Fine Needle Aspiration Cytology of Metastatic Olfactory Neuroblastoma

Chung, Jae Hyun; Park, Seon Tae; Jang, Jaejung

doi:10.1159/000326714

Cited by 12 publications

(8 citation statements)

References 9 publications

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“…All made note of rosettes and fibrillary material (variably described as "elongated cytoplasm," "thin cytoplasmic processes," "fibrillary stroma," "fibrillary cytoplasm," "carrot-like cytoplasm," "fibrillary matrix," and "fibrillary cytoplasm"). [9][10][11][12][13][14][15][16] Two cases were originally diagnosed as "undifferentiated carcinoma" and "adenocarcinoma." 9,12 In 1 case, the diagnosis of ONB was made prospectively without the benefit of previous surgical biopsy diagnosis (in a patient presenting with cervical lymphadenopathy).…”

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confidence: 99%

The Cytologic Features of Sinonasal Undifferentiated Carcinoma and Olfactory Neuroblastoma

Bellizzi¹,

Bourne²,

Mills³

et al. 2008

Am J Clin Pathol

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Sinonasal undifferentiated carcinoma (SNUC) is a rare, aggressive malignancy of the sinonasal tract. Olfactory neuroblastoma (ONB) is an uncommon neuroectodermal tumor of the superior nasal cavity. Upon examining these lesions, a broad differential diagnosis of poorly differentiated round cell tumors must be considered. The cytologic features of SNUC and ONB have been rarely reported. We searched our cytology files for cases of SNUC and ONB and assessed the following: cellularity, architecture, cytoplasm, cell size, nuclear contours, nucleoli, chromatin, anisonucleosis/anisocytosis, mitotic activity, background, and nuclear crush. Seven cases of SNUC produced hypercellular smears with a single-cell-predominant pattern. Cells were intermediate-sized with irregular nuclear contours and small nucleoli. Nuclear crush and mitotic figures were noted. The background exhibited naked nuclei and karyorrhectic debris. Of 7 cases, 6 (86%) exhibited vacuoles or extracellular lumina. The 10 cases of ONB exhibited cellularity, cellular arrangement, and chromatin similar to SNUC. In contrast, ONBs demonstrated fibrillary cytoplasm and smooth nuclear contours; mitotic figures were generally absent. Homer Wright rosettes were encountered in 9 cases (90%). We believe that in the appropriate clinical context, a specific cytologic diagnosis should be possible.

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confidence: 99%

The Cytologic Features of Sinonasal Undifferentiated Carcinoma and Olfactory Neuroblastoma

Bellizzi¹,

Bourne²,

Mills³

et al. 2008

Am J Clin Pathol

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“…Olfactory neuroblastoma is a rare neoplasm of neuroectodermal origin comprising 1%‐5% of nasal cavity neoplasms . Sixty‐five percent of olfactory neuroblastoma patients reported in the cytology literature had a diagnosis rendered from either a soft‐tissue swelling or a lymph node of the neck region, indicating a predilection for locoregional spread. However, metastases to distant sites have also been reported, and cytologic exam has been employed to identify metastatic olfactory neuroblastoma in loci such as pleural fluid, scalp, liver, spine, and parotid .…”

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confidence: 99%

Metastatic neoplasms to the pancreas diagnosed by fine‐needle aspiration/biopsy cytology: A 15‐year retrospective analysis

Raymond

Yugawa

Chang

et al. 2017

Diagnostic Cytopathology

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Cytologic diagnosis of metastasis to the pancreas is rare in our institution, comprising only 2.5% and 7.2% of total and malignant pancreatic FNA/CNB, respectively. FNA/CNB with ROSE proved to be an effective diagnostic modality, thereby obviating the need for more invasive procedures in the setting of pancreatic metastases. EUS-FNA was equally effective as CT-guided biopsies in achieving specimen adequacy and definitive diagnoses. We also present the first known case of a metastatic olfactory neuroblastoma to the pancreas diagnosed by imprint cytology.

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“…To date, eighteen cases have been reported, the majority of them being scrapings or FNA of primary tumors or head and neck lymph nodes. [162122] Only one case of ENB metastatic to the right parietal scalp was reported in the largest series by Mahooti and Walker. [16]…”

Section: Discussionmentioning

confidence: 99%

Fine needle aspiration cytology of primary sphenoid sinus esthesioneuroblastoma metastatic to the skin

et al. 2012

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Esthesioneuroblastoma (ENB) is a rare tumor derived from olfactory neuroepithelium. ENB in a site outside of where olfactory epithelium exists is exceedingly rare with only five cases of ENB isolated to the sphenoid sinuses described in the literature to date. To the best of our knowledge, a skin metastasis of ENB outside the head and neck region has not been reported. We present an unusual case of a 33-year-old male diagnosed with primary sphenoid sinus ENB, who underwent surgical resection of the tumor followed by chemoradiation. About 5 months later, the patient developed a dermal mass in the sternal region, clinically suspicious for metastasis. Fine needle aspiration (FNA) revealed a tumor with morphological features and immunophenotype consistent with the metastasis from patient's known primary sphenoid sinus ENB. Our case demonstrates that the skin may be a rare site of a metastatic ENB, and FNA is a cost-effective and reliable diagnostic method of a suspected cutaneous metastasis.

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Fine Needle Aspiration Cytology of Metastatic Olfactory Neuroblastoma

Cited by 12 publications

References 9 publications

The Cytologic Features of Sinonasal Undifferentiated Carcinoma and Olfactory Neuroblastoma

The Cytologic Features of Sinonasal Undifferentiated Carcinoma and Olfactory Neuroblastoma

Metastatic neoplasms to the pancreas diagnosed by fine‐needle aspiration/biopsy cytology: A 15‐year retrospective analysis

Fine needle aspiration cytology of primary sphenoid sinus esthesioneuroblastoma metastatic to the skin

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