Fine‐needle aspiration of lipoblastoma: Cytological, molecular, and clinical features

Ferreira, Joana; Esteves, Gonçalo; Fonseca, Ricardo Roberto de Souza; Martins, Conceição; André, Saudade; Lemos, Maria Manuel

doi:10.1002/cncy.21916

Cited by 20 publications

(14 citation statements)

References 32 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Ultrasonography-guided FNA is a minimally invasive sampling technique. Many papers including case reports have shown its safety, clinical usefulness, and limitation for diagnosing retroperitoneal tumors such as schwannoma [25], lipoblastoma [26], histiocytic sarcoma [27], liposarcoma [28], and abscess. Most of them are not able to be diagnosed solely from image findings.…”

Section: Discussionmentioning

confidence: 99%

“…However, diagnostic accuracy of endoscopic ultrasound-guided FNA followed by cytomorphologic features and immunocytochemistry analysis is only 66.7% in schwannoma [25]. Out of nine patients with lipoblastoma, the FNA diagnosis was inconclusive due to hypocellularity in one patient, and a diagnosis of benign lipomatous tumor was made in another patient [26]. Regarding histiocytic sarcoma, the diagnosis with FNA alone is extremely challenging [27].…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

The diagnostic utility of retroperitoneoscopic tissue biopsy for unresectable retroperitoneal lesions excluding urogenital cancers

Miyake

Fukui²,

Gotoh

et al. 2019

World J Surg Onc

View full text Add to dashboard Cite

Background Retroperitoneal tumors are an uncommon disease known to consist of a diverse group of benign and malignant neoplasms. Treatment of unresectable retroperitoneal lesions requires pathological diagnosis. Here, we report the utility and safety of retroperitoneoscopic biopsy for unresectable retroperitoneal lesions excluding urogenital cancers. Methods We analyzed 47 patients consisting of 23 (49%) and 24 (51%) cases that underwent retroperitoneoscopic tissue biopsy and open biopsy, respectively. The clinicopathological features, including postoperative complications, were compared between the two groups. Results Tumor pathology was diagnosed successfully with a single operation in all patients. Malignant pathology (68%) was more common than benign pathology (32%). The most common pathology was malignant lymphoma, which accounted for about 50% of all cases. There was no significant difference with respect to the age, sex, tumor size, presence of tumor-related symptom, histopathology, operative time, and complications. Three (13%) of 23 patients in the retroperitoneoscopic biopsy group received percutaneous needle biopsy before laparoscopic excisional biopsy because the evaluation of needle cores failed to confirm subclasses of diagnosed pathologies. One patient was converted to open surgery just after the initiation of operation due to severe adhesion of adjacent structures. We had two cases with iatrogenic urinoma due to ureteral injury after retroperitoneoscopic biopsy. Conclusions We conclude that retroperitoneoscopic biopsy is a safe and useful tool for benign and malignant retroperitoneal lesions, in comparison to open biopsy. It is critical to carefully examine the preoperative imaging for the location of tumors, especially those close to the renal pelvis and ureter.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

The diagnostic utility of retroperitoneoscopic tissue biopsy for unresectable retroperitoneal lesions excluding urogenital cancers

Miyake

Fukui²,

Gotoh

et al. 2019

World J Surg Onc

View full text Add to dashboard Cite

show abstract

“…Both the tumours were of large size. Previous reports of FNA of lipoblastoma have also highlighted similar myxoid change and delicate capillary network as important morphological features . By contrast, the presence of uni‐/multi‐vacuolated lipoblasts can lead to an over‐diagnosis of myxoid liposarcoma …”

Section: Discussionmentioning

confidence: 94%

Fine needle aspiration cytology of paediatric soft tissue tumours highlighting challenges in diagnosis of benign lesions and unusual malignant tumours

et al. 2019

View full text Add to dashboard Cite

Introduction The type of soft tissue lesions seen in children differs from that seen in adults. The role of fine needle aspiration (FNA) cytology in their diagnosis is not well documented. Aim To study the cytopathological spectrum of paediatric soft tissue tumours to highlight uncommon benign and malignant lesions and the challenges in their diagnosis. Methods A 3‐year retrospective audit of all paediatric soft tissue FNA cytology cases from 2015 to 2017 was performed. Smears were reviewed along with cell block immunocytochemistry and follow‐up histopathology of resected specimens wherever available. Results A total of 127 cases were reviewed, which included 72 benign and 55 malignant soft tissue tumours. Uncommon lesions described herein are myxoid fibrohistiocytic tumour, myxoma, lipoblastoma, Bednar tumour, malignant extra‐renal rhabdoid tumour and desmoplastic small round cell tumour. Histopathology confirmation was available in 25 cases, out of which 16 cases were completely concordant. In eight cases, all benign diagnoses, histopathology provided more accurate subtyping than FNA. These included cases of lipoblastoma, myxoma and spindle cell haemangioma. Conclusion FNA cytology of paediatric soft tissue tumours is accurate in classifying lesions as benign or malignant which helps in treatment planning. Immunocytochemistry performed on cell blocks is useful for subtyping malignant lesions.

show abstract

“…Microscopic features consist of lobular architecture and myxoid areas with spindle cells and lipoblasts at various stages of differentiation [28,29].…”

Section: Discussionmentioning

confidence: 99%

“…Rearrangements of chromosome 8q11 codifying for the oncogene PLAG1 are found in more than 70% of cases [2][3][4][28][29][30]. The different molecular alteration found in adipocytic tumors could help in differentiating between lipoma, lipoblastoma, and liposarcoma [31].…”

Section: Discussionmentioning

confidence: 99%

A Rare Case of Giant Mesenteric Lipoblastoma in a 6-Year-Old Child and Review of the Literature

Miscia

Lisi

Lauriti

et al. 2020

Case Reports in Surgery

View full text Add to dashboard Cite

Giant mesenteric lipoblastoma is a rare benign tumor arising from the adipocytes. It can mimic malignant tumors, and its diagnosis is difficult before surgery. Imaging studies could lead the diagnosis but not confirm it. Those tumors arising in the abdomen are usually larger and can cause symptoms of compression. Surgical excision is the treatment of choice, and a long-term follow-up is necessary to detect local recurrences. Only a few cases of lipoblastomas arising from the mesentery are reported in literature. We present a case of a rare giant lipoblastoma arising from the mesentery of a 6-year-old girl, with a history of postprandial abdominal pain.

show abstract

Fine‐needle aspiration of lipoblastoma: Cytological, molecular, and clinical features

Abstract: FNA, especially if used together with molecular biology techniques (eg, PLAG1 FISH analysis), is a reliable and accurate diagnostic tool. Cancer Cytopathol 2017;125:934-9. © 2017 American Cancer Society.

Cited by 20 publications

References 32 publications

The diagnostic utility of retroperitoneoscopic tissue biopsy for unresectable retroperitoneal lesions excluding urogenital cancers

The diagnostic utility of retroperitoneoscopic tissue biopsy for unresectable retroperitoneal lesions excluding urogenital cancers

Fine needle aspiration cytology of paediatric soft tissue tumours highlighting challenges in diagnosis of benign lesions and unusual malignant tumours

A Rare Case of Giant Mesenteric Lipoblastoma in a 6-Year-Old Child and Review of the Literature

Contact Info

Product

Resources

About