Fine-needle aspiration cytology of metastatic clear-cell renal carcinoma presenting as a solitary mass in the head of the pancreas

Gupta, Raj K.; Lallu, Shardu; Delahunt, Brett

doi:10.1002/(sici)1097-0339(199809)19:3<194::aid-dc8>3.0.co;2-d

Cited by 13 publications

(2 citation statements)

References 22 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Data for individual patients were not provided in ten reports containing a total of 100 patients27, 29, 63, 68, 75, 113, 119, 122, 159, 176. Thirty‐eight publications described 86 patients who did not undergo surgery for pancreatic RCC metastases8, 27, 28, 30, 41, 55, 106, 118, 131, 132, 152, 173, 175–177, 179–201. One of these 38 reports did not provide individual data for a total of 13 patients176.…”

Section: Methodsmentioning

confidence: 99%

Enabling Bifunctionality and Hemilability of N‐Heteroaryl NHC Complexes

Specht

Cortés-Llamas

Tran

et al. 2011

Chemistry A European J

View full text Add to dashboard Cite

Background: This study examined the clinical outcome of patients with pancreatic metastases from renal cell carcinoma (RCC). Methods: A systematic literature search produced individual data for 311 surgically and 73 non‐surgically treated patients with pancreatic RCC metastases. A further ten patients underwent resection at the authors' institution. Results: In the resected group, pancreatic metastases were solitary in 65·3 per cent, symptomatic in 57·4 per cent, and were preceded and/or accompanied by extrapancreatic disease in 22·3 per cent. Respective values in the unresected group were 59, 60 and 58 per cent. Disease‐free survival rates were 76·0 and 57·0 per cent respectively at 2 and 5 years after resection, and overall survival rates were 80·6 and 72·6 per cent. The only significant risk factor for disease‐free survival after pancreatic resection was extrapancreatic disease (P = 0·001), and that for overall survival was symptomatic RCC metastasis (P = 0·031). Two‐ and 5‐year overall survival rates were 41 and 14 per cent respectively in unresected patients. Conclusion: The actuarial 5‐year overall survival rate following pancreatic surgery for RCC metastases was 72·6 per cent, as determined by pooled analysis from published series. Extrapancreatic disease was an independent risk factor for recurrence, but had no significant impact on overall survival. Copyright © 2009 British Journal of Surgery Society Ltd. Published by John Wiley & Sons, Ltd.

show abstract

Section: Methodsmentioning

confidence: 99%

Enabling Bifunctionality and Hemilability of N‐Heteroaryl NHC Complexes

Specht

Cortés-Llamas

Tran

et al. 2011

Chemistry A European J

View full text Add to dashboard Cite

show abstract

“…That only changed with the progress that was made in pancreas diagnostics, which allowed the more frequent diagnosing of these tumors: In 2006, our working group was able to find as many as 239 reports [24], and 666 by 2016 [25]. By the end of 2018, 148 additional reports were added, which increased the total to 814 reports [24,26,27,28,29,30,31,32,33,34,35,36,37,38,39,40,41,42,43,44,45,46,47,48,49,50,51,52,53,54,55,56,57,58,59,60,61,62,63,64,65,66,67,68,69,70,71,72,73,74,75,76,77,78,79,80,81,82,83,84,85,86,87,88,…”

Section: Resultsmentioning

confidence: 99%

Observations on Solitary Versus Multiple Isolated Pancreatic Metastases of Renal Cell Carcinoma: Another Indication of a Seed and Soil Mechanism?

Sellner¹

2019

Cancers

View full text Add to dashboard Cite

Isolated pancreas metastases are a rare type of metastasis of renal cell carcinoma, characterized by the presence of pancreatic metastases, while all other organs remain unaffected. In a previous study, we determined arguments from the literature which (a) indicate a systemic–haematogenic metastasis route (uniform distribution of the metastases across the pancreas and independence of the metastatic localization in the pancreas of the side of the renal carcinoma); and (b) postulate a high impact of a seed and soil mechanism (SSM) on isolated pancreatic metastasis of renal cell carcinoma (isPM) as an explanation for exclusive pancreatic metastases, despite a systemic haematogenous tumor cell embolization. The objective of the study presented was to search for further arguments in favor of an SSM with isPM. For that purpose, the factor’s histology, grading, and singular/multiple pancreas metastases were analyzed on the basis of 814 observations published up to 2018. While histology and grading allowed for no conclusions regarding the importance of an SSM, the comparison of singular/multiple pancreas metastases produced arguments in favor of an SSM: 1. The multiple pancreas metastases observed in 38.1% prove that multiple tumor cell embolisms occur with isPM, the exclusive “maturation” of which in the pancreas requires an SSM; 2. The survival rates (SVR), which are consistent with singular and multiple pancreas metastases (despite the higher total tumor load with the latter), prove that the metastasized tumor cells are not able to survive in all other organs because of an SSM, which results in identical SVR when the pancreatic foci are treated adequately.

show abstract