Fine Needle Aspiration Cytology of a Primary Malignant Peripheral Nerve Sheath Tumor Arising in the Parotid Gland

Nepka, Charitini; Karadana, Maria; Karasavvidou, Foteini; Barbanis, Sotirios; Kalodimos, Georgios; Koukoulis, Georgios

doi:10.1159/000325344

Cited by 9 publications

(11 citation statements)

References 15 publications

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“…Cobb et al, 2 from the United States, highlight the pitfalls in diagnosing Warthin's tumor, a distinctive entity but sometimes presenting with extensive necrosis or squamous metaplasia thus creating a pitfall. The case presented by Nepka et al, 3 from Greece, details how morphologic changes suggestive of peripheral nerve sheath tumor supported by immunocytochemical studies are helpful in the diagnosis of this uncommon tumor. Siddaraju et al 4 from India describe a rare case of pleomorphic adenoma with extensive lipometaplasia, Daneshbod and Khademi 5,6 from Iran describe a rare case of hydatid disease of the submandibular gland and also an intraductal papilloma of the parotid gland.…”

Section: Editorialmentioning

confidence: 99%

Fine Needle Aspiration of Salivary Glands

Bibbo¹

2009

Acta Cytologica

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Section: Editorialmentioning

confidence: 99%

Fine Needle Aspiration of Salivary Glands

Bibbo¹

2009

Acta Cytologica

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“…Surgical resection usually yields excellent results in the management of these lesions [13,22,24] MPNST arising from the parotid gland have presented as both tender [6,7,[9][10][11] and non-tender [3][4][5]8] masses which have grown slowly over the course of 3-12 months, but can progress in a more accelerated time frame [6]. Of the 9 cases within the literature, only one has shown facial nerve palsy at the time of presentation [6].…”

Section: Accepted Manuscriptmentioning

confidence: 99%

“…A single institution retrospective analysis by Cho et al found that neurofibromas and schwannoma comprised 0.2% (n=1) and 1.1% (n=6) respectively of 527 mesenchymal tumors found in salivary glands [1]. Of the 22 neurofibromas [2], 9 [3][4][5][6][7][8][9][10][11] MPSNT, and approximately 150 schwannomas [12][13][14][15][16][17][18][19][20][21][22] in the literature that have been found to arise in the salivary gland, the vast majority have been reported as single case reports or small series [13].…”

Section: Introductionmentioning

confidence: 99%

Peripheral nerve sheath tumors arising in salivary glands: A clinicopathologic study

Guraya

Prayson

2016

Annals of Diagnostic Pathology

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“…Cytology aspirate smears of MPNST are typically hypercellular with a combination of cohesive cell clusters of variable size and cellularity together with numerous single tumor cells and naked nuclei [ 94 , 95 ]. A fascicular pattern may be encountered in some cell clusters, though is not universally present; storiform or whorled patterns may also be encountered [ 30 ]. A fi brillary background may be present [ 95 ].…”

Section: Gross and Microscopic Features Mpnstmentioning

confidence: 99%

“…Nuclear pleomorphism is a frequent fi nding, as are mitotic fi gures (including atypical forms) [ 30 , 95 ]. A "dirty" necrotic background material may be seen [ 30 ].…”

Section: Gross and Microscopic Features Mpnstmentioning

confidence: 99%

Malignant Tumors of Peripheral Nerves

Kao

Parham

Fuller

2014

Pediatric Malignancies: Pathology and Imaging

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Malignant peripheral nerve sheath tumors (MPNST) represent a group of malignant spindle cell sarcomas with evidence of nerve sheath differentiation and/or arising from a peripheral nerve. Tumors showing origin from epineurial connective tissue or vascular structures are not considered to represent MPNST. Older/prior terminology for MPNST includes malignant neurilemmoma, malignant schwannoma, neurofi brosarcoma, and neurogenic sarcoma [ 1 ]. A number of histologic subtypes have been described. The majority are high grade aggressive sarcomas that show a strong tendency for local recurrence and metastases despite aggressive therapeutic measures [ 2 ]. Clinical Features and EpidemiologyThere is a strong association between MPNST and Neurofi bromatosis Type 1 (NF1), with 50 % of all MPNSTs arising within this patient population [ 3 ]. Approximately 10 % of individuals with NF1 will develop an MPNST over their lifetime, most of these tumors representing malignant degeneration occurring within preexisting plexiform neurofi bromas. One study of 476 NF1 patients documented a strong association between the presence of subcutaneous neurofi bromas and internal plexiform neurofi bromas, with an even stronger correlation between the presence of internal plexiform neurofi bromas and MPNST [ 4 ]. The remainder of MPNSTs will arise de novo, approximately 5-10 % representing radiation-induced sarcomas [ 1 ]. There is no particular gender predilection, and MPNSTs have been documented throughout a wide age range including children and the elderly. The majority however tend to present in adults with a median age in the mid 40s [ 5 ]. MPNSTs arising in the NF1 population tend to present up to a decade earlier, and these patients' tumors also tend to be larger [ 3 , 6 ].The majority of MPNST arise from larger peripheral nerves or within deep soft tissues, the most frequent sites including brachial plexus, sciatic, and paraspinal nerves, proximal upper and lower extremities, and buttock regions [ 5 ]. They have also been documented in a wide variety of locations throughout the body. Well over 50 cases of spinal MPNST have been reported [ 7 -13 ]. No particular spinal level is preferentially involved, and interestingly a significant proportion of spinal MPNST exhibit rhabdomyoblastic elements (Malignant Triton Tumor; see histologic description below) [ 14 -17 ]. MPNST represents one of the most aggressive tumors that may involve structures of the head and neck region [ 6 ]. It may arise from cranial nerves, particularly the vestibular [ 18 ], vagus [ 18 ], facial [ 18 , 19 ], and trigeminal [ 19 , 20 ]. Other sites include not only brachial plexus [ 21 ], but also scalp and bony structures (base of skull [ 22 -25 ], sinuses [ 26 , 27 ], and bones of the jaw) [ 28 , 29 ]

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Fine Needle Aspiration Cytology of a Primary Malignant Peripheral Nerve Sheath Tumor Arising in the Parotid Gland

Cited by 9 publications

References 15 publications

Fine Needle Aspiration of Salivary Glands

Fine Needle Aspiration of Salivary Glands

Peripheral nerve sheath tumors arising in salivary glands: A clinicopathologic study

Malignant Tumors of Peripheral Nerves

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