Fine Needle Aspiration of Male Breast Lesions

Rosen, Daniel; Laucirica, Rodolfo; Verstovsek, Gordana

doi:10.1159/000325335

Cited by 22 publications

(11 citation statements)

References 18 publications

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“…Two studies that compared FNA with core and/or excision biopsies demonstrated that the former had sensitivity and specificity that approached 100%. 33,34 This is comparable with large studies in female disease in which sensitivity and specificity were reported as 97.1% and 99.1%, respectively. 35 Where FNA is equivocal or inadequate, a core biopsy is indicated.…”

Section: The Diagnostic Pathwaysupporting

confidence: 86%

New Approaches in the Management of Male Breast Cancer

Patten

Sharifi

Fazel

2013

Clinical Breast Cancer

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Section: The Diagnostic Pathwaysupporting

confidence: 86%

New Approaches in the Management of Male Breast Cancer

Patten

Sharifi

Fazel

2013

Clinical Breast Cancer

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“…The most common diagnoses for palpable male breast lesions are gynecomastia and ductal carcinoma. A study from 2 large hospitals in Texas, USA, spanning from 1990 to 2007 found that gynecomastia accounted for 181 out of 217 (83.4%) male breast FNA biopsies and ductal carcinoma composed 12 (5.5%) of the FNA samples [17]. In our current study, FNA biopsy revealed gynecomastia in 22 (30%) aspirates and ductal carcinoma in 16 (21.6%) samples.…”

Section: Discussionsupporting

confidence: 53%

Diagnostic Value of Fine-Needle Aspiration in Male Breast Lesions

et al. 2019

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Objective: Differentiation between gynecomastia, a common cause of male breast enlargement, and breast cancer is crucial for appropriate management. Fine-needle aspiration biopsy has been shown to be sensitive and specific in assessing female breast lesions, comparable to core needle biopsy. Few such studies have been conducted in men. We assessed its diagnostic value in a male patient cohort. Study Design: Men who underwent fine-needle aspiration (FNA) for palpable breast lesions at Massachusetts General Hospital from January 2007 to December 2016 were evaluated. Clinical data, radiographic findings, and cytologic diagnoses of 74 breast FNA from 71 men were reviewed. Breast aspirates were classified as nondiagnostic, benign, atypical, suspicious for malignancy, or malignant. Histology was obtained in 37 cases, and clinical and radiological data were used as follow-up in 37 patients. Results: Most FNA biopsies (73%) were performed by cytopathologists, and 93.2% of the breast FNA in men were adequate; 58% showed benign processes, mostly gynecomastia (n = 22), and 28.4% (n = 21) were malignant, most often ductal carcinoma. No false-positive cytologies were obtained, and there was 1 false-negative cytology. In our study, FNA of palpable male breast lesions was 95.8% sensitive and 100% specific. Conclusions: FNA allows sensitive, specific, and safe evaluation and diagnosis of palpable male breast lesions.

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“…In a more recent series of 217 patients evaluated for a breast mass with FNA, pathologic analysis suggested carcinoma in 12 cases (5.5%), suspicious findings in 5 cases (2.3%) and no malignancy in 181 cases (83.4%). 29 In 26 of these cases (12%), matching biopsies were available. Similar to the previous study, the sensitivity and specificity for detecting malignancy with FNA was 100%.…”

Section: Diagnosismentioning

confidence: 99%

Male breast cancer: An update in diagnosis, treatment and molecular profiling

et al. 2010

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Significant advances have been made in the diagnosis and treatment of female breast cancer, resulting in a decline in incidence and a global improvement in clinical outcome. The statistics for male breast cancer (MBC) stand in sharp contrast – over the past several decades, there has been a steady rise in the incidence of this disease, and clinical outcome has improved at a much slower pace. In the current review, the clinicopathologic features of MBC are described in detail. An emphasis is placed on molecular profiling of MBC, which may identify candidate biomarkers and putative targets for pharmacologic intervention. The current role of cytotoxic chemotherapy and endocrine therapy (including tamoxifen, aromatase inhibitors and GnRH analogues) is defined in the context of currently available studies. Furthermore, the potential role of targeted agents, including HER2-directed therapies, PARP inhibitors, and angiogenesis inhibitors, is delineated.

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Fine Needle Aspiration of Male Breast Lesions

Cited by 22 publications

References 18 publications

New Approaches in the Management of Male Breast Cancer

New Approaches in the Management of Male Breast Cancer

Diagnostic Value of Fine-Needle Aspiration in Male Breast Lesions

Male breast cancer: An update in diagnosis, treatment and molecular profiling

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