Fine-Needle Aspiration Cytology of Disseminated Kaposi Sarcoma of the Bone in an AIDS Patient

Yergiyev, Oleksandr; Mohanty, Aprajita; Curran-Melendez, Sheilah M.; Latona, Carmen R.; Bhagavatula, Rama; Greenberg, Larisa; Silverman, Jan F.

doi:10.1159/000369855

Cited by 5 publications

(4 citation statements)

References 4 publications

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“…Extravasated red blood cells can be seen. The cells usually have indistinct cytoplasmic borders and elongated nuclei with even chromatin and focal small nucleoli 6,7 …”

Section: Discussionmentioning

confidence: 99%

“…The cells usually have indistinct cytoplasmic borders and elongated nuclei with even chromatin and focal small nucleoli. 6,7 The differential diagnosis of KS varies significantly based on the location of the lesion. In soft tissue, diagnostic consideration is primarily between spindle cell melanoma, KS, and other vascular neoplasms KS in the differential diagnosis, especially in immunocompromised patients.…”

Section: Discussionmentioning

confidence: 99%

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Pulmonary Kaposi sarcoma in a patient with bilateral lung transplant: An unexpected diagnosis on transbronchial fine needle aspiration and core biopsy

Trabzonlu,

McDermott,

Pitman

et al. 2024

Diagnostic Cytopathology

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Kaposi sarcoma (KS) is a low‐grade vascular neoplasm that can be seen in various sites, most commonly seen in skin and mucosal tissues. Cytologic features of KS have been well‐documented in the literature, however, since it is rarely seen in visceral organs, it could pose significant diagnostic challenges on fine needle aspiration (FNA) biopsies. We present a case of pulmonary KS diagnosed on transbronchial FNA biopsy in a 70‐year‐old female bilateral lung allograft recipient 11 months after transplantation. The aspirate smears showed a moderately cellular specimen containing a mixture of small, tightly cohesive clusters and loosely clustered groups of monomorphic, ovoid to spindled cells with moderate nuclear to cytoplasmic ratio. An extensive immunohistochemical panel on the concurrent core biopsy showed the tumor cells to be positive for ERG, KIT, and HHV8, confirming the diagnosis. We compared our case to previously published reports of confirmed pulmonary KS in lung allograft recipients.

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“…Extravasated red blood cells can be seen. The cells usually have indistinct cytoplasmic borders and elongated nuclei with even chromatin and focal small nucleoli 6,7 …”

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Pulmonary Kaposi sarcoma in a patient with bilateral lung transplant: An unexpected diagnosis on transbronchial fine needle aspiration and core biopsy

Trabzonlu,

McDermott,

Pitman

et al. 2024

Diagnostic Cytopathology

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“…Саркома Капоши -это мультицентрическая опухоль сосудистого происхождения низкой степени злокачественности с преимущественным поражением кожи, а также внутренних органов и лимфатических узлов. На сегодняшний день принято считать, что причиной развития опухоли является γ-вирус герпеса 8-го типа (HHV8) [1,2].…”

Section: Introductionunclassified

“…

ВведениеСаркома Капоши -это мультицентрическая опухоль сосудистого происхождения низкой степени злокачественности с преимущественным поражением кожи, а также внутренних органов и лимфатических узлов. На сегодняшний день принято считать, что причиной развития опухоли является γ-вирус герпеса 8-го типа (HHV8) [1,2].В развитых странах среди пациентов, инфицированных вирусом иммунодефицита человека (ВИЧ), частота выявления HHV8 наиболее высока у гомо-и бисексуальных мужчин. Саркома Капоши у них является самой распространенной опухолью, ассоциированной с синдромом приобретенного иммунодефицита (СПИД), частота ее составляет 20% [2].По данным Globacan, в 2020 г. в мире зарегистрировано 34 270 новых случаев саркомы Капоши.

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Disseminated Kaposi sarcoma with osseous metastases in patients with HIV infection. Case report

Огнерубов

Antipova²

2021

J. Mod. Onco.

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Background. Kaposi sarcoma is a low-grade vascular tumor affecting blood and lymphatic vessels associated with the human herpes virus type 8 (HHV-8). As a rule, the skin of the lower extremities is involved in the process first of all, and then other organs and lymph nodes are involved. There are 4 various types of the disease with different clinical picture: the classic, the endemic, the epidemic and immunosuppression subtype. The epidemic subtype is the most common and has the most aggressive course, with specific lesions of a multiple kind, including the skin, mucous membrane layers, the lymph nodes, the gastrointestinal tract, the lungs and the spleen. Osseous metastases are extremely rare. Aim. Show the case of Kaposi sarcoma with osseous metastases in patient with the human immunodeficiency virus (HIV) infection. Results. We observed a 43-year-old patient with HIV infection and stage 4b Kaposi sarcoma against the background of the irregular antiretroviral therapy in the progression stages. The duration of the anamnesis was 32 months. The clinical debut of the cancer process was noted with skin lesions on the shoulder. Histological and immunohistochemical analysis of skin biopsies showed the morphological picture of Kaposi sarcoma. HHV-8 was expressed in tumor cells. During the endoscopic examination the lesions of oral mucosa, stomach and proximal colon were confirmed morphologically, and spiral computed tomography of the chest revealed the lesions in the lungs. On this point, the patients received oxaliplatin-based chemotherapy and aetoposidum for 6 months and against the background of this treatment we observed the disease progression associated with the involvement of the retroperitoneal lymph nodes, the left adrenal gland and the penis. Circumcision was performed in the case associated with the involvement of the penis. The treatment was continued. The lytic left iliac bone lesion, the retroperitoneal lymph nodes, the iliac lymph node groups, as well as the left inguinal lymph nodes, the left adrenal gland and the lungs were characterized by a high F-18 FDG uptake after 3 months of the treatment, according to the results of Fluorine-18 fluorodeoxyglucose (F-18 FDG) positron emission tomography combined with computed tomography (PET/CT). Conclusion. Kaposi sarcoma in patients with HIV infection had an aggressively course with disseminated skin lesions and internal organ involvement, including bones as showed in this clinical case. In this case, the axial skeleton was more commonly involved. PET/CT is a diagnostic imaging method in the differential diagnosis and determination of the prevalence of the cancer process.

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Kaposi sarcoma in an HIV-negative Tunisian patient: A rare cause of metatarsalgia

Tekaya

Mahmoud

et al. 2017

The Egyptian Rheumatologist

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Fine-Needle Aspiration Cytology of Disseminated Kaposi Sarcoma of the Bone in an AIDS Patient

Cited by 5 publications

References 4 publications

Pulmonary Kaposi sarcoma in a patient with bilateral lung transplant: An unexpected diagnosis on transbronchial fine needle aspiration and core biopsy

Pulmonary Kaposi sarcoma in a patient with bilateral lung transplant: An unexpected diagnosis on transbronchial fine needle aspiration and core biopsy

Disseminated Kaposi sarcoma with osseous metastases in patients with HIV infection. Case report

Kaposi sarcoma in an HIV-negative Tunisian patient: A rare cause of metatarsalgia

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