Fine-needle aspiration of subacute granulomatous thyroiditis (De Quervain's thyroiditis): A clinico-cytologic review of 36 cases

Abstract

Although subacute granulomatous thyroiditis (SGT) is usually diagnosed clinically, there are other thyroid conditions that must be ruled out. This task is achieved by means of fine‐needle aspiration (FNA). In retrospect, the clinical and cytologic findings seen in 36 SGT cases are reassessed with a view to deciding which findings are most reliable for reaching a confident cytologic diagnosis. These are: the simultaneous presence in the same aspirate of the following cells: 1) follicular cells with intravacuolar granules and/or plump transformed follicular cells; 2) epithelioid granulomas; 3) multinucleated giant cells; 4) an acute and chronic inflammatory dirty background; 5) the absence of the following cells: fire‐flare cells, hypertrophic follicular cells, oncocytic cells, and transformed lymphocytes. The absence of one or more of these requirements does not exclude SGT but does increase the number of thyroid conditions that come into the differential diagnosis. In these cases, it is essential to review clinical data carefully and to submit the patient to a close clinical and FNA follow‐up. Diagn. Cytopathol. 16:214–220, 1997. © 1997 Wiley‐Liss, Inc.

Fine Needle Aspiration Cytology of Subacute Granulomatous Thyroiditis: A Clinico-Cytological Review of 10 Cases with Immunocytochemical Analysis

“…21 The aspirate of SGT usually dis- Our study was performed with Papanicolou stain and we were able to compare the reported cytologic features. 10,21 with those of our cases. Our cytologic results…”

“…The cytologic literature on SGT is relatively rare, but the cytologic features of SGT has been well described. 1,[4][5][6]10,21 One report summarized the key cytologic features of SGT with performing Giemsa staining. 10 and after that, another report has been published that used Papanicolou stain.…”

“…1,[4][5][6]10,21 One report summarized the key cytologic features of SGT with performing Giemsa staining. 10 and after that, another report has been published that used Papanicolou stain. 21 The aspirate of SGT usually dis- Our study was performed with Papanicolou stain and we were able to compare the reported cytologic features.…”

Thyroiditis: a Clinico-cytomorphological Study with a Reference to the Ethnic Groups of Northeast Regions of India

“…Cytomorphology of SAT shows mixed inflammatory cells with follicular cell degeneration and transformation, many epithelioid cells (with granulomas) and multinucleated cells [9] (Fig. 5).…”

Pharyngitis, Sturzsenkung und Hyperthyreose bei einer 71-j�hrigen Patientin

“…Eine Feinnadelpunktion der Schilddrü-se ergibt klassischerweise nicht-verkäse-nde Granulome mit mehrkernigen Riesenzellen vom Fremdkörpertyp, fibrotische Gewebestränge und eine Infiltration durch Immunzellen [14,17]. Die Wertigkeit einer zytopathologischen Diagnostik ist jedoch umstritten [18,19], da falschpositive Ergebnisse nicht selten [20] und gerade in der Akutphase der Erkrankung häufig die charakteristischen histologischen Merkmale nicht nachweisbar sind [21].…”