Fine‐needle aspiration cytology of superficial angiomyxoma (myxoid perifollicular fibroma): Report of a case

Izquierdo, Francisco Miguel; Martin, L.; Burgos, Fernando; Lacruz, César R.

doi:10.1002/dc.2840130312

Cited by 9 publications

(7 citation statements)

References 3 publications

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“…10 In this case, a prominent number of neutrophils in the touch imprint smears as well as tissue sections were observed. Although Izquierdo et al 6 reported the cytologic features of SAMs of the breast, neutrophils were not mentioned and no literature has mentioned the cytologic differential diagnosis between SAMs and AAMs, the present authors suggest that a number of neutrophils with scattered stellate tumor cells in a myxoid background may help exclude other myxoid soft tissue tumors from SAMs based on the cytologic examination.…”

Section: Discussioncontrasting

confidence: 57%

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Giant superficial angiomyxoma of the vulva: a case report and review of the literature

Kim¹,

Kim²,

Lim³

et al. 2010

J Cutan Pathol

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Superficial angiomyxomas (SAMs) are rare, benign cutaneous tumors frequently involving the subcutis. Only 15 cases of SAM involving the vulva have been reported, ranging from 0.9 to 4 cm in diameter. A 26-year-old woman presented with a 7-year history of a large, pedunculated cutaneous mass on the left labium major, measuring 12.5 x 11 x 10.5 cm and mimicking a soft tissue sarcoma. The mass was relatively well-circumscribed, but unencapsulated and multilobulated. Microscopically, the mass showed a conglomerate of moderately-to-sparsely cellular angiomyxoid lobules. Each lobule consisted of scattered spindle-shaped or stellate tumor cells set in an abundant myxoid stroma. Thin-walled, small-to-medium-sized blood vessels were distributed diffusely throughout the stroma. Scattered stromal neutrophils were also observed. No large vessels or plexiform capillaries were apparent. There was no perivascular accentuation of stromal cells or smooth muscle bundles. The tumor cells constantly expressed vimentin, CD34, CD44 and S-100, but none expressed estrogen receptors (ERs) and progesterone receptors (PRs), desmin or cytokeratin. Together, these findings were diagnostic of a SAM. Giant SAMs of the vulva can mimic aggressive angiomyxomas (AAMs) and angiomyofibroblastomas (AMB), as well as soft tissue sarcomas. Giant SAMs should be included in the differential diagnosis of vulvar soft tissue tumors.

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Section: Discussioncontrasting

confidence: 57%

“…Furthermore, the cytologic appearance of a SAM has been reported in the English literature but one time. 6 Here, the authors discuss the histologic and cytologic features of SAMs useful for distinguishing this tumor from aggressive angiomyxomas (AAMs) and angiomyofibroblastomas (AMBs).…”

mentioning

confidence: 99%

Giant superficial angiomyxoma of the vulva: a case report and review of the literature

Kim¹,

Kim²,

Lim³

et al. 2010

J Cutan Pathol

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“…Literature on FNAC of myxoid lesions is principally related to soft tissue tumors. [ 8 9 ] To the best of our knowledge, there is a single case report of FNAC of superficial angiomyxoma[ 10 ] and we have not found any cytological study about cutaneous myxomas.…”

Section: Discussionmentioning

confidence: 98%

Cytologic diagnosis of unusual, large multiple cutaneous myxomas in a case of Carney complex

et al. 2018

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Cutaneous myxomas are rare benign neoplasms which are frequently associated with Carney complex (CNC). Although more than 500 cases of CNC are reported, there is no literature on cytologic diagnosis of Cutaneous myxomas. An 18-year-old male, with no significant family history, presented with multiple cutaneous swellings, largest measuring 15 cm on the right cheek. He also had spotty skin pigmentations, raised adrenocorticotropic hormone levels and recurrent cardiac myxomas. Fine-needle aspiration cytology from the right cheek and suprapubic swellings revealed paucicellular smears with abundant myxoid material in the background, admixed with fragments of spindle and stellate cells with bland nuclear morphology, and vascular proliferation in few fragments. There was no mitosis, necrosis, or any epithelial element. Hence, diagnosis of cutaneous myxomas in CNC was made which was confirmed on histopathology. This is the first report of cytologic diagnosis of multiple cutaneous myxomas in CNC and the largest cutaneous myxoma reported in literature.

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“…In cases without Carney complex, the occurrence of SAM on the breast is extremely rare. Only eight such cases have been reported (5,(7)(8)(9)(10)(11); 2 cases (25%) in males and 6 (75%) in females (all in premenopausal women); 4 cases (50.0%) on the nipple, 1 case (12.5%) in the nipple-areola complex, 2 case (25.0%) in the subcutaneous region and 1 case (12.5%) in the areola. A summary of the previously reported studies looking at SAM of the breast is listed in Table 1.…”

Section: Discussionmentioning

confidence: 99%

Superficial angiomyxoma of the breast in a 25-year-old woman without carney’s complex: case report and literature review

Meng

Yin

Chen

et al. 2022

Preprint

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Background: Superficial angiomyxoma (SAM) is a rare, benign tumor characterized by scattered stellate or spindle cells and thin-walled blood vessels embedded in abundant myxoid stroma. It was first reported as a cutaneous myxoma associated with Carney complex in 1985, and lesions are commonly located in the eyelids, external ear canal, and nipples and often appear in multiples. In cases with no evidence of Carney complex, the incidence of breast SAM is extremely rare. Case presentation: We reported a case of a 25-year-old Chinese woman presented with a left breast lump in the subareolar region for three years and gradually increased in size. No evidence of Carney complex was noted. Breast ultrasonography (US) and magnetic resonance imaging (MRI) were undertaken with US BI-RADS 4A and MR BI-RADS 4, respectively. The patient denied biopsy and underwent a lumpectomy and was diagnosed with SAM. There was no tumor recurrence after 18 months of follow-up. Conclusion: This case report suggests that the preoperative US and MRI characteristics of breast SAM are specific and in accordance well with the histological appearances. Recognition of these imaging features may be helpful for the diagnosis of SAM. And complete excision and long-time regular follow-up after surgery are recommended.

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Fine‐needle aspiration cytology of superficial angiomyxoma (myxoid perifollicular fibroma): Report of a case

Cited by 9 publications

References 3 publications

Giant superficial angiomyxoma of the vulva: a case report and review of the literature

Giant superficial angiomyxoma of the vulva: a case report and review of the literature

Cytologic diagnosis of unusual, large multiple cutaneous myxomas in a case of Carney complex

Superficial angiomyxoma of the breast in a 25-year-old woman without carney’s complex: case report and literature review

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