Fine-needle aspiration of metastatic nonlymphomatous tumors to the major salivary glands

Abstract

BACKGROUND Metastatic tumors to the salivary glands are common, but documentation in the cytologic literature has been limited. The current study presents the authors' experience with fine‐needle aspiration (FNA) in metastatic nonlymphomatous tumors to the salivary glands. METHODS From a retrospective review of 1675 salivary gland lesions (1535 patients), the authors collected 40 salivary gland lesions (39 patients who had histories of extrasalivary cancer) that were diagnosed cytologically as metastases to the salivary glands and were correlated histologically. RESULTS FNAs of 34 parotid gland and 6 submandibular gland tumors were performed. The cytologic diagnoses of metastases of squamous cell carcinoma (15 cases), melanoma (12 cases), carcinoma (5 cases), rhabdomyosarcoma (3 cases), and retinoblastoma (2 cases) were confirmed (95%) histologically. Two (5%) FNAs were false‐negative. CONCLUSIONS In patients who had a history of extrasalivary cancer, cytology examination was very helpful and sufficient for adequate patient management. Cancer (Cancer Cytopathol) 2000;90:350–356. © 2000 American Cancer Society.

Prevalence of Submandibular Gland Synucleinopathy in Parkinson’s Disease, Dementia with Lewy Bodies and other Lewy Body Disorders

“…We chose to pursue further studies in the submandibular gland as we thought it would be the least invasive site to biopsy. Needle biopsy has been extensively used to investigate submandibular gland neoplasms [65]. Other salivary glands, including the parotid gland, sublingual glands and minor (labial) salivary glands, might also be considered as potential biopsy sites.…”

Salivary Gland Tumor Fine-Needle Aspiration Cytology

“…While lymph nodes in the region of the parotid and submandibular gland are often the site of metastatic disease from both cutaneous and mucosal sites in the head and neck, cytomorphology (eg, keratinization would suggest a squamous cell lesion), clinical history, and ancillary testing with immunostains should be able to identify most metastatic lesions. 32,33 Future studies should include metastatic lesions to evaluate more clearly the ability to exclude these from categorization and to determine where particular metastatic tumors would most commonly be categorized if they are included. We would predict that metastatic lesions would mostly fall into the pleomorphic categories, especially the pleomorphic oncocytoid neoplasm category.…”

Diagnostic Accuracy of Fine Needle Aspiration Cytology in Parotid Lesions

“…Many authors considered FNAC a superior modality and claimed it accurate and safe [6, 11–13]. In contrast, others argued that it has little influence on clinical management because of its high rates of false-positives and false-negatives and also ultimately patients have to undergo surgery [15].…”

“…It is regarded as a diagnostic procedure to be superior to the combination of physical examination and radiological evaluation [9, 10]. Many authors claimed that it is accurate, safe and cost effective [11–13]. It can also be performed in children older than seven years [14].…”