Fine-needle aspiration cytology of Rosai-Dorfman disease of the breast: A case report

Hummel, Pascale; Waisman, Jerry; Chhieng, David C.; Yan, Zi; Cohen, Jean‐Marc; Cangiarella, Joan

doi:10.1002/(sici)1097-0339(199910)21:4<287::aid-dc12>3.0.co;2-c

Cited by 28 publications

(9 citation statements)

References 12 publications

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“…Emperipolesis is characterized by the engulfment of lymphocytes, plasma cells, and neutrophils by histiocytes. In contrast with hemophagocytosis, where the ingested cells show various degrees of fragmentation and degeneration, in emperipolesis, the engulfed cells are not digested and appear intact, often surrounded by a prominent clear halo …”

Section: Discussionmentioning

confidence: 92%

Hemophagocytosis in an adrenal aspirate: Histiocytic sarcoma

Singh

Schmechel

Cioc

et al. 2013

Diagnostic Cytopathology

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Section: Discussionmentioning

confidence: 92%

Hemophagocytosis in an adrenal aspirate: Histiocytic sarcoma

Singh

Schmechel

Cioc

et al. 2013

Diagnostic Cytopathology

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“…To date there have been at least 26 indentified instances of RDD (2,4–21) in the breast, which were initially concerning for breast cancer. The cases include 24 women and two men.…”

Section: Discussionmentioning

confidence: 99%

Rosai-Dorfman Disease Presenting as a Breast Mass and Enlarged Axillary Lymph Node Mimicking Malignancy: A Case Report and Review of the Literature

Tenny¹,

McGinness

Zhang³

et al. 2011

The Breast Journal

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Rosai-Dorfman disease (also called sinus histiocytosis with massive lymphadenopathy) involves lymph nodes or lymph nodes with extranodal sites. We present a unique case of a patient presenting with a breast mass and axillary lymphadenopathy, mimicking malignancy clinically and radiographically. Core needle biopsies of the breast and axillary lymph node showed histologic features concerning the lymphoma. However, excisional biopsy specimen demonstrated characteristic features of Rosai-Dorfman disease. The disease recurred locally 6 months later in the same breast, 1 month later in the contralateral breast, and 11 month later in the subcutaneous tissue of left flank. A review of the literature of Rosai-Dorfman disease involving the breast is also presented.

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“…Immunohistochemical studies support the diagnosis [16]. Only a few of the reported cases of breast RDD were successfully diagnosed by ine needle aspiration biopsy and cytologic evaluation [7,8,[17][18][19]. Those diagnoses were based, primarily, on identi ication of the hallmark feature of emperipolesis.…”

Section: Discussion and Literature Reviewmentioning

confidence: 99%

Rosai-Dorfman disease presenting as a breast mass

Dai¹,

Cai²,

Vohra³

et al. 2019

Arch Pathol Clin Res

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Rosai-Dorfman disease (RDD) is an idiopathic, benign proliferation of histiocytes that can be present in multiple organs such as lymph node, skin, soft tissue, orbit, central nerve system and bone; however, it rarely occurs in the breast. In general, RDD is a painless, fi rm and poorly defi ned lesion, which can radiologically mimic a breast cancer and is therefore an important differential consideration. The diagnosis of breast RDD is challenging, especially on a small biopsy specimen. We report a unique case of breast RDD with a literature review including common presentation, differential diagnosis, and recommended management. A high index of suspicion for this rare entity is essential to render a correct diagnosis, thereby avoiding unnecessary diagnostic tests and treatment.How to cite this article: Dai D, Cai Q, Vohra NA, Wong J, Therien ZP, et al. Rosai-Dorfman disease presenting as a breast mass. Arch Pathol Clin Res. 2019; 3: 008-014. https://dx.

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Fine-needle aspiration cytology of Rosai-Dorfman disease of the breast: A case report

Cited by 28 publications

References 12 publications

Hemophagocytosis in an adrenal aspirate: Histiocytic sarcoma

Hemophagocytosis in an adrenal aspirate: Histiocytic sarcoma

Rosai-Dorfman Disease Presenting as a Breast Mass and Enlarged Axillary Lymph Node Mimicking Malignancy: A Case Report and Review of the Literature

Rosai-Dorfman disease presenting as a breast mass

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