Fine‐needle aspiration cytology of orbital meningiomas

Agrawal, Pallavi; Dey, Pranab; Saikia, Uma Nahar; Gupta, Nalini; Srinivasan, Radhika; Nijhawan, Raje; Rajwanshi, Arvind

doi:10.1002/dc.21692

Cited by 10 publications

(14 citation statements)

References 9 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…To date, the cytomorphology of extracranial meningiomas has been reported predominantly via case reports in the literature [9,10,11,12,13,14,15,16,17,19,20,21,23,24,25,26,27,28]. To the best of our knowledge, this study represents the largest series detailing the cytomorphology of such tumors.…”

Section: Discussionmentioning

confidence: 94%

“…Previously published case reports of metastatic and primary ectopic meningiomas described tumors with typical low-grade cytomorphology [9,10,11,12,13,14,15,16,17,19,20,21,23,24,25,26,27,28]. In our study most cytology samples, particularly those from ectopic tumors, also revealed typical morphological features characteristic of low-grade intracranial meningiomas such as spindle-shaped tumor cells, whorls (concentric spheres of tumors cells), intranuclear pseudoinclusions, nuclear grooves and psammoma bodies [2].…”

Section: Discussionmentioning

confidence: 99%

“…Although the cytomorphology of squashed intracranial meningiomas have been well described for intraoperative neuropathology consultations involving these tumors [1,8], the cytological findings of extracranial meningiomas have been limited to case reports. Primary ectopic meningiomas diagnosed by fine-needle aspiration (FNA) have been reported in the head and neck [9,10,11,12,13,14], orbit [15,16,17,18], bone [19], skin [20] and lung [21,22]. Metastatic meningiomas diagnosed by FNA have been documented in the lung [11,23,24,25,26], liver [27] and soft tissues [28].…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Cytopathology of Extracranial Ectopic and Metastatic Meningiomas

et al. 2013

View full text Add to dashboard Cite

Introduction: Extracranial meningiomas may infrequently be encountered as ectopic or metastatic tumors. Their rarity and unique cytomorphology often pose significant diagnostic dilemmas. The aim of this study was to report our experience with a series of ectopic and metastatic meningiomas, characterizing their cytomorphology with histological correlation. Materials and Methods: A retrospective analysis involving 13 patients with cytological preparations from extracranial meningiomas was performed. Cytology cases were correlated with available surgical resection specimens. Data regarding clinical findings, tumor information, cytomorphology, follow-up histological features and immunohistochemistry were recorded and analyzed. Results: There were 5 cases with metastases and 8 ectopic meningiomas. Metastases occurred in the scalp/skull, lung, paraspinal soft tissue and liver. Primary ectopic meningiomas were located in the paranasal sinuses and ear, orbit and neck. Cytomorphological features characteristic of meningiomas were identified in the majority of samples including tightly cohesive clusters of spindled cells, whorls, intranuclear inclusions, nuclear grooves and psammomatous calcification. Unusual cytomorphological features identified in only a few cases included epithelioid cell predominance, abundant inflammatory cells, small-cell change, papillary structures and pseudoacinar growth. Metastatic tumors exhibited more nuclear atypia and occasionally mitoses or necrosis. Meningiomas were shown to be immunoreactive for epithelial membrane antigen, pancytokeratin and vimentin. Conclusion: Although rare, extracranial meningiomas can be encountered in cytologic specimens and should be included in the differential diagnosis when characteristic morphological features of meningiomas are seen. Cytopathologists should be aware that these lesions could be mistaken for other tumors, especially when confounded by atypia and unusual cytomorphological features.

show abstract

Section: Discussionmentioning

confidence: 94%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Cytopathology of Extracranial Ectopic and Metastatic Meningiomas

et al. 2013

View full text Add to dashboard Cite

show abstract

“…Patients usually present with proptosis and diminution of vision. The smears show multiple whorls of meningothelial cells sometimes with intranuclear inclusions and psammomatous calcification …”

Section: Malignant Neoplasm Of Eyelidmentioning

confidence: 99%

Fine‐needle aspiration cytology of orbital and eyelid lesions

Agrawal

Dey

Lal

2013

Diagnostic Cytopathology

Self Cite

View full text Add to dashboard Cite

Fine-needle aspiration cytology (FNAC) of orbital lesions is now increasingly popular. Because of its unique location and the occurrence of varieties of lesions, diagnosis of orbital lesion is a challenge to the cytopathologists. FNAC of orbital and eyelid tumors is a suitable diagnostic technique that necessitates close co-operation between the ophthalmologist and pathologist. No radical procedure should be planned on the basis of FNAC, but it allows the diagnosis of a new primary lesion or the recurrence or metastasis of a tumor and can be done to identify lesions that require either specific medical therapy, as in nonresectable, inflammatory, and lymphoid tumors, or limited surgery for benign resectable neoplasms. With the help of various ancillary techniques a definitive diagnosis is possible on orbital and adnexal lesions. It is essential to have a detailed knowledge on the FNAC of these lesions and their potential pitfalls. In this present review, we have discussed various orbital lesions, their clinical presentations, cytomorphology, and ancillary techniques to confirm the diagnosis.

show abstract

“…[23] The smears of meningioma show multiple whorls of spindly meningothelial cells sometimes with intranuclear inclusions and psammomatous calcification. [24] The smears of neurofibroma and schwannoma show spindle cells having a wavy nucleus and a moderate amount of eosinophilic cytoplasm embedded in a fibrillary matrix.…”

Section: Discussionmentioning

confidence: 99%

Role of fine needle aspiration cytology as a diagnostic tool in orbital and adnexal lesions

Khan

Malukani

Malaiya

et al. 2016

J Ophthalmic Vis Res

View full text Add to dashboard Cite

Purpose:To evaluate the role of fine needle aspiration (FNAC) as a diagnostic tool in cases of orbital and ocular adnexal masses. Cytological findings were correlated with histopathological diagnosis wherever possible.Methods:FNAC was performed in 29 patients of different age groups presenting with orbital and ocular adnexal masses. Patients were evaluated clinically and investigated by non-invasive techniques before fine needle aspiration of the masses. Smears were analyzed by a cytologist in all cases. Further, results of cytology were compared with the histopathological diagnosis.Results:The age of patients ranged from 1 to 68 years (mean: 29.79±19.29). There were 14 males and 15 females with a male to female ratio of 0.93:1. Out of 29 cases, 26 aspirates were cellular. Cellularity was insufficient in three (10.34%) aspirates. Out of 26 cellular aspirates, 11 were non-neoplastic while 15 were neoplastic on cytology. Subsequent histopathologic examination was done in 21/26 cases. Concordance rate of FNAC in orbital and ocular adnexal mass lesions with respect to the precise histologic diagnosis was 90%.Conclusion:When properly used in well-indicated patients (in cases where a diagnosis cannot be made by clinical and imaging findings alone), FNAC of orbital and periorbital lesions is an invaluable and suitable adjunct diagnostic technique that necessitates close cooperation between the ophthalmologist and cytologist. However, nondiagnostic aspirates may sometimes be obtained, and an inconclusive FNAC should not always be ignored.

show abstract

Fine‐needle aspiration cytology of orbital meningiomas

Cited by 10 publications

References 9 publications

Cytopathology of Extracranial Ectopic and Metastatic Meningiomas

Cytopathology of Extracranial Ectopic and Metastatic Meningiomas

Fine‐needle aspiration cytology of orbital and eyelid lesions

Role of fine needle aspiration cytology as a diagnostic tool in orbital and adnexal lesions

Contact Info

Product

Resources

About