Fine Needle Aspiration in a Malignant Lymphoepithelial Lesion

Kanjanavirojkul, Nipa; Kularbkaew, Churairat; Yutanawiboonchai, Wiboonchai

doi:10.1159/000325526

Cited by 6 publications

(4 citation statements)

References 16 publications

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“…Although most case reports describe the cytological smears of LEC as moderately to highly cellular,[248] in the present case the lesion remained masked despite two FNA attempts due to scant cellularity. Jang et al .…”

Section: Discussionmentioning

confidence: 58%

“…[1] Primary LEC occurring in the salivary gland is extremely rare accounting for 0.4-1.0% of the epithelial tumors of the salivary gland. [2] This lesion displays a mysteriously strong racial predilection with the age at presentation ranging from 20 to 60 years and female to male ratio of 1.5:1. [13]…”

Section: Discussionmentioning

confidence: 99%

“…[124] The ratio of LEC of the parotid gland to submandibular gland in accumulated cases in literature is 17:1. [5] A strong association of LEC with EBV is noted.…”

Section: Discussionmentioning

confidence: 99%

“…[1] The parotid gland is involved in more than 90% of tumors, with the submandibular gland being an uncommon site. [2] A high proportion of these tumors show consistent association with Epstein-Barr virus (EBV). [1] Although a variant of undifferentiated carcinoma, the prognosis seems to be better than other undifferentiated carcinomas of salivary gland, probably because lymphoid stroma has a role in limiting the aggressiveness of this lesion.…”

Section: Introductionmentioning

confidence: 99%

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Cytomorphological features of lymphoepithelial carcinoma of submandibular gland in an adolescent male

Amit

Agarwal

Khan

2012

J Cytol

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A case of lymphoepithelial carcinoma (LEC) occurring in right submandibular gland of a 13-year-old Indian male is presented, wherein the lesion unveiled itself only after multiple fine needle aspiration (FNA) procedures. This unusual neoplasm has high frequency of occurrence in Eskimos and a predilection for the parotid gland. The aspirates obtained were highly cellular comprising tight clusters of atypical epithelial cells with admixture of lymphocytes. Histopathological examination of the resected submandibular gland and lymph node chain was consistent with the diagnosis of LEC. Immunohistochemistry (IHC) revealed cytokeratin (CK)-positive and S-100-negative tumor cells lying admixed with CD45-positive lymphoid cells. A detailed otorhinolaryngological examination with inclusion of multiple biopsies was found negative for any primary tumor. Although histopathological features of this entity are well established, only a handful of case reports describing cytological features of this entity are present in medical literature. We conclude that the cytomorphological features of LEC are sufficiently distinctive to at least, suggest a possibility of this lesion.

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Section: Discussionmentioning

confidence: 58%

Section: Discussionmentioning

confidence: 99%

“…[124] The ratio of LEC of the parotid gland to submandibular gland in accumulated cases in literature is 17:1. [5] A strong association of LEC with EBV is noted.…”

Section: Discussionmentioning

confidence: 99%