyroid carcinoma. These malignancies fall into 2 groups based on their cytomorphology: those that exhibit distinct microscopic features (eg, nuclear findings typical of classical papillary thyroid carcinoma or marked anaplasia) and those that present with more subtle cytologic features (eg, nuclear pseudostratification, “soap bubble” nuclei, supranuclear or subnuclear cytoplasmic vacuoles, rosette‐like structures, hobnail cells). We review the literature regarding these aggressive thyroid cancers and highlight important phenotypic characteristics that can be useful for their diagnosis based on fine needle aspiration.

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Section: Aggressive Variants Of Ptcmentioning

confidence: 99%

“…Although infrequently described, the cytological features of CCV include columnar cells with hyperchromatic, oval, and pseudostratified nuclei with supranuclear or subnuclear cytoplasmic vacuoles . Nuclei have dark stippled chromatin and indistinct nucleoli.…”

Section: Aggressive Variants Of Ptcmentioning

confidence: 99%

Cytologic features of aggressive variants of follicular‐derived thyroid carcinoma

Rossi

Faquin

Pantanowitz

2019

Cancer Cytopathology

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“…Intranuclear inclusions and nuclear grooves are uncommon in FNA smears (Fig. ) . The nuclei are larger than normal follicular epithelium nuclei, and the cytoplasm is not particularly abundant but may exhibit focal vacuolation .…”

Section: Introductionmentioning

confidence: 99%

“…In FNA samples, CCV‐PTC usually yields a moderately cellular specimen with cells arranged in loosely cohesive papillary clusters, monolayer sheets, rosette‐like microfollicles, and acinar patterns within a background devoid of colloid . Syncytial‐type cell aggregates with poorly defined cell borders and indistinct cytoplasm can also be observed . The cells are usually large, and the nuclei are oval or elongated with powdery chromatin and inconspicuous nucleoli.…”

Section: Introductionmentioning

confidence: 99%

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Aggressive variants of follicular cell‐derived thyroid carcinomas: A cytopathologist's perspective

Lastra

LiVolsi

Baloch

2014

Cancer Cytopathology

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Follicular cell-derived carcinomas of the thyroid gland comprise a heterogeneous group of malignant neoplasms of the thyroid gland with varied histologic appearance and molecular profiles. In most patients, these tumors represent relatively indolent neoplasms; however, certain subtypes/variants behave in an aggressive manner, and the recognition of this subset of tumors is essential because of their variable response to therapy and significant morbidity and mortality.Fine-needle aspiration is considered an essential tool for the diagnosis of suspicious thyroid nodules. In this review, the authors discuss the clinical, histologic, and molecular findings and the prognostic implications of aggressive thyroid neoplasms with emphasis on the characteristic cytomorphologic features on fine-needle aspiration smears. Cancer KEY WORDS: thyroid; carcinoma; aggressive; follicular; fine-needle aspiration; cytology. INTRODUCTIONThe incidence of cancers originating in the thyroid gland has been steadily increasing over the past 20 years. It is estimated that 60,220 new thyroid cancers cases and 1850 thyroid cancer-related deaths will occur in the United States in 2013; of these, 45,310 will occur in women.1 These statistics place thyroid cancer as the fifth most common cancer among women.1 Currently, thyroid carcinomas are broadly categorized as well differentiated, poorly differentiated, and anaplastic carcinoma. 2 Other than C-cell-derived medullary thyroid carcinoma, all of these tumors originate from thyroid follicular cells. The category of well differentiated thyroid carcinomas includes papillary, follicular, and medullary carcinomas. Follicular thyroid carcinoma and papillary thyroid carcinoma (PTC) are considered relatively indolent malignancies, with a 5-year and 10-year survival rates of 97.5% and >90%, respectively. 3,4 It is now well known, however, that certain histologic subtypes of thyroid carcinomas behave in a more aggressive fashion, and these tumors are recognized as aggressive variants by the World Health Organization (WHO). 4Today, fine-needle aspiration (FNA) biopsy of the thyroid is a widely used technique for obtaining tissue for the diagnosis of clinically or radiologically suspicious nodules.5 However, there is a paucity of reports describing the cytomorphologic features of aggressive variants of thyroid carcinomas. Although some of these tumors present with the characteristic nuclear features of PTC and are relatively easily diagnosed as such, the Review Article lack of these features in certain variants of PTC might lead to these being underdiagnosed as "suspicious for follicular neoplasm." The clinical implications and surgical management of these diagnoses vary significantly, because cases diagnosed as PTC have a malignancy rate upon resection of >90%, and those diagnosed as "suspicious for follicular neoplasm" are identified as malignant upon resection in only 15% to 30% of cases. Hence, FNA cases diagnosed as PTC generally undergo total thyroidectomy, and cases diagnosed as "suspicious for folli...

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Columnar cell variant of papillary thyroid carcinoma: A diagnostic dilemma in fine‐needle aspiration cytology

Verma

Paul

2016

Diagnostic Cytopathology

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Columnar cell variant of papillary thyroid carcinoma (PTC) is an uncommon variant with an aggressive course as compared to classic papillary carcinoma. Cytologic diagnosis of these tumors is difficult due to absence of characteristic nuclear features of classic pattern of papillary carcinoma. We present a case of columnar cell variant in a young female misdiagnosed on aspiration cytology. A 21-year-old female presented with solitary nodule in the left aspect of thyroid. A diagnosis of medullary thyroid carcinoma was rendered. The resected thyoroidectomy specimen revealed a columnar cell variant of PTC which was further supported by immunohistochemical staining. Diagn. Cytopathol. 2016;44:816-819. © 2016 Wiley Periodicals, Inc.

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Fine‐needle aspiration cytology of columnar‐cell carcinoma of the thyroid: Report of two cases with cytohistologic correlation

Cited by 4 publications

References 0 publications

Cytologic features of aggressive variants of follicular‐derived thyroid carcinoma

Cytologic features of aggressive variants of follicular‐derived thyroid carcinoma

Aggressive variants of follicular cell‐derived thyroid carcinomas: A cytopathologist's perspective

Columnar cell variant of papillary thyroid carcinoma: A diagnostic dilemma in fine‐needle aspiration cytology

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